We are analyzing https://link.springer.com/article/10.1007/s12032-011-9855-6.

Title:
Second-line chemotherapy in metastatic docetaxel-resistant prostate cancer: a review | Medical Oncology
Description:
The results of cytotoxic therapy in the second-line setting of metastatic castration-resistant prostate cancer have demonstrated that disease is poorly controlled after taxane resistance with a time to progression of 3 months or less. Many trials of second-line chemotherapy have been disappointing. However, most of patients with docetaxel-pretreated castration-resistant disease receive a second-line chemotherapy. Molecular mechanism of castration resistance and docetaxel resistance is resumed, and clinical trials of second-line chemotherapy after docetaxel progression are reviewed. Reintroduction of docetaxel after a drug-free interval is an active treatment in docetaxel-pretreated patients, and only recently a prospective study documented a survival benefit of 2.4 months after second-line taxane-based chemotherapy of metastatic docetaxel-resistant prostate cancer. Although a second-line chemotherapy with a taxane could improve overall survival, a change of biology of castration-resistant prostate cancer after docetaxel is suggested, as inferred by the renewed hormonal sensitivity, whose role on survival remains unknown, and from the activity of antiangiogenic drugs.
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Keywords {🔍}

cancer, prostate, google, scholar, article, pubmed, docetaxel, cas, chemotherapy, patients, oncol, phase, castrationresistant, metastatic, study, clin, secondline, hormonerefractory, therapy, mitoxantrone, prednisone, trial, refractory, abstract, combination, proc, genitourinary, cancers, symposium, poster, session, treatment, survival, crpc, androgenindependent, androgen, randomized, hormone, oncology, docetaxelresistant, results, resistance, advanced, urol, res, ryan, colloca, progression, docetaxelpretreated, receptor,

Topics {✒️}

month download article/chapter castration-resistant prostate cancer hormone-resistant prostate cancer hormone-refractory prostate cancer castrate-resistant prostate cancer androgen-independent prostate cancer absolute prostate-specific antigen docetaxel-refractory prostate cancer docetaxel-resistant breast cancer anti-il-6 monoclonal antibody metastatic castration-resistant continued androgen-deprivation therapy double-blinded randomized comparison metastatic prostate cancer 2nd/3rd line therapy drug-free interval randomised open-label trial initial docetaxel-based chemotherapy 1st-line docetaxel therapy giuseppe colloca metastatic tumor growth de bono js primary prostate cancer weekly high-dose calcitriol advanced prostate cancer docetaxel/carboplatin-based chemotherapy full article pdf line taxane-based chemotherapy related subjects article colloca clin prostate cancer castration-resistance crpc privacy choices/manage cookies androgen ablation therapy secondary hormonal therapy androgen receptor mutations androgen receptor antagonists human prostate carcinoma docetaxel-based therapy author information authors cancer chemother pharmacol genes potentially involved castration resistance strong independent predictor high-dose calcitriol canadian randomized trial docetaxel-based chemotherapy taxane-based chemotherapy clin cancer res prior taxane therapy

Questions {❓}

Chemotherapy in androgen-independent prostate cancer (AIPC): what’s next after taxane progression?
First- and second-line chemotherapy with docetaxel or mitoxantrone in patients with hormone-refractory prostate cancer: does sequence matter?

Schema {🗺️}

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         description:The results of cytotoxic therapy in the second-line setting of metastatic castration-resistant prostate cancer have demonstrated that disease is poorly controlled after taxane resistance with a time to progression of 3 months or less. Many trials of second-line chemotherapy have been disappointing. However, most of patients with docetaxel-pretreated castration-resistant disease receive a second-line chemotherapy. Molecular mechanism of castration resistance and docetaxel resistance is resumed, and clinical trials of second-line chemotherapy after docetaxel progression are reviewed. Reintroduction of docetaxel after a drug-free interval is an active treatment in docetaxel-pretreated patients, and only recently a prospective study documented a survival benefit of 2.4 months after second-line taxane-based chemotherapy of metastatic docetaxel-resistant prostate cancer. Although a second-line chemotherapy with a taxane could improve overall survival, a change of biology of castration-resistant prostate cancer after docetaxel is suggested, as inferred by the renewed hormonal sensitivity, whose role on survival remains unknown, and from the activity of antiangiogenic drugs.
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      headline:Second-line chemotherapy in metastatic docetaxel-resistant prostate cancer: a review
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