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Title:
Alterations in Antioxidant Enzymes During Aging in Humans | Molecular Biotechnology
Description:
The oxidative stress theory of aging offers the best mechanistic elucidation of the aging phenomenon and other age-related diseases. The susceptibility of an individual depends on the antioxidant status of the body. In humans, the antioxidant system includes a number of antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT), nonenzymatic antioxidants such as glutathione (GSH), protein βSH, ascorbic acid, and uric acid, and dietary antioxidants. Antioxidant enzymes form the first line of defense against reactive oxygen species. In an earlier report, we showed that the plasma antioxidant potential in humans decreases as a function of age and that there are compensatory mechanisms operating in the body which are induced to maintain the antioxidant capacity during aging. In the present study, we report the relationship between human aging and antioxidant enzymes SOD and CAT; we also correlate the activity of these enzymes with the antioxidant capacity of the plasma. Our results show a significantly higher plasma SOD and CAT activity in older individuals than in younger individuals. The induction in activity of SOD and CAT during human aging may be a compensatory response of the individual to an increased oxidative stress.
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syed ibrahim rizvi month download article/chapter oxidative stress-related damage full article pdf privacy choices/manage cookies malondialdehyde levels related free radical research age-related alterations antioxidant system includes erythrocyte antioxidant enzymes article rizvi age-related diseases superoxide anion radical increased oxidative stress oxidative stress parameters reactive oxygen species clinica chimica acta controlled diets high mouse skeletal muscles folin phenol reagent cardiac interfibriller mitochondria antioxidative enzyme activities conditions privacy policy oxidative stress theory related subjects oxidative stress markers therapeutic antioxidant interventions antioxidant enzymes form european economic area healthy women depends mitochondrial dna mutation antioxidant enzyme activities free radical biology plasma antioxidant potential accepting optional cookies free radical theory university grants commission antioxidant enzymes sod author information authors main content log check access instant access compensatory mechanisms operating superoxide dismutase york academy sciences journal finder publish article log human plasma catalase activities article cite
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headline:Alterations in Antioxidant Enzymes During Aging in Humans
description:The oxidative stress theory of aging offers the best mechanistic elucidation of the aging phenomenon and other age-related diseases. The susceptibility of an individual depends on the antioxidant status of the body. In humans, the antioxidant system includes a number of antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT), nonenzymatic antioxidants such as glutathione (GSH), protein βSH, ascorbic acid, and uric acid, and dietary antioxidants. Antioxidant enzymes form the first line of defense against reactive oxygen species. In an earlier report, we showed that the plasma antioxidant potential in humans decreases as a function of age and that there are compensatory mechanisms operating in the body which are induced to maintain the antioxidant capacity during aging. In the present study, we report the relationship between human aging and antioxidant enzymes SOD and CAT; we also correlate the activity of these enzymes with the antioxidant capacity of the plasma. Our results show a significantly higher plasma SOD and CAT activity in older individuals than in younger individuals. The induction in activity of SOD and CAT during human aging may be a compensatory response of the individual to an increased oxidative stress.
datePublished:2007-08-01T00:00:00Z
dateModified:2007-08-01T00:00:00Z
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Human aging
Oxidative stress
Superoxide dismutase
Catalase
Biotechnology
Biochemistry
general
Cell Biology
Protein Science
Biological Techniques
Human Genetics
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headline:Alterations in Antioxidant Enzymes During Aging in Humans
description:The oxidative stress theory of aging offers the best mechanistic elucidation of the aging phenomenon and other age-related diseases. The susceptibility of an individual depends on the antioxidant status of the body. In humans, the antioxidant system includes a number of antioxidant enzymes such as superoxide dismutase (SOD) and catalase (CAT), nonenzymatic antioxidants such as glutathione (GSH), protein βSH, ascorbic acid, and uric acid, and dietary antioxidants. Antioxidant enzymes form the first line of defense against reactive oxygen species. In an earlier report, we showed that the plasma antioxidant potential in humans decreases as a function of age and that there are compensatory mechanisms operating in the body which are induced to maintain the antioxidant capacity during aging. In the present study, we report the relationship between human aging and antioxidant enzymes SOD and CAT; we also correlate the activity of these enzymes with the antioxidant capacity of the plasma. Our results show a significantly higher plasma SOD and CAT activity in older individuals than in younger individuals. The induction in activity of SOD and CAT during human aging may be a compensatory response of the individual to an increased oxidative stress.
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Human aging
Oxidative stress
Superoxide dismutase
Catalase
Biotechnology
Biochemistry
general
Cell Biology
Protein Science
Biological Techniques
Human Genetics
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