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month download article/chapter triple-negative breast cancer called triple-negative phenotype hab18g/cd147-mediated metastasis process shorter progression-free survival perou cm upregulated emm-prin/cd147 dabei tang prognostic factor triple-negative/basal triple negative tumors full article pdf breast cancer res tumor cell surface human breast tumors privacy choices/manage cookies author information authors mol cell biochem human hepatoma cells article number 335 hepatocellular carcinoma cells adenovirus-mediated transfer california cancer registry mol cancer ther matrix metalloproteinase production clin cancer res mammary gland fibroma health science center cell surface regulator stem cell biology bmc cancer check access instant access human malignancies based serous ovarian carcinoma salivary duct carcinoma breast cancer european economic area van de rijn ven de rijn systemic lupus erythematosus oncobiology key lab medical oncology harbin medical university public health college conditions privacy policy gene expression profiling gene expression patterns e-cadherin expression cyclooxygenase-2 expression correlates

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         headline:High expression of CD147 and MMP-9 is correlated with poor prognosis of triple-negative breast cancer (TNBC) patients
         description:The aim of this study was to investigate expression of CD147 and MMP-9 in triple-negative breast cancer (TNBC) so as to determine whether these two proteins may be correlated with poor prognosis of TNBC patients. We examined the expression levels of the CD147 and MMP-9 in 127 patients with TNBC and 30 patients with mammary gland fibroma using immunohistochemical staining before any treatments. Furthermore, we analyzed the correlation between the expression of these two proteins and various clinicopathologic factors including survival status of patients with TNBC. Positive stain of CD147 and MMP-9 was observed in all samples of TNBC. A statistically positive correlation was observed between the expression levels of CD147 and MMP-9 in TNBC tissues. The incidences of high expression were 48.0 % for CD147 and 53.5 % for MMP-9 in 127 TNBC tissues, respectively. High expression of either CD147 or MMP-9 was significantly correlated with clinical feature and shorter progression-free survival (PFS) (PCD147 = 0.039; PMMP-9 = 0.017) and overall survival (OS) (PCD147 = 0.037; PMMP-9 = 0.023). The expression levels of CD147 and MMP-9 are positively correlated with invasion, metastasis and shorter PFS/OS of TNBC. Patients with high expression of CD147 and MMP-9 had poor prognosis than TNBC patients with low expression.
         datePublished:2012-12-22T00:00:00Z
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            MMP-9
            Triple-negative breast cancer
            Cancer prognosis
            Oncology
            Hematology
            Pathology
            Internal Medicine
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      headline:High expression of CD147 and MMP-9 is correlated with poor prognosis of triple-negative breast cancer (TNBC) patients
      description:The aim of this study was to investigate expression of CD147 and MMP-9 in triple-negative breast cancer (TNBC) so as to determine whether these two proteins may be correlated with poor prognosis of TNBC patients. We examined the expression levels of the CD147 and MMP-9 in 127 patients with TNBC and 30 patients with mammary gland fibroma using immunohistochemical staining before any treatments. Furthermore, we analyzed the correlation between the expression of these two proteins and various clinicopathologic factors including survival status of patients with TNBC. Positive stain of CD147 and MMP-9 was observed in all samples of TNBC. A statistically positive correlation was observed between the expression levels of CD147 and MMP-9 in TNBC tissues. The incidences of high expression were 48.0 % for CD147 and 53.5 % for MMP-9 in 127 TNBC tissues, respectively. High expression of either CD147 or MMP-9 was significantly correlated with clinical feature and shorter progression-free survival (PFS) (PCD147 = 0.039; PMMP-9 = 0.017) and overall survival (OS) (PCD147 = 0.037; PMMP-9 = 0.023). The expression levels of CD147 and MMP-9 are positively correlated with invasion, metastasis and shorter PFS/OS of TNBC. Patients with high expression of CD147 and MMP-9 had poor prognosis than TNBC patients with low expression.
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         CD147
         MMP-9
         Triple-negative breast cancer
         Cancer prognosis
         Oncology
         Hematology
         Pathology
         Internal Medicine
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