We are analyzing https://link.springer.com/article/10.1007/s12038-017-9691-8.

Title:
Differential reduction of reactive oxygen species by human tissue-specific mesenchymal stem cells from different donors under oxidative stress | Journal of Biosciences
Description:
Clinical trials using human Mesenchymal Stem Cells (MSCs) have shown promising results in the treatment of various diseases. Different tissue sources, such as bone marrow, adipose tissue, dental pulp and umbilical cord, are being routinely used in regenerative medicine. MSCs are known to reduce increased oxidative stress levels in pathophysiological conditions. Differences in the ability of MSCs from different donors and tissues to ameliorate oxidative damage have not been reported yet. In this study, for the first time, we investigated the differences in the reactive oxygen species (ROS) reduction abilities of tissue-specific MSCs to mitigate cellular damage in oxidative stress. Hepatic Stellate cells (LX-2) and cardiomyocytes were treated with Antimycin A (AMA) to induce oxidative stress and tissue specific MSCs were co-cultured to study the reduction in ROS levels. We found that both donor’s age and source of tissue affected the ability of MSCs to reduce increased ROS levels in damaged cells. In addition, the abilities of same MSCs differed in LX-2 and cardiomyocytes in terms of magnitude of reduction of ROS, suggesting that the type of recipient cells should be kept in consideration when using MSCs in regenerative medicine for treatment purposes.
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Topics {✒️}

bone-marrow-derived stromal cells month download article/chapter oxidative stress-induced toxicity reactive oxygen species mesenchymal stem cells mesenchymal stromal cells stem cells dev tissue-specific mscs tissue specific mscs article paliwal stem cell res stem cells int hepatic stellate cells acute lung injury cancer cell metabolism full article pdf induce oxidative stress umbilical cord blood author information authors privacy choices/manage cookies endothelial progenitor cells acute tubular injury ros-induced apoptosis regenerative medicine applied electronic supplementary material ameliorate oxidative damage support hematopoietic reconstitution cell therapy check access pulmonary alveoli protects instant access sujata mohanty 2014 differential efficacy article journal european economic area shown promising results mitigate cellular damage author correspondence oxidative stress 2003 oxidative stress umbilical cord xeno-free conditions 2012 mitochondrial transfer conditions privacy policy article log adipose tissue accepting optional cookies liver fibrosis bone marrow bone marrow

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         description:Clinical trials using human Mesenchymal Stem Cells (MSCs) have shown promising results in the treatment of various diseases. Different tissue sources, such as bone marrow, adipose tissue, dental pulp and umbilical cord, are being routinely used in regenerative medicine. MSCs are known to reduce increased oxidative stress levels in pathophysiological conditions. Differences in the ability of MSCs from different donors and tissues to ameliorate oxidative damage have not been reported yet. In this study, for the first time, we investigated the differences in the reactive oxygen species (ROS) reduction abilities of tissue-specific MSCs to mitigate cellular damage in oxidative stress. Hepatic Stellate cells (LX-2) and cardiomyocytes were treated with Antimycin A (AMA) to induce oxidative stress and tissue specific MSCs were co-cultured to study the reduction in ROS levels. We found that both donor’s age and source of tissue affected the ability of MSCs to reduce increased ROS levels in damaged cells. In addition, the abilities of same MSCs differed in LX-2 and cardiomyocytes in terms of magnitude of reduction of ROS, suggesting that the type of recipient cells should be kept in consideration when using MSCs in regenerative medicine for treatment purposes.
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         Plant Sciences
         Microbiology
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