We are analyzing https://link.springer.com/article/10.1007/s12038-020-00069-8.

Title:
Computational search for potential COVID-19 drugs from FDA-approved drugs and small molecules of natural origin identifies several anti-virals and plant products | Journal of Biosciences
Description:
The world is currently facing the COVID-19 pandemic, for which mild symptoms include fever and dry cough. In severe cases, it could lead to pneumonia and ultimately death in some instances. Moreover, the causative pathogen is highly contagious and there are no drugs or vaccines for it yet. The pathogen, SARS-CoV-2, is one of the human coronaviruses which was identified to infect humans first in December 2019. SARS-CoV-2 shares evolutionary relationship to other highly pathogenic viruses such as Severe Acute Respiratory Syndrome (SARS) and Middle East respiratory syndrome (MERS). We have exploited this similarity to model a target non-structural protein, NSP1, since it is implicated in the regulation of host gene expression by the virus and hijacking of host machinery. We next interrogated the capacity to repurpose around 2300 FDA-approved drugs and more than 3,00,000 small molecules of natural origin towards drug identification through virtual screening and molecular dynamics. Interestingly, we observed simple molecules like lactose, previously known anti-virals and few secondary metabolites of plants as promising hits. These herbal plants are already practiced in Ayurveda over centuries to treat respiratory problems and inflammation. Disclaimer: we would not like to recommend uptake of these small molecules for suspect COVID patients until it is approved by competent national or international authorities.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Science
Health & Fitness
Education

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We can't tell how the site generates income.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

nsp, article, protein, google, scholar, pubmed, simulation, figure, site, compounds, residues, docking, drugs, cas, covid, sarscov, host, binding, interactions, supplementary, natural, deep, screening, coronavirus, ligand, fdaapproved, shown, viral, acid, drug, interaction, shallow, virtual, sequence, database, time, glycyrrhizic, analysis, antiviral, complex, central, potential, virus, narayanan, esculin, sars, model, molecular, stable, molecules,

Topics {✒️}

vikas tiwari & ramanathan sowdhamini articles/news-articles/2020/3/covid-19-vaccine-tracker high-fat diet-fed mice nsp1-induced rna cleavage /articles/8-experimental-coronavirus-treatments insulin-dependent diabetes mellitus sars-coronavirus-host interactome pathogenic human-cov strain degrading ifn-beta mrna broad-spectrum neutralization activity receptor-grid generation module supplementary figures s1–s35 nose-hoover chain method fda-approved drugs binding fda-approved drug library herbal plants provide host gene expression anti-inflammatory anti-allergic high-throughput virtual screening fda-approved drugs docked suggesting strong drug-likeliness enables host-pathogen interaction viral gene expression protein-ligand interactions measured deoxy-thymidine analog shown prosa profile martyna-tobias-klein method human respiratory disease related subjects rational design fda-approved ligands docked herbal plants upper respiratory tract rna polymerase inhibitor privacy choices/manage cookies nsp1-shallow-glycyrrhizic acid pan-coronavirus inhibitors severe respiratory potent anti-inflammatory treatment glycyrrhizic acid-nsp1 interactions accurate binding-site identification predicted natural products protecting viral rna adme related properties host mrna degradation treat respiratory problems 2018 broad-spectrum neutralization potential drug-repurposing stable protein-ligand interactions open reading frames

Questions {❓}

2020 Colchicine as a potent anti-inflammatory treatment in COVID-19: can we teach an old dog new tricks?
Natural Products as Potential Leads Against Coronaviruses: Could They be Encouraging Structural Models Against SARS-CoV-2?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Computational search for potential COVID-19 drugs from FDA-approved drugs and small molecules of natural origin identifies several anti-virals and plant products
         description:The world is currently facing the COVID-19 pandemic, for which mild symptoms include fever and dry cough. In severe cases, it could lead to pneumonia and ultimately death in some instances. Moreover, the causative pathogen is highly contagious and there are no drugs or vaccines for it yet. The pathogen, SARS-CoV-2, is one of the human coronaviruses which was identified to infect humans first in December 2019. SARS-CoV-2 shares evolutionary relationship to other highly pathogenic viruses such as Severe Acute Respiratory Syndrome (SARS) and Middle East respiratory syndrome (MERS). We have exploited this similarity to model a target non-structural protein, NSP1, since it is implicated in the regulation of host gene expression by the virus and hijacking of host machinery. We next interrogated the capacity to repurpose around 2300 FDA-approved drugs and more than 3,00,000 small molecules of natural origin towards drug identification through virtual screening and molecular dynamics. Interestingly, we observed simple molecules like lactose, previously known anti-virals and few secondary metabolites of plants as promising hits. These herbal plants are already practiced in Ayurveda over centuries to treat respiratory problems and inflammation. Disclaimer: we would not like to recommend uptake of these small molecules for suspect COVID patients until it is approved by competent national or international authorities.
         datePublished:2020-07-17T00:00:00Z
         dateModified:2020-07-17T00:00:00Z
         pageStart:1
         pageEnd:18
         sameAs:https://doi.org/10.1007/s12038-020-00069-8
         keywords:
            Anti-virals
            drug design
            herbal plants
            repurposing drugs
            SARS-CoV-2
            Life Sciences
            general
            Biomedicine
            Zoology
            Plant Sciences
            Microbiology
            Cell Biology
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12038-020-00069-8/MediaObjects/12038_2020_69_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12038-020-00069-8/MediaObjects/12038_2020_69_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12038-020-00069-8/MediaObjects/12038_2020_69_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12038-020-00069-8/MediaObjects/12038_2020_69_Fig4_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12038-020-00069-8/MediaObjects/12038_2020_69_Fig5_HTML.png
         isPartOf:
            name:Journal of Biosciences
            issn:
               0973-7138
               0250-5991
            volumeNumber:45
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer India
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Abhishek Sharma
               affiliation:
                     name:National Centre for Biological Sciences
                     address:
                        name:National Centre for Biological Sciences, Bengaluru, India
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Vikas Tiwari
               affiliation:
                     name:National Centre for Biological Sciences
                     address:
                        name:National Centre for Biological Sciences, Bengaluru, India
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Ramanathan Sowdhamini
               affiliation:
                     name:National Centre for Biological Sciences
                     address:
                        name:National Centre for Biological Sciences, Bengaluru, India
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Computational search for potential COVID-19 drugs from FDA-approved drugs and small molecules of natural origin identifies several anti-virals and plant products
      description:The world is currently facing the COVID-19 pandemic, for which mild symptoms include fever and dry cough. In severe cases, it could lead to pneumonia and ultimately death in some instances. Moreover, the causative pathogen is highly contagious and there are no drugs or vaccines for it yet. The pathogen, SARS-CoV-2, is one of the human coronaviruses which was identified to infect humans first in December 2019. SARS-CoV-2 shares evolutionary relationship to other highly pathogenic viruses such as Severe Acute Respiratory Syndrome (SARS) and Middle East respiratory syndrome (MERS). We have exploited this similarity to model a target non-structural protein, NSP1, since it is implicated in the regulation of host gene expression by the virus and hijacking of host machinery. We next interrogated the capacity to repurpose around 2300 FDA-approved drugs and more than 3,00,000 small molecules of natural origin towards drug identification through virtual screening and molecular dynamics. Interestingly, we observed simple molecules like lactose, previously known anti-virals and few secondary metabolites of plants as promising hits. These herbal plants are already practiced in Ayurveda over centuries to treat respiratory problems and inflammation. Disclaimer: we would not like to recommend uptake of these small molecules for suspect COVID patients until it is approved by competent national or international authorities.
      datePublished:2020-07-17T00:00:00Z
      dateModified:2020-07-17T00:00:00Z
      pageStart:1
      pageEnd:18
      sameAs:https://doi.org/10.1007/s12038-020-00069-8
      keywords:
         Anti-virals
         drug design
         herbal plants
         repurposing drugs
         SARS-CoV-2
         Life Sciences
         general
         Biomedicine
         Zoology
         Plant Sciences
         Microbiology
         Cell Biology
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12038-020-00069-8/MediaObjects/12038_2020_69_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12038-020-00069-8/MediaObjects/12038_2020_69_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12038-020-00069-8/MediaObjects/12038_2020_69_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12038-020-00069-8/MediaObjects/12038_2020_69_Fig4_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12038-020-00069-8/MediaObjects/12038_2020_69_Fig5_HTML.png
      isPartOf:
         name:Journal of Biosciences
         issn:
            0973-7138
            0250-5991
         volumeNumber:45
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer India
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Abhishek Sharma
            affiliation:
                  name:National Centre for Biological Sciences
                  address:
                     name:National Centre for Biological Sciences, Bengaluru, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Vikas Tiwari
            affiliation:
                  name:National Centre for Biological Sciences
                  address:
                     name:National Centre for Biological Sciences, Bengaluru, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ramanathan Sowdhamini
            affiliation:
                  name:National Centre for Biological Sciences
                  address:
                     name:National Centre for Biological Sciences, Bengaluru, India
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Journal of Biosciences
      issn:
         0973-7138
         0250-5991
      volumeNumber:45
Organization:
      name:Springer India
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:National Centre for Biological Sciences
      address:
         name:National Centre for Biological Sciences, Bengaluru, India
         type:PostalAddress
      name:National Centre for Biological Sciences
      address:
         name:National Centre for Biological Sciences, Bengaluru, India
         type:PostalAddress
      name:National Centre for Biological Sciences
      address:
         name:National Centre for Biological Sciences, Bengaluru, India
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Abhishek Sharma
      affiliation:
            name:National Centre for Biological Sciences
            address:
               name:National Centre for Biological Sciences, Bengaluru, India
               type:PostalAddress
            type:Organization
      name:Vikas Tiwari
      affiliation:
            name:National Centre for Biological Sciences
            address:
               name:National Centre for Biological Sciences, Bengaluru, India
               type:PostalAddress
            type:Organization
      name:Ramanathan Sowdhamini
      affiliation:
            name:National Centre for Biological Sciences
            address:
               name:National Centre for Biological Sciences, Bengaluru, India
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:National Centre for Biological Sciences, Bengaluru, India
      name:National Centre for Biological Sciences, Bengaluru, India
      name:National Centre for Biological Sciences, Bengaluru, India

External Links {🔗}(183)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.83s.

LINK . SPRINGER . COM {}