We are analyzing https://link.springer.com/article/10.1007/s12072-019-09994-9.

Title:
Circulating tumor cells are associated with poor outcomes in early-stage hepatocellular carcinoma: a prospective study | Hepatology International
Description:
Background Previous studies evaluating association between circulating tumor cells (CTCs) and clinical outcomes in hepatocellular carcinoma (HCC) have shown inconsistent results due to suboptimal detection methods and patient heterogeneity. Methods Patients undergoing surgery for early-stage HCC were prospectively enrolled. The CTC numbers were determined using a tapered slit platform, which detects CTCs based on the cell size and morphology. Survival and recurrence were evaluated, and Cox proportional hazards models were used to demonstrate the prognostic significance of CTC. Results Of 105 patients, 25 had increased CTC numbers after surgery (ΔCTC > 0, defined as positive) and a significantly higher level of recurrence (p = 0.042). A positive ΔCTC was seen to be an independent predictor of recurrence (hazard ratio 2.28), along with hepatitis B virus infection, alanine aminotransferase level, and the presence of satellite nodules (all p < 0.05). Subgroup analyses showed that a positive ΔCTC was associated with lower survival and higher recurrence among patients with low alpha-fetoprotein levels and cirrhosis (all p < 0.05). Conclusion Calculation of ΔCTC based on the physical properties of the cells is predictive of recurrence in patients with early HCC undergoing surgery.
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Topics {✒️}

month download article/chapter young-ho cho small-cell lung cancer small-cell lung cancer early-stage hepatocellular carcinoma han chu lee low alpha-fetoprotein levels tapered-slit membrane filters node-negative breast cancer circulating tumor cell cell search analysis pubmed central pmcid circulating stem cell circulating tumor cells hepatocellular carcinoma based circulating tumor microemboli circulating epithelial cells ewha womans university full article pdf privacy choices/manage cookies microfluidic cell sorting surgical liver resection tae hun kim mi jung jun early-stage hcc korea advanced institute article ha rare cell isolation /applications/cancer-cells related subjects alpha-fetoprotein mrna cell separation technologies hepatocellular carcinoma patients tapered slit filter jae eul shim asan medical center suboptimal detection methods tapered slit platform increased ctc numbers electronic supplementary material scirrhous feature detects ctcs based alanine aminotransferase level malignant breast lesions bmc cancer 2018 /pdf/e631600001/e631600001_en cell size check access instant access european economic area

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Circulating tumor cells in solid cancer: tumor marker of clinical relevance?

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         description:Previous studies evaluating association between circulating tumor cells (CTCs) and clinical outcomes in hepatocellular carcinoma (HCC) have shown inconsistent results due to suboptimal detection methods and patient heterogeneity. Patients undergoing surgery for early-stage HCC were prospectively enrolled. The CTC numbers were determined using a tapered slit platform, which detects CTCs based on the cell size and morphology. Survival and recurrence were evaluated, and Cox proportional hazards models were used to demonstrate the prognostic significance of CTC. Of 105 patients, 25 had increased CTC numbers after surgery (ΔCTC > 0, defined as positive) and a significantly higher level of recurrence (p = 0.042). A positive ΔCTC was seen to be an independent predictor of recurrence (hazard ratio 2.28), along with hepatitis B virus infection, alanine aminotransferase level, and the presence of satellite nodules (all p < 0.05). Subgroup analyses showed that a positive ΔCTC was associated with lower survival and higher recurrence among patients with low alpha-fetoprotein levels and cirrhosis (all p < 0.05). Calculation of ΔCTC based on the physical properties of the cells is predictive of recurrence in patients with early HCC undergoing surgery.
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            Nanomedicine
            Hepatocellular carcinoma
            Recurrence
            Survival
            Hepatology
            Colorectal Surgery
            Surgery
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         Hepatocellular carcinoma
         Recurrence
         Survival
         Hepatology
         Colorectal Surgery
         Surgery
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