We are analyzing https://link.springer.com/article/10.1007/s12032-025-02859-2.

Title:
Emerging roles and clinical perspectives of long noncoding RNAs in prostate cancer | Medical Oncology
Description:
Prostate cancer (PCa) is one of the most frequent cancers in males and one of the leading causes of cancer-related deaths globally. Despite advances in diagnosis and treatment, PCa continues to pose substantial hurdles, especially due to its potential to evolve into more aggressive and treatment-resistant types. Long noncoding RNAs (lncRNAs) are transcripts with more than 200 nucleotides that do not encode proteins and have been identified as pivotal regulators in PCa. They influence crucial cellular mechanisms such as cell cycle control, gene expression, and translation, and their dysregulation is linked to tumour growth, progression, and metastasis. Furthermore, lncRNAs modulate androgen receptor (AR) signalling and act as competitive endogenous RNAs (ceRNAs), sequestering microRNAs to alter target gene expression, therefore driving tumour progression. This review uniquely integrates recent advances in understanding the lncRNA-mediated regulatory networks, highlighting their roles in epigenetic, post-transcriptional regulations and key signalling pathways in PCa. It also underscores the emerging clinical applications of lncRNAs as predictive biomarkers and therapeutic targets, with a focus on personalised medicines. Despite the challenges posed by patient heterogeneity and lncRNAs
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We find it hard to spot revenue streams.

Many websites are intended to earn money, but some serve to share ideas or build connections. Websites exist for all kinds of purposes. This might be one of them. Link.springer.com might be plotting its profit, but the way they're doing it isn't detectable yet.

Keywords {🔍}

pubmed, cancer, article, google, scholar, prostate, cas, central, noncoding, long, lncrna, rnas, cell, rna, zhang, wang, promotes, chen, liu, mol, res, oncol, progression, signaling, lncrnas, pathway, proliferation, androgen, therapeutic, yang, research, potential, expression, int, zhou, gene, cells, biol, med, axis, linc, analysis, clinical, metastasis, sun, pca, cancers, identification, zhu, zhao,

Topics {✒️}

mir-7-5p/egfr/pi3k/akt/mtor signaling pathway trhde-as1/hsa-mir-449a/adamts5 axis targeting mir-212-5p/fzd5/wnt/β-catenin axis fak/pi3k/akt/gsk3β/snail pathway 7a-5p/egfr-related pathway regulates β-catenin-c-myc-glut1 axis mir-3173-5p/socs3/jak2/stat3 pathway regulating pten/pi3k/akt/mtor signaling lncrna-circrna-mirna-mrna cerna networks mediating pi3k/akt/mtor signaling wnt/β-catenin signaling pathway pi3k/akt/mtor signaling pathways androgen-receptor-mediated transcriptional program crispri-based genome-scale identification month download article/chapter pi3k/akt/mtor pathway wnt/β-catenin pathway wnt/β-catenin signaling lncrna tpt1-as1 promotes lncrna pitpna-as1 mediates mir-494-3p/stat3 axis inhibit nf-κb aactivation lncrna-mediated regulatory networks regulating akt/mtor pathway lncrna loxl1-as1/mir castration-resistant prostate cancer mir-324-3p/wnt2b axis mir-342-3p/cul4b axis mir-512-3p/hk-2 axis mitophagy-related lncrna signature saradhadevi muthukrishnan contributed noncoding rna therapeutics—challenges phlpp/fkbp51/ikkα complex mir-29a/29b/col3a1 cancer-related deaths globally cancer-related carbonic anhydrases modulating mir-27b-3p emerging rna-based therapeutic sponging mir-181a-5p triple-negative breast cancer activating p38-mapk pathway promotes cell proliferation multi-view clustering algorithms patient-derived xenograft models stimulating lif/lifr expression prune2/pca3 genetic axis jak2/stat3 pathway writing—original draft preparation pi3k/akt pathway pi3k/akt signaling

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Emerging roles and clinical perspectives of long noncoding RNAs in prostate cancer
         description:Prostate cancer (PCa) is one of the most frequent cancers in males and one of the leading causes of cancer-related deaths globally. Despite advances in diagnosis and treatment, PCa continues to pose substantial hurdles, especially due to its potential to evolve into more aggressive and treatment-resistant types. Long noncoding RNAs (lncRNAs) are transcripts with more than 200 nucleotides that do not encode proteins and have been identified as pivotal regulators in PCa. They influence crucial cellular mechanisms such as cell cycle control, gene expression, and translation, and their dysregulation is linked to tumour growth, progression, and metastasis. Furthermore, lncRNAs modulate androgen receptor (AR) signalling and act as competitive endogenous RNAs (ceRNAs), sequestering microRNAs to alter target gene expression, therefore driving tumour progression. This review uniquely integrates recent advances in understanding the lncRNA-mediated regulatory networks, highlighting their roles in epigenetic, post-transcriptional regulations and key signalling pathways in PCa. It also underscores the emerging clinical applications of lncRNAs as predictive biomarkers and therapeutic targets, with a focus on personalised medicines. Despite the challenges posed by patient heterogeneity and lncRNAs' complex regulatory networks, ongoing research into lncRNAs holds the promise for improving early diagnosis and advancing the development of more effective, personalised therapeutic strategies. Collectively, this review summarises the current knowledge on growing roles of lncRNAs in PCa pathogenesis, clinical relevance and their therapeutic potential and provides potential insights and future directions for translating lncRNA research into effective clinical applications.
         datePublished:2025-06-27T00:00:00Z
         dateModified:2025-06-27T00:00:00Z
         pageStart:1
         pageEnd:22
         sameAs:https://doi.org/10.1007/s12032-025-02859-2
         keywords:
            Prostate cancer
            Long noncoding RNAs
            Biomarkers
            Prognostic indicators
            Therapeutic targets
            Oncology
            Hematology
            Pathology
            Internal Medicine
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-025-02859-2/MediaObjects/12032_2025_2859_Fig1_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-025-02859-2/MediaObjects/12032_2025_2859_Fig2_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-025-02859-2/MediaObjects/12032_2025_2859_Fig3_HTML.png
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-025-02859-2/MediaObjects/12032_2025_2859_Fig4_HTML.png
         isPartOf:
            name:Medical Oncology
            issn:
               1559-131X
            volumeNumber:42
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Rajarethinam Kumar
               affiliation:
                     name:Bharathiar University
                     address:
                        name:Translational Genomics Research Laboratory, Department of Biochemistry, Bharathiar University, Coimbatore, India
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Saradhadevi Muthukrishnan
               affiliation:
                     name:Bharathiar University
                     address:
                        name:Translational Genomics Research Laboratory, Department of Biochemistry, Bharathiar University, Coimbatore, India
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Emerging roles and clinical perspectives of long noncoding RNAs in prostate cancer
      description:Prostate cancer (PCa) is one of the most frequent cancers in males and one of the leading causes of cancer-related deaths globally. Despite advances in diagnosis and treatment, PCa continues to pose substantial hurdles, especially due to its potential to evolve into more aggressive and treatment-resistant types. Long noncoding RNAs (lncRNAs) are transcripts with more than 200 nucleotides that do not encode proteins and have been identified as pivotal regulators in PCa. They influence crucial cellular mechanisms such as cell cycle control, gene expression, and translation, and their dysregulation is linked to tumour growth, progression, and metastasis. Furthermore, lncRNAs modulate androgen receptor (AR) signalling and act as competitive endogenous RNAs (ceRNAs), sequestering microRNAs to alter target gene expression, therefore driving tumour progression. This review uniquely integrates recent advances in understanding the lncRNA-mediated regulatory networks, highlighting their roles in epigenetic, post-transcriptional regulations and key signalling pathways in PCa. It also underscores the emerging clinical applications of lncRNAs as predictive biomarkers and therapeutic targets, with a focus on personalised medicines. Despite the challenges posed by patient heterogeneity and lncRNAs' complex regulatory networks, ongoing research into lncRNAs holds the promise for improving early diagnosis and advancing the development of more effective, personalised therapeutic strategies. Collectively, this review summarises the current knowledge on growing roles of lncRNAs in PCa pathogenesis, clinical relevance and their therapeutic potential and provides potential insights and future directions for translating lncRNA research into effective clinical applications.
      datePublished:2025-06-27T00:00:00Z
      dateModified:2025-06-27T00:00:00Z
      pageStart:1
      pageEnd:22
      sameAs:https://doi.org/10.1007/s12032-025-02859-2
      keywords:
         Prostate cancer
         Long noncoding RNAs
         Biomarkers
         Prognostic indicators
         Therapeutic targets
         Oncology
         Hematology
         Pathology
         Internal Medicine
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-025-02859-2/MediaObjects/12032_2025_2859_Fig1_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-025-02859-2/MediaObjects/12032_2025_2859_Fig2_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-025-02859-2/MediaObjects/12032_2025_2859_Fig3_HTML.png
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-025-02859-2/MediaObjects/12032_2025_2859_Fig4_HTML.png
      isPartOf:
         name:Medical Oncology
         issn:
            1559-131X
         volumeNumber:42
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Rajarethinam Kumar
            affiliation:
                  name:Bharathiar University
                  address:
                     name:Translational Genomics Research Laboratory, Department of Biochemistry, Bharathiar University, Coimbatore, India
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Saradhadevi Muthukrishnan
            affiliation:
                  name:Bharathiar University
                  address:
                     name:Translational Genomics Research Laboratory, Department of Biochemistry, Bharathiar University, Coimbatore, India
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Medical Oncology
      issn:
         1559-131X
      volumeNumber:42
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Bharathiar University
      address:
         name:Translational Genomics Research Laboratory, Department of Biochemistry, Bharathiar University, Coimbatore, India
         type:PostalAddress
      name:Bharathiar University
      address:
         name:Translational Genomics Research Laboratory, Department of Biochemistry, Bharathiar University, Coimbatore, India
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Rajarethinam Kumar
      affiliation:
            name:Bharathiar University
            address:
               name:Translational Genomics Research Laboratory, Department of Biochemistry, Bharathiar University, Coimbatore, India
               type:PostalAddress
            type:Organization
      name:Saradhadevi Muthukrishnan
      affiliation:
            name:Bharathiar University
            address:
               name:Translational Genomics Research Laboratory, Department of Biochemistry, Bharathiar University, Coimbatore, India
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Translational Genomics Research Laboratory, Department of Biochemistry, Bharathiar University, Coimbatore, India
      name:Translational Genomics Research Laboratory, Department of Biochemistry, Bharathiar University, Coimbatore, India
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(523)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.18s.

LINK . SPRINGER . COM {}