We are analyzing https://link.springer.com/article/10.1007/s12032-012-0360-3.

Title:
Reduced expression of Dicer11 is associated with poor prognosis in patients with nasopharyngeal carcinoma | Medical Oncology
Description:
Dicer11 plays an important role in generation of microRNA and is dysregulated in a variety of human cancers. The purpose of this study was to evaluate Dicer11 expression and its prognostic value in nasopharyngeal carcinoma (NPC). The protein expression of Dicer1 was examined by immunohistochemistry in 276 NPC specimens, and the mRNA levels of Dicer1 were analyzed by qRT-PCR in 56 NPC and 11 nasopharyngitis tissues. Cox regression analysis was used to identify independent prognostic factors, and a prognostic score model was constructed for survival prediction. Expression of Dicer1 was downregulated in NPC tissues at both the mRNA and the protein levels, and there was a notable positive correlation between the expression levels of Dicer1 mRNA and protein. Low Dicer1 expression was positively correlated with distant metastasis (P < 0.01) and death (P = 0.01). In addition, low expression of Dicer1 was significantly associated with poorer overall survival (HR, 2.32; 95 % CI 1.30–4.14; P < 0.01) and poorer distant metastasis-free survival (HR, 2.56; 95 % CI 1.39–4.74; P < 0.01). Furthermore, multivariate analysis showed that low expression of Dicer1 and tumor-node-metastasis (TNM) stage was independent prognostic indicators for NPC patients. A prognostic score model combining the Dicer1 expression and TNM stage had a better prognostic value than the TNM stage alone model or Dicer1 expression alone model (P < 0.05). Dicer1 was downregulated in NPC tissues at both the mRNA and the protein levels, and low expression of Dicer1 could be served as novel prognostic biomarker for NPC patients.
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article, scholar, google, pubmed, cancer, dicer, cas, carcinoma, nasopharyngeal, expression, prognostic, patients, oncol, liu, survival, china, microrna, chen, npc, access, clin, oncology, int, res, privacy, cookies, content, analysis, poor, prognosis, cui, sun, protein, mrna, metastasis, staging, biol, key, information, publish, research, search, reduced, huang, wang, levels, tissues, model, low, rna,

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epstein-barr virus infection tumor-node-metastasis month download article/chapter hui-yun wang bi-jun huang promote anti-tumoral immunity concurrent chemotherapy-radiotherapy compared paraffin-embedded lymphatic tissues progression-free survival analysis ajcc staging system author information authors full article pdf related subjects privacy choices/manage cookies gastric cancer progression microrna targeting dicer1 jun ma human breast cancers estrogen receptor-positive reduced expression primary nasopharyngeal carcinoma colorectal cancer check access instant access article liu rui-xue cui favorable prognostic group oestrogen receptor expression ovarian cancer-link ying sun head neck technological innovation program global cancer statistics clin cancer res nasopharyngeal carcinoma patients prognostic biomarker independent prognostic indicators lung cancer patients european economic area cox regression analysis multivariate analysis showed magnetic resonance imaging graphical primer design den boon ja prostate adenocarcinoma dimensional radiotherapy influence esophageal cancer patients conditions privacy policy adverse biomarker evaluate dicer11 expression

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How does intensity-modulated radiotherapy versus conventional two-dimensional radiotherapy influence the treatment results in nasopharyngeal carcinoma patients?

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         description:Dicer11 plays an important role in generation of microRNA and is dysregulated in a variety of human cancers. The purpose of this study was to evaluate Dicer11 expression and its prognostic value in nasopharyngeal carcinoma (NPC). The protein expression of Dicer1 was examined by immunohistochemistry in 276 NPC specimens, and the mRNA levels of Dicer1 were analyzed by qRT-PCR in 56 NPC and 11 nasopharyngitis tissues. Cox regression analysis was used to identify independent prognostic factors, and a prognostic score model was constructed for survival prediction. Expression of Dicer1 was downregulated in NPC tissues at both the mRNA and the protein levels, and there was a notable positive correlation between the expression levels of Dicer1 mRNA and protein. Low Dicer1 expression was positively correlated with distant metastasis (P < 0.01) and death (P = 0.01). In addition, low expression of Dicer1 was significantly associated with poorer overall survival (HR, 2.32; 95 % CI 1.30–4.14; P < 0.01) and poorer distant metastasis-free survival (HR, 2.56; 95 % CI 1.39–4.74; P < 0.01). Furthermore, multivariate analysis showed that low expression of Dicer1 and tumor-node-metastasis (TNM) stage was independent prognostic indicators for NPC patients. A prognostic score model combining the Dicer1 expression and TNM stage had a better prognostic value than the TNM stage alone model or Dicer1 expression alone model (P < 0.05). Dicer1 was downregulated in NPC tissues at both the mRNA and the protein levels, and low expression of Dicer1 could be served as novel prognostic biomarker for NPC patients.
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      description:Dicer11 plays an important role in generation of microRNA and is dysregulated in a variety of human cancers. The purpose of this study was to evaluate Dicer11 expression and its prognostic value in nasopharyngeal carcinoma (NPC). The protein expression of Dicer1 was examined by immunohistochemistry in 276 NPC specimens, and the mRNA levels of Dicer1 were analyzed by qRT-PCR in 56 NPC and 11 nasopharyngitis tissues. Cox regression analysis was used to identify independent prognostic factors, and a prognostic score model was constructed for survival prediction. Expression of Dicer1 was downregulated in NPC tissues at both the mRNA and the protein levels, and there was a notable positive correlation between the expression levels of Dicer1 mRNA and protein. Low Dicer1 expression was positively correlated with distant metastasis (P < 0.01) and death (P = 0.01). In addition, low expression of Dicer1 was significantly associated with poorer overall survival (HR, 2.32; 95 % CI 1.30–4.14; P < 0.01) and poorer distant metastasis-free survival (HR, 2.56; 95 % CI 1.39–4.74; P < 0.01). Furthermore, multivariate analysis showed that low expression of Dicer1 and tumor-node-metastasis (TNM) stage was independent prognostic indicators for NPC patients. A prognostic score model combining the Dicer1 expression and TNM stage had a better prognostic value than the TNM stage alone model or Dicer1 expression alone model (P < 0.05). Dicer1 was downregulated in NPC tissues at both the mRNA and the protein levels, and low expression of Dicer1 could be served as novel prognostic biomarker for NPC patients.
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      name:State Key Laboratory of Oncology in South China, Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of China
      name:State Key Laboratory of Oncology in South China, Department of Experiment Research, Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of China
      name:State Key Laboratory of Oncology in South China, Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, People’s Republic of China
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