We are analyzing https://link.springer.com/article/10.1007/s12038-015-9518-4.

Title:
Anti-tumour immune effect of oral administration of Lactobacillus plantarum to CT26 tumour-bearing mice | Journal of Biosciences
Description:
Colorectal cancer (CRC) is one of the most prevalent forms of cancer that shows a high mortality and increasing incidence. There are numerous successful treatment options for CRC, including surgery, chemotherapy, radiotherapy and immunotherapy; however, their side effects and limitations are considerable. Probiotics may be an effective strategy for preventing and inhibiting tumour growth through stimulation of host innate and adaptive immunity. We investigated and compared potential anti-tumour immune responses induced by two isolated Lactobacillus strains, Lactobacillus plantarum A and Lactobacillus rhamnosus b, by pre-inoculating mice with lactobacilli for 14 days. Subsequently, subcutaneous and orthotopic intestinal tumours were generated in the pre-inoculated mice using CT26 murine adenocarcinoma cells and were assessed for response against the tumour. Our results indicated that oral administration with L. plantarum inhibited CT26 cell growth in BALB/c mice and prolonged the survival time of tumour-bearing mice compared with mice administered L. rhamnosus. L. plantarum produced protective immunity against the challenge with CT26 cells by increasing the effector functions of CD8+ and natural killer (NK) cell infiltration into tumour tissue, up-regulation of IFN-γ (but not IL-4 or IL-17) production, and promotion of Th1-type CD4+ T differentiation. Consequently, our results suggest that L. plantarum can enhance the anti-tumour immune response and delay tumour formation.
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Keywords {🔍}

article, google, scholar, pubmed, cancer, cas, lactobacillus, cells, plantarum, mice, colorectal, immune, cell, probiotic, wang, tumour, dendritic, probiotics, immunity, strains, colon, sci, research, effect, shi, lactobacilli, natural, antitumor, central, vivo, clin, tumor, privacy, cookies, content, journal, antitumour, oral, yang, huang, effects, growth, isolated, intestinal, murine, response, killer, access, model, products,

Topics {✒️}

month download article/chapter tumour-bearing mice compared ct26 tumour-bearing mice den bak-glashouwer mj innate anti-tumor immunity anti-tumour immune effect counter-regulates th2 responses anti-tumour immune response lactobacillus plantarum egd-aq4 tumour cell growth murine dendritic cells full article pdf anti-tumor polysaccharide inhibiting tumour growth efficient immune responses 1007/s12038-015-9518-4 rights ht-29 cells apoptosis colon cancer prevention delay tumour formation privacy choices/manage cookies related subjects agro-scientific research lactobacillus acidophilus combined isolated lactobacillus strains mouse breast cancer article hu orthotopic intestinal tumours chinese special fund lactic acid bacteria probiotic bacteria occurs pre-inoculating mice pre-inoculated mice breast cancer cells zhuang ding conjugated linoleic acid 2000 strain-dependent induction microencapsulated lactobacillus casei natural killer european economic area ct26 cells th1-type cd4+ malaria parasite infection maturation surface markers van holten-neelen t-helper 1 polarization oncolytic virotherapy immunother article journal conditions privacy policy higher education press dendritic cells

Questions {❓}

Azcárate-Peril MA, Sikes M and Bruno-Bárcena JM 2011 The intestinal microbiota, gastrointestinal environment and colorectal cancer: a putative role for probiotics in prevention of colorectal cancer?
Geier MS, Butler RN and Howarth GS 2006 Probiotics, Prebiotics and Synbiotics: A Role in Chemoprevention for Colorectal Cancer?

Schema {🗺️}

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         description:Colorectal cancer (CRC) is one of the most prevalent forms of cancer that shows a high mortality and increasing incidence. There are numerous successful treatment options for CRC, including surgery, chemotherapy, radiotherapy and immunotherapy; however, their side effects and limitations are considerable. Probiotics may be an effective strategy for preventing and inhibiting tumour growth through stimulation of host innate and adaptive immunity. We investigated and compared potential anti-tumour immune responses induced by two isolated Lactobacillus strains, Lactobacillus plantarum A and Lactobacillus rhamnosus b, by pre-inoculating mice with lactobacilli for 14 days. Subsequently, subcutaneous and orthotopic intestinal tumours were generated in the pre-inoculated mice using CT26 murine adenocarcinoma cells and were assessed for response against the tumour. Our results indicated that oral administration with L. plantarum inhibited CT26 cell growth in BALB/c mice and prolonged the survival time of tumour-bearing mice compared with mice administered L. rhamnosus. L. plantarum produced protective immunity against the challenge with CT26 cells by increasing the effector functions of CD8+ and natural killer (NK) cell infiltration into tumour tissue, up-regulation of IFN-γ (but not IL-4 or IL-17) production, and promotion of Th1-type CD4+ T differentiation. Consequently, our results suggest that L. plantarum can enhance the anti-tumour immune response and delay tumour formation.
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      headline:Anti-tumour immune effect of oral administration of Lactobacillus plantarum to CT26 tumour-bearing mice
      description:Colorectal cancer (CRC) is one of the most prevalent forms of cancer that shows a high mortality and increasing incidence. There are numerous successful treatment options for CRC, including surgery, chemotherapy, radiotherapy and immunotherapy; however, their side effects and limitations are considerable. Probiotics may be an effective strategy for preventing and inhibiting tumour growth through stimulation of host innate and adaptive immunity. We investigated and compared potential anti-tumour immune responses induced by two isolated Lactobacillus strains, Lactobacillus plantarum A and Lactobacillus rhamnosus b, by pre-inoculating mice with lactobacilli for 14 days. Subsequently, subcutaneous and orthotopic intestinal tumours were generated in the pre-inoculated mice using CT26 murine adenocarcinoma cells and were assessed for response against the tumour. Our results indicated that oral administration with L. plantarum inhibited CT26 cell growth in BALB/c mice and prolonged the survival time of tumour-bearing mice compared with mice administered L. rhamnosus. L. plantarum produced protective immunity against the challenge with CT26 cells by increasing the effector functions of CD8+ and natural killer (NK) cell infiltration into tumour tissue, up-regulation of IFN-γ (but not IL-4 or IL-17) production, and promotion of Th1-type CD4+ T differentiation. Consequently, our results suggest that L. plantarum can enhance the anti-tumour immune response and delay tumour formation.
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         general
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         Cell Biology
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