We are analyzing https://link.springer.com/article/10.1007/s12033-024-01062-4.

Title:
Messenger RNA Surveillance: Current Understanding, Regulatory Mechanisms, and Future Implications | Molecular Biotechnology
Description:
Nonsense-mediated mRNA decay (NMD) is an evolutionarily conserved surveillance mechanism in eukaryotes primarily deployed to ensure RNA quality control by eliminating aberrant transcripts and also involved in modulating the expression of several physiological transcripts. NMD, the mRNA surveillance pathway, is a major form of gene regulation in eukaryotes. NMD serves as one of the most significant quality control mechanisms as it primarily scans the newly synthesized transcripts and differentiates the aberrant and non-aberrant transcripts. The synthesis of truncated proteins is restricted, which would otherwise lead to cellular dysfunctions. The up-frameshift factors (UPFs) play a central role in executing the NMD event, largely by recognizing and recruiting multiple protein factors that result in the decay of non-physiological mRNAs. NMD exhibits astounding variability in its ability across eukaryotes in an array of pathological and physiological contexts. The detailed understanding of NMD and the underlying molecular mechanisms remains blurred. This review outlines our current understanding of NMD, in regulating multifaceted cellular events during development and disease. It also attempts to identify unanswered questions that deserve further investigation. Graphical Abstract
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Keywords {🔍}

pubmed, article, google, scholar, cas, central, mrna, decay, nonsensemediated, molecular, cell, rna, upf, complex, biology, nature, nmd, smg, journal, human, development, exon, junction, protein, research, surveillance, genes, structural, gene, plant, panigrahi, huang, nonsense, mammalian, upfb, hir, genetics, maquat, embo, nucleic, wilkinson, control, expression, mrnas, kim, cells, izaurralde, conti, acids, pathway,

Topics {✒️}

month download article/chapter smg-1–upf1–erf1–erf3 complex smg-1-upf1-erf1-erf3 complex nonsense-mediated decay pathway nonsense-mediated mrna decay nonsense-mediated decay factors nonsense-mediated rna decay staufen-mediated mrna decay gagan kumar panigrahi upf3b/nmd-deficient lymphoblastoid cells nonsense-mediated decay serves nonsense immunoglobulin-mumrna depends pre-messenger rna splicing childhood onset schizophrenia rna-dependent atpase activity mrna exon-exon junctions smg7-mediated degradation pathways hnrnp l-dependent protection conserved ejc-binding motifs core ejc-upf3b complex smg8-smg9 complex identifies exon-junction complex assembly smg1-smg8-smg9 complex nonsense-mediated decay exon-junction complex components ejc-sr protein nexus nmd factors smg5-smg7 upf3-mediated regulatory switch post-translational regulatory switch mrna surveillance pathway messenger rna surveillance post-termination ribosome recycling pre-messenger rna intracellular calcium release protein quality control mrna surveillance complex mrna metabolism full article pdf mrna surveillance complexes upf3b-mutant mouse model potentiate mrna decay nonsensemediated mrna decay upf1 atpase mutants govern upf1 binding exon junction complex autoinhibitory state dependent exon junction complexes eliminating aberrant transcripts resistance gene transcripts long-day growth conditions

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         Biological Techniques
         Human Genetics
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