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LINK . SPRINGER . COM {}

  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Questions
  9. Schema
  10. External Links
  11. Analytics And Tracking
  12. Libraries
  13. CDN Services

We are analyzing https://link.springer.com/article/10.1007/s12035-022-02800-y.

Title:
Inflammation and Nitro-oxidative Stress as Drivers of Endocannabinoid System Aberrations in Mood Disorders and Schizophrenia | Molecular Neurobiology
Description:
The endocannabinoid system (ECS) is composed of the endocannabinoid ligands anandamide (AEA) and 2-arachidonoylgycerol (2-AG), their target cannabinoid receptors (CB1 and CB2) and the enzymes involved in their synthesis and metabolism (N-acyltransferase and fatty acid amide hydrolase (FAAH) in the case of AEA and diacylglycerol lipase (DAGL) and monoacylglycerol lipase (MAGL) in the case of 2-AG). The origins of ECS dysfunction in major neuropsychiatric disorders remain to be determined, and this paper explores the possibility that they may be associated with chronically increased nitro-oxidative stress and activated immune-inflammatory pathways, and it examines the mechanisms which might be involved. Inflammation and nitro-oxidative stress are associated with both increased CB1 expression, via increased activity of the NADPH oxidases NOX4 and NOX1, and increased CNR1 expression and DNA methylation; and CB2 upregulation via increased pro-inflammatory cytokine levels, binding of the transcription factor Nrf2 to an antioxidant response element in the CNR2 promoter region and the action of miR-139. CB1 and CB2 have antagonistic effects on redox signalling, which may result from a miRNA-enabled negative feedback loop. The effects of inflammation and oxidative stress are detailed in respect of AEA and 2-AG levels, via effects on calcium homeostasis and phospholipase A2 activity; on FAAH activity, via nitrosylation/nitration of functional cysteine and/or tyrosine residues; and on 2-AG activity via effects on MGLL expression and MAGL. Finally, based on these detailed molecular neurobiological mechanisms, it is suggested that cannabidiol and dimethyl fumarate may have therapeutic potential for major depressive disorder, bipolar disorder and schizophrenia.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Education
  • Health & Fitness
  • Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

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How Does Link.springer.com Make Money? {💸}

We can't see how the site brings in money.

Not every website is profit-driven; some are created to spread information or serve as an online presence. Websites can be made for many reasons. This could be one of them. Link.springer.com could be getting rich in stealth mode, or the way it's monetizing isn't detectable.

Keywords {🔍}

pubmed, article, google, scholar, cas, central, receptor, cannabinoid, endocannabinoid, mol, biol, psychiatry, pharmacol, neurosci, stress, calcium, cells, schizophrenia, cell, system, signaling, oxidative, expression, disorder, httpsdoiorgs, patients, sci, res, disorders, httpsdoiorg, receptors, bipolar, depression, cannabidiol, role, human, phospholipase, front, research, inflammation, brain, activation, med, disease, multiple, sclerosis, cannabinoids, lipase, major, effects,

Topics {✒️}

cd14/mapk/phosphoinositide 3-kinase/nf-κb independently anoxia-induced nf-kappab-dependent upregulation interferon-β/stat proinflammatory pathways month download article/chapter central cb1-receptor availability hydrogen peroxide-induced apoptosis lps-activated bv-2 microglia—effect store-operated calcium entry lipopolysaccharide-activated nf-κb store-operated calcium channels l-type calcium channels neurotoxin-induced er stress 6-hydroxydopamine-induced cell death microrna-139 modulates alzheimer’s hplc–electrospray-tandem ms received grant/research support oxidation-sensitive cysteine residues delayed-release dimethyl fumarate oxidative stress-induced damage tgf-β1/smad3 pathway ca2+-dependent n-acyltransferase redox-sensitive cation channel cell-mediated immune activation stress-induced behavioral adaptation cisplatin-induced hearing loss pet radioligand [11c]omar activated immune-inflammatory pathways pi3k/akt/mtor pathway dissecting molecular cross-talk hepatic ischemia/reperfusion injury gomes fv nf-κb response pathways gsk-3β/nrf2 axis decreasing oxidative/nitrosative stress decreased mir-128-3p alleviates isothiazolinone-based enzyme inhibitors rodrigues da silva cannabis sativa revisited—crosstalk expanded endocannabinoid system/endocannabinoidome oxidative/nitrosative signaling pathways activating microrna-139/nrf2 axis sim-selley lj produces n-acyl phosphatidylethanolamines store-operated icrac relapsing–remitting multiple sclerosis central nervous system anti-inflammatory drugs garcía-gutiérrez ms full article pdf mirna expression profiles

Questions {❓}

  • Berk M, Williams LJ, Jacka FN et al (2013) So depression is an inflammatory disease, but where does the inflammation come from?
  • Cortez IL, Rodrigues da Silva N, Guimarães FS, Gomes FV (2020) Are CB2 receptors a new target for schizophrenia treatment?
  • Grützner TM, Listunova L, Fabian GA et al (2018) Serum calcium levels and neuropsychological performance in depression and matched healthy controls: reversal of correlation a marker of the aging cognitive clock?
  • Kourakis S, Timpani CA, de Haan JB et al (2020) Dimethyl fumarate and its esters: a drug with broad clinical utility?
  • Lipina C, Hundal HS (2017) The endocannabinoid system: ‘NO’ longer anonymous in the control of nitrergic signalling?
  • Morris G, Maes M, Murdjeva M, Puri BK (2019) Do human endogenous retroviruses contribute to multiple sclerosis, and if so, how?
  • Morris G, Walder KR, Berk M et al (2020) The interplay between oxidative stress and bioenergetic failure in neuropsychiatric illnesses: can we explain it and can we treat it?
  • Schennach R, Zill P, Obermeier M et al (2012) The CNR1 gene in depression and schizophrenia — Is there an association with early improvement and response?

Schema {🗺️}

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         headline:Inflammation and Nitro-oxidative Stress as Drivers of Endocannabinoid System Aberrations in Mood Disorders and Schizophrenia
         description:The endocannabinoid system (ECS) is composed of the endocannabinoid ligands anandamide (AEA) and 2-arachidonoylgycerol (2-AG), their target cannabinoid receptors (CB1 and CB2) and the enzymes involved in their synthesis and metabolism (N-acyltransferase and fatty acid amide hydrolase (FAAH) in the case of AEA and diacylglycerol lipase (DAGL) and monoacylglycerol lipase (MAGL) in the case of 2-AG). The origins of ECS dysfunction in major neuropsychiatric disorders remain to be determined, and this paper explores the possibility that they may be associated with chronically increased nitro-oxidative stress and activated immune-inflammatory pathways, and it examines the mechanisms which might be involved. Inflammation and nitro-oxidative stress are associated with both increased CB1 expression, via increased activity of the NADPH oxidases NOX4 and NOX1, and increased CNR1 expression and DNA methylation; and CB2 upregulation via increased pro-inflammatory cytokine levels, binding of the transcription factor Nrf2 to an antioxidant response element in the CNR2 promoter region and the action of miR-139. CB1 and CB2 have antagonistic effects on redox signalling, which may result from a miRNA-enabled negative feedback loop. The effects of inflammation and oxidative stress are detailed in respect of AEA and 2-AG levels, via effects on calcium homeostasis and phospholipase A2 activity; on FAAH activity, via nitrosylation/nitration of functional cysteine and/or tyrosine residues; and on 2-AG activity via effects on MGLL expression and MAGL. Finally, based on these detailed molecular neurobiological mechanisms, it is suggested that cannabidiol and dimethyl fumarate may have therapeutic potential for major depressive disorder, bipolar disorder and schizophrenia.
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      headline:Inflammation and Nitro-oxidative Stress as Drivers of Endocannabinoid System Aberrations in Mood Disorders and Schizophrenia
      description:The endocannabinoid system (ECS) is composed of the endocannabinoid ligands anandamide (AEA) and 2-arachidonoylgycerol (2-AG), their target cannabinoid receptors (CB1 and CB2) and the enzymes involved in their synthesis and metabolism (N-acyltransferase and fatty acid amide hydrolase (FAAH) in the case of AEA and diacylglycerol lipase (DAGL) and monoacylglycerol lipase (MAGL) in the case of 2-AG). The origins of ECS dysfunction in major neuropsychiatric disorders remain to be determined, and this paper explores the possibility that they may be associated with chronically increased nitro-oxidative stress and activated immune-inflammatory pathways, and it examines the mechanisms which might be involved. Inflammation and nitro-oxidative stress are associated with both increased CB1 expression, via increased activity of the NADPH oxidases NOX4 and NOX1, and increased CNR1 expression and DNA methylation; and CB2 upregulation via increased pro-inflammatory cytokine levels, binding of the transcription factor Nrf2 to an antioxidant response element in the CNR2 promoter region and the action of miR-139. CB1 and CB2 have antagonistic effects on redox signalling, which may result from a miRNA-enabled negative feedback loop. The effects of inflammation and oxidative stress are detailed in respect of AEA and 2-AG levels, via effects on calcium homeostasis and phospholipase A2 activity; on FAAH activity, via nitrosylation/nitration of functional cysteine and/or tyrosine residues; and on 2-AG activity via effects on MGLL expression and MAGL. Finally, based on these detailed molecular neurobiological mechanisms, it is suggested that cannabidiol and dimethyl fumarate may have therapeutic potential for major depressive disorder, bipolar disorder and schizophrenia.
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      dateModified:2022-03-26T00:00:00Z
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         Endocannabinoid system
         Cannabidiol
         Dimethyl fumarate
         Major depressive disorder
         Bipolar disorder
         Schizophrenia
         Neurosciences
         Neurobiology
         Cell Biology
         Neurology
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      name:Michael Maes
      affiliation:
            name:Deakin University
            address:
               name:IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, Australia
               type:PostalAddress
            type:Organization
            name:King Chulalongkorn Memorial Hospital
            address:
               name:Department of Psychiatry, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand
               type:PostalAddress
            type:Organization
            name:Medical University of Plovdiv
            address:
               name:Department of Psychiatry, Medical University of Plovdiv, Plovdiv, Bulgaria
               type:PostalAddress
            type:Organization
      name:Basant K. Puri
      url:http://orcid.org/0000-0001-6101-0139
      affiliation:
            name:University of Winchester and C.A.R
            address:
               name:University of Winchester and C.A.R, Cambridge, UK
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, Australia
      name:IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, Australia
      name:IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, Australia
      name:IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, Australia
      name:Orygen, The National Centre of Excellence in Youth Mental Health, Centre for Youth Mental Health, Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry, The University of Melbourne, Melbourne, Australia
      name:IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, Australia
      name:Campbell Family Mental Health Research Institute, CAMH, Toronto, Canada
      name:Department of Psychiatry, University of Toronto, Toronto, Canada
      name:Deakin University, Victoria, Australia
      name:IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, Australia
      name:IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, Australia
      name:Department of Psychiatry, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand
      name:Department of Psychiatry, Medical University of Plovdiv, Plovdiv, Bulgaria
      name:University of Winchester and C.A.R, Cambridge, UK
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