We are analyzing https://link.springer.com/article/10.1007/s12033-024-01267-7.

Title:
Nonsense-Mediated mRNA Decay in Human Health and Diseases: Current Understanding, Regulatory Mechanisms and Future Perspectives | Molecular Biotechnology
Description:
Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that is conserved across all eukaryotes ensuring the quality of transcripts by targeting messenger RNA (mRNA) harbouring premature stop codons. It regulates the gene expression by targeting aberrant mRNA carrying pre-termination codons (PTCs) and eliminates C-terminal truncated proteins. NMD distinguishes aberrant and non-aberrant transcript by looking after long 3′ UTRs and exon-junction complex (EJC) downstream of stop codon that indicate the presence of PTC. Therefore, NMD modulates cellular surveillance and eliminates the truncated proteins but if the PTC escapes the surveillance pathway it can lead to potential negative phenotype resulting in genetic diseases. The alternative splicing also contributes in formation of NMD-sensitive isoforms by introducing PTC. NMD plays a complex role in cancer, it can either aggravate or downregulates the tumour. Some tumours agitate NMD to deteriorate mRNAs encoding tumour suppressor proteins, stress response proteins and neoantigens. In other case, tumours suppress the NMD to encourage the expression of oncoproteins for tumour growth and survival. This mechanism augmented in the development of new therapeutics by PTC read-through mechanism and personalized medicine. Detailed studies on NMD surveillance will possibly lead towards development of strategies for improving human health aligning with United Nations sustainable development goals (SDG 3: Good health and well-being). The potential therapeutic applications of NMD pose a challenge in terms of safe and effective modulation. Understanding the complexities of NMD regulation and its interaction with other cellular processes can lead to the development of new interventions for various diseases.
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Keywords {🔍}

pubmed, article, google, scholar, cas, decay, nonsensemediated, mrna, central, cancer, rna, molecular, human, cell, journal, research, nature, upf, complex, nmd, surveillance, panigrahi, splicing, sahoo, plant, smg, pathway, maquat, genetics, gene, development, biology, genes, nucleic, satapathy, exon, alternative, acids, factors, junction, wang, expression, proteins, protein, codons, regulates, long, gehring, zhang, authors,

Topics {✒️}

post-termination ribosome recycling nonsense-mediated decay pathway month download article/chapter nonsense-mediated mrna decay nonsense-mediated rna decay nonsense-mediated decay approaches nonsense-mediated decay associates smg-1–upf1–erf1–erf3 complex unstable β-globin mrna wt1-mediated transcriptional activation mrna exon–exon junctions premature termination codons duchenne/becker muscular dystrophy tdp-43-induced motor paralysis exon-junction complex components exon-junction complex assembly exon–exon junction complex full-length transcriptome sequencing mrna-deficient β0 thalassemia tgf-ß signaling pathway neurodevelopmental disorder-causing mutation messenger rna surveillance nucleic acid-based approaches nonsense-mediated decay gagan kumar panigrahi nmd factors smg5–smg7 targeting messenger rna cytoplasmic mrna decay upf3b-mutant mouse model full article pdf post-transcriptional defects premature stop codons splicing factor srsf1 conserved ejc-binding motifs mrna surveillance complex asish kumar patro alternative splicing coupled anti-tumor immunogenicity mrna surveillance machinery long-day growth conditions bmc medical genomics exon-junction complex exon junction complex cytoplasmic mrna accumulation rna helicase upf1 gastric cancer cells exon-exon junctions neural stem cells upf1 atpase mutants privacy choices/manage cookies

Questions {❓}

Does the nonsense-mediated mRNA decay mechanism prevent the synthesis of truncated BRCA1, CHK2, and P53 proteins?
Long mutant dystrophins and variable phenotypes: Evasion of nonsense-mediated decay?
Nonsense-mediated decay in genetic disease: Friend or foe?

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      description:Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that is conserved across all eukaryotes ensuring the quality of transcripts by targeting messenger RNA (mRNA) harbouring premature stop codons. It regulates the gene expression by targeting aberrant mRNA carrying pre-termination codons (PTCs) and eliminates C-terminal truncated proteins. NMD distinguishes aberrant and non-aberrant transcript by looking after long 3′ UTRs and exon-junction complex (EJC) downstream of stop codon that indicate the presence of PTC. Therefore, NMD modulates cellular surveillance and eliminates the truncated proteins but if the PTC escapes the surveillance pathway it can lead to potential negative phenotype resulting in genetic diseases. The alternative splicing also contributes in formation of NMD-sensitive isoforms by introducing PTC. NMD plays a complex role in cancer, it can either aggravate or downregulates the tumour. Some tumours agitate NMD to deteriorate mRNAs encoding tumour suppressor proteins, stress response proteins and neoantigens. In other case, tumours suppress the NMD to encourage the expression of oncoproteins for tumour growth and survival. This mechanism augmented in the development of new therapeutics by PTC read-through mechanism and personalized medicine. Detailed studies on NMD surveillance will possibly lead towards development of strategies for improving human health aligning with United Nations sustainable development goals (SDG 3: Good health and well-being). The potential therapeutic applications of NMD pose a challenge in terms of safe and effective modulation. Understanding the complexities of NMD regulation and its interaction with other cellular processes can lead to the development of new interventions for various diseases.
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