We are analyzing https://link.springer.com/article/10.1007/s12032-011-9860-9.

Title:
Overexpression of Nanog protein is associated with poor prognosis in gastric adenocarcinoma | Medical Oncology
Description:
Nanog, a key transcription factor in self-renewal and pluripotency of embryonic stem cells, has been proved to play a novel role in solid tumor development. Here, we investigated Nanog protein expression in retrospective clinical samples of 105 patients underwent resective surgery for gastric adenocarcinoma. We found that Nanog protein immunostaining in tumor tissues was stronger than that in their corresponding non-dysplastic tissues. However, no statistical difference of Nanog protein expression between tumor tissues and metastatic lymph nodes was found (P = 0.143). Interestingly, overexpression of Nanog protein was correlated with advanced clinical stage of patients with gastric adenocarcinoma (P = 0.006). And Nanog protein expression was correlated with lymph node status (P = 0.004), infiltrating extent (P = 0.001), and differentiation (P = 0.000) of patients with gastric adenocarcinoma. Survival analysis showed that overexpression of Nanog protein in gastric cancer patients predicted a poorer prognosis (P = 0.000). Our data first demonstrated a potential diagnostic and prognostic role of Nanog for gastric adenocarcinoma.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,626,182 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure if the website is profiting.

The purpose of some websites isn't monetary gain; they're meant to inform, educate, or foster collaboration. Everyone has unique reasons for building websites. This could be an example. Link.springer.com might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

article, google, scholar, cancer, pubmed, cas, nanog, cell, gastric, stem, cells, adenocarcinoma, embryonic, expression, breast, human, protein, prognosis, pluripotency, tumor, access, res, privacy, cookies, content, overexpression, poor, lin, clinical, patients, gene, data, publish, research, search, medical, ding, jianming, factor, tissues, oct, mol, nature, information, log, journal, february, ting, yanqing, transcription,

Topics {✒️}

yan-qing ding & jian-ming li tgfbeta/activin-mediated smad signaling stem-cell-abundant proteins nanog month download article/chapter jian-ming li breast cancer–independent roles full article pdf breast cancer research oral cancer stem related subjects embryonic stem cells cell stem cell key transcription factor solid tumor development privacy choices/manage cookies original human tumor lymph node status high expression levels southern medical university metastatic lymph nodes nanog gene transcription human somatic cells nanog-mediated reversal prostate cancer cells global cancer statistics endocr relat cancer cancer biol ther breast cancer res pluripotency sustaining factor nanog regulatory regions gastrointest cancer res clin cancer res mol biol cell mol cell biol gastric adenocarcinoma bmc cancer european economic area future lies ahead el-omar em early distant recurrences rajpert-de meyts frequent kit mutations sampsell-barron tl article lin nanog protein expression functional expression cloning conditions privacy policy worse patients’ survival nanog protein immunostaining survival analysis showed

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Overexpression of Nanog protein is associated with poor prognosis in gastric adenocarcinoma
         description:Nanog, a key transcription factor in self-renewal and pluripotency of embryonic stem cells, has been proved to play a novel role in solid tumor development. Here, we investigated Nanog protein expression in retrospective clinical samples of 105 patients underwent resective surgery for gastric adenocarcinoma. We found that Nanog protein immunostaining in tumor tissues was stronger than that in their corresponding non-dysplastic tissues. However, no statistical difference of Nanog protein expression between tumor tissues and metastatic lymph nodes was found (P = 0.143). Interestingly, overexpression of Nanog protein was correlated with advanced clinical stage of patients with gastric adenocarcinoma (P = 0.006). And Nanog protein expression was correlated with lymph node status (P = 0.004), infiltrating extent (P = 0.001), and differentiation (P = 0.000) of patients with gastric adenocarcinoma. Survival analysis showed that overexpression of Nanog protein in gastric cancer patients predicted a poorer prognosis (P = 0.000). Our data first demonstrated a potential diagnostic and prognostic role of Nanog for gastric adenocarcinoma.
         datePublished:2011-02-20T00:00:00Z
         dateModified:2011-02-20T00:00:00Z
         pageStart:878
         pageEnd:885
         sameAs:https://doi.org/10.1007/s12032-011-9860-9
         keywords:
            Nanog
            Gastric adenocarcinoma
            Immunohistochemistry
            Diagnosis
            Prognosis
            Clinicopathological characteristics
            Oncology
            Hematology
            Pathology
            Internal Medicine
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-011-9860-9/MediaObjects/12032_2011_9860_Fig1_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-011-9860-9/MediaObjects/12032_2011_9860_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-011-9860-9/MediaObjects/12032_2011_9860_Fig3_HTML.gif
         isPartOf:
            name:Medical Oncology
            issn:
               1559-131X
               1357-0560
            volumeNumber:29
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Ting Lin
               affiliation:
                     name:Southern Medical University
                     address:
                        name:Department of Pathology and Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
                     name:Southern Medical University
                     address:
                        name:Department of First School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Yan-Qing Ding
               affiliation:
                     name:Southern Medical University
                     address:
                        name:Department of Pathology and Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
                     name:Southern Medical University
                     address:
                        name:Department of First School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Jian-Ming Li
               affiliation:
                     name:Southern Medical University
                     address:
                        name:Department of Pathology and Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
                     name:Southern Medical University
                     address:
                        name:Department of First School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Overexpression of Nanog protein is associated with poor prognosis in gastric adenocarcinoma
      description:Nanog, a key transcription factor in self-renewal and pluripotency of embryonic stem cells, has been proved to play a novel role in solid tumor development. Here, we investigated Nanog protein expression in retrospective clinical samples of 105 patients underwent resective surgery for gastric adenocarcinoma. We found that Nanog protein immunostaining in tumor tissues was stronger than that in their corresponding non-dysplastic tissues. However, no statistical difference of Nanog protein expression between tumor tissues and metastatic lymph nodes was found (P = 0.143). Interestingly, overexpression of Nanog protein was correlated with advanced clinical stage of patients with gastric adenocarcinoma (P = 0.006). And Nanog protein expression was correlated with lymph node status (P = 0.004), infiltrating extent (P = 0.001), and differentiation (P = 0.000) of patients with gastric adenocarcinoma. Survival analysis showed that overexpression of Nanog protein in gastric cancer patients predicted a poorer prognosis (P = 0.000). Our data first demonstrated a potential diagnostic and prognostic role of Nanog for gastric adenocarcinoma.
      datePublished:2011-02-20T00:00:00Z
      dateModified:2011-02-20T00:00:00Z
      pageStart:878
      pageEnd:885
      sameAs:https://doi.org/10.1007/s12032-011-9860-9
      keywords:
         Nanog
         Gastric adenocarcinoma
         Immunohistochemistry
         Diagnosis
         Prognosis
         Clinicopathological characteristics
         Oncology
         Hematology
         Pathology
         Internal Medicine
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-011-9860-9/MediaObjects/12032_2011_9860_Fig1_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-011-9860-9/MediaObjects/12032_2011_9860_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs12032-011-9860-9/MediaObjects/12032_2011_9860_Fig3_HTML.gif
      isPartOf:
         name:Medical Oncology
         issn:
            1559-131X
            1357-0560
         volumeNumber:29
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Ting Lin
            affiliation:
                  name:Southern Medical University
                  address:
                     name:Department of Pathology and Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
                  name:Southern Medical University
                  address:
                     name:Department of First School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Yan-Qing Ding
            affiliation:
                  name:Southern Medical University
                  address:
                     name:Department of Pathology and Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
                  name:Southern Medical University
                  address:
                     name:Department of First School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jian-Ming Li
            affiliation:
                  name:Southern Medical University
                  address:
                     name:Department of Pathology and Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
                  name:Southern Medical University
                  address:
                     name:Department of First School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Medical Oncology
      issn:
         1559-131X
         1357-0560
      volumeNumber:29
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Southern Medical University
      address:
         name:Department of Pathology and Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
         type:PostalAddress
      name:Southern Medical University
      address:
         name:Department of First School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China
         type:PostalAddress
      name:Southern Medical University
      address:
         name:Department of Pathology and Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
         type:PostalAddress
      name:Southern Medical University
      address:
         name:Department of First School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China
         type:PostalAddress
      name:Southern Medical University
      address:
         name:Department of Pathology and Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
         type:PostalAddress
      name:Southern Medical University
      address:
         name:Department of First School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Ting Lin
      affiliation:
            name:Southern Medical University
            address:
               name:Department of Pathology and Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
               type:PostalAddress
            type:Organization
            name:Southern Medical University
            address:
               name:Department of First School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Yan-Qing Ding
      affiliation:
            name:Southern Medical University
            address:
               name:Department of Pathology and Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
               type:PostalAddress
            type:Organization
            name:Southern Medical University
            address:
               name:Department of First School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Jian-Ming Li
      affiliation:
            name:Southern Medical University
            address:
               name:Department of Pathology and Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
               type:PostalAddress
            type:Organization
            name:Southern Medical University
            address:
               name:Department of First School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Pathology and Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
      name:Department of First School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China
      name:Department of Pathology and Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
      name:Department of First School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China
      name:Department of Pathology and Guangdong Provincial Key Laboratory of Molecular Tumor Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China
      name:Department of First School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(121)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.35s.

LINK . SPRINGER . COM {}