We are analyzing https://link.springer.com/article/10.1007/s12029-021-00714-x.

Title:
Hepatitis B/D-Related Hepatocellular Carcinoma. A Clinical Literature Review | Journal of Gastrointestinal Cancer
Description:
Aim Given the current literature data, this article aims to shed light on the epidemiological and clinical effects of HBV, as well as its impact on the development of hepatocellular carcinoma (HCC). Methods A review of the English language literature based on a MEDLINE (PubMed) database was searched. The keywords were cirrhosis, hepatocellular carcinoma, epidemiology, hepatitis delta virus, hepatitis B virus, and co-infection. All references from retrieved papers were reviewed systematically to find additional collection of reports. Results The study has broadly confirmed the contribution of HDV viremia to liver disease and cirrhosis. However, uncertainty over the mechanism of action on HCC development remains. As the recent data has demonstrated, the HCC-HDV has a unique molecular profile which is distinct from that of HBV-HCC. Conclusion Owing to the dependence of HDV on HBV, it is not clear whether HCC is a consequence of the cumulative effect of both HBV and HDV, an effect of the underlying cirrhosis, or a direct oncogenic effect of HDV. Many questions concerning the oncogenic role of HDV remain unanswered. To better understand the role of HDV in carcinogenesis, studies at the molecular level that consider genotype differences should be increased. Multicenter, high-volume, and prospective studies that compare HBV/HDV co-infected and HBV-infected individuals will be pivotal in determining the oncogenic role of HDV.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Social Networks

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We see no obvious way the site makes money.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Link.springer.com could be secretly minting cash, but we can't detect the process.

Keywords {🔍}

hepatitis, article, pubmed, google, scholar, virus, delta, hepatocellular, cas, carcinoma, cancer, liver, published, infection, hdv, chronic, clinical, hepatol, cirrhosis, patients, viral, review, baskiran, study, prevalence, content, data, research, coinfection, central, privacy, cookies, journal, search, epidemiology, disease, effect, role, genotype, hepatology, httpsdoiorgs, chen, infect, httpsdoiorgjjhep, outcomes, gastroenterol, information, publish, literature, atay,

Topics {✒️}

month download article/chapter /d-related hepatocellular carcinoma full article pdf privacy choices/manage cookies long-term clinical outcomes bdy conducted search long-term follow high serum levels liver-related outcomes additional information publisher' clinical literature review current literature data human viral oncogenesis european economic area hepatic decompensation events cell host microbe secondary care centers peruvian amazon basin hek-293 cells induced souza filho ja consensus commercial kit aliment pharmacol ther pinheiro borzacov lm ethics declarations conflict liver transplantation hepatitis delta antibodies virus endemic area primary liver cancer conditions privacy policy national vaccination program hepatitis delta virus gastrointestinal cancer aims cancer hallmarks analysis semin liver dis long-term study chronic delta hepatitis chronic hepatitis delta liver cancer hepatitis delta virus infection hepatitis delta prevalence unique molecular profile emerg microbes infect virus-infected mongolians accepting optional cookies hepatitis delta infection article journal article aims chronic hepatitis type su cw gene expression profiling

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Hepatitis B/D-Related Hepatocellular Carcinoma. A Clinical Literature Review
         description:Given the current literature data, this article aims to shed light on the epidemiological and clinical effects of HBV, as well as its impact on the development of hepatocellular carcinoma (HCC). A review of the English language literature based on a MEDLINE (PubMed) database was searched. The keywords were cirrhosis, hepatocellular carcinoma, epidemiology, hepatitis delta virus, hepatitis B virus, and co-infection. All references from retrieved papers were reviewed systematically to find additional collection of reports. The study has broadly confirmed the contribution of HDV viremia to liver disease and cirrhosis. However, uncertainty over the mechanism of action on HCC development remains. As the recent data has demonstrated, the HCC-HDV has a unique molecular profile which is distinct from that of HBV-HCC. Owing to the dependence of HDV on HBV, it is not clear whether HCC is a consequence of the cumulative effect of both HBV and HDV, an effect of the underlying cirrhosis, or a direct oncogenic effect of HDV. Many questions concerning the oncogenic role of HDV remain unanswered. To better understand the role of HDV in carcinogenesis, studies at the molecular level that consider genotype differences should be increased. Multicenter, high-volume, and prospective studies that compare HBV/HDV co-infected and HBV-infected individuals will be pivotal in determining the oncogenic role of HDV.
         datePublished:2021-10-06T00:00:00Z
         dateModified:2021-10-06T00:00:00Z
         pageStart:1192
         pageEnd:1197
         sameAs:https://doi.org/10.1007/s12029-021-00714-x
         keywords:
            Hepatocellular carcinoma
            Cirrhosis
            Hepatitis delta virus
            Hepatitis B virus
            Epidemiology
            Co-infection
            Oncology
            Gastroenterology
            Radiotherapy
            Cancer Research
            Internal Medicine
         image:
         isPartOf:
            name:Journal of Gastrointestinal Cancer
            issn:
               1941-6636
               1941-6628
            volumeNumber:52
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer US
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:A. Baskiran
               affiliation:
                     name:Inonu University Turgut Ozal Medical Center, Institute of Liver Transplantation
                     address:
                        name:Department of General Surgery, Faculty of Medicine, Inonu University Turgut Ozal Medical Center, Institute of Liver Transplantation, Malatya, Turkey
                        type:PostalAddress
                     type:Organization
               type:Person
               name:A. Atay
               url:http://orcid.org/0000-0001-8163-2357
               affiliation:
                     name:Izmir Katip Celebi University Atatürk Training and Research Hospital
                     address:
                        name:Department of General Surgery, Izmir Katip Celebi University Atatürk Training and Research Hospital, Izmir, Turkey
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:D. Y. Baskiran
               affiliation:
                     name:Inonu University Turgut Ozal Medical Center
                     address:
                        name:Department of Public Health, Faculty of Medicine, Inonu University Turgut Ozal Medical Center, Malatya, Turkey
                        type:PostalAddress
                     type:Organization
               type:Person
               name:S. Akbulut
               affiliation:
                     name:Inonu University Turgut Ozal Medical Center, Institute of Liver Transplantation
                     address:
                        name:Department of General Surgery, Faculty of Medicine, Inonu University Turgut Ozal Medical Center, Institute of Liver Transplantation, Malatya, Turkey
                        type:PostalAddress
                     type:Organization
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Hepatitis B/D-Related Hepatocellular Carcinoma. A Clinical Literature Review
      description:Given the current literature data, this article aims to shed light on the epidemiological and clinical effects of HBV, as well as its impact on the development of hepatocellular carcinoma (HCC). A review of the English language literature based on a MEDLINE (PubMed) database was searched. The keywords were cirrhosis, hepatocellular carcinoma, epidemiology, hepatitis delta virus, hepatitis B virus, and co-infection. All references from retrieved papers were reviewed systematically to find additional collection of reports. The study has broadly confirmed the contribution of HDV viremia to liver disease and cirrhosis. However, uncertainty over the mechanism of action on HCC development remains. As the recent data has demonstrated, the HCC-HDV has a unique molecular profile which is distinct from that of HBV-HCC. Owing to the dependence of HDV on HBV, it is not clear whether HCC is a consequence of the cumulative effect of both HBV and HDV, an effect of the underlying cirrhosis, or a direct oncogenic effect of HDV. Many questions concerning the oncogenic role of HDV remain unanswered. To better understand the role of HDV in carcinogenesis, studies at the molecular level that consider genotype differences should be increased. Multicenter, high-volume, and prospective studies that compare HBV/HDV co-infected and HBV-infected individuals will be pivotal in determining the oncogenic role of HDV.
      datePublished:2021-10-06T00:00:00Z
      dateModified:2021-10-06T00:00:00Z
      pageStart:1192
      pageEnd:1197
      sameAs:https://doi.org/10.1007/s12029-021-00714-x
      keywords:
         Hepatocellular carcinoma
         Cirrhosis
         Hepatitis delta virus
         Hepatitis B virus
         Epidemiology
         Co-infection
         Oncology
         Gastroenterology
         Radiotherapy
         Cancer Research
         Internal Medicine
      image:
      isPartOf:
         name:Journal of Gastrointestinal Cancer
         issn:
            1941-6636
            1941-6628
         volumeNumber:52
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer US
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:A. Baskiran
            affiliation:
                  name:Inonu University Turgut Ozal Medical Center, Institute of Liver Transplantation
                  address:
                     name:Department of General Surgery, Faculty of Medicine, Inonu University Turgut Ozal Medical Center, Institute of Liver Transplantation, Malatya, Turkey
                     type:PostalAddress
                  type:Organization
            type:Person
            name:A. Atay
            url:http://orcid.org/0000-0001-8163-2357
            affiliation:
                  name:Izmir Katip Celebi University Atatürk Training and Research Hospital
                  address:
                     name:Department of General Surgery, Izmir Katip Celebi University Atatürk Training and Research Hospital, Izmir, Turkey
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:D. Y. Baskiran
            affiliation:
                  name:Inonu University Turgut Ozal Medical Center
                  address:
                     name:Department of Public Health, Faculty of Medicine, Inonu University Turgut Ozal Medical Center, Malatya, Turkey
                     type:PostalAddress
                  type:Organization
            type:Person
            name:S. Akbulut
            affiliation:
                  name:Inonu University Turgut Ozal Medical Center, Institute of Liver Transplantation
                  address:
                     name:Department of General Surgery, Faculty of Medicine, Inonu University Turgut Ozal Medical Center, Institute of Liver Transplantation, Malatya, Turkey
                     type:PostalAddress
                  type:Organization
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Journal of Gastrointestinal Cancer
      issn:
         1941-6636
         1941-6628
      volumeNumber:52
Organization:
      name:Springer US
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Inonu University Turgut Ozal Medical Center, Institute of Liver Transplantation
      address:
         name:Department of General Surgery, Faculty of Medicine, Inonu University Turgut Ozal Medical Center, Institute of Liver Transplantation, Malatya, Turkey
         type:PostalAddress
      name:Izmir Katip Celebi University Atatürk Training and Research Hospital
      address:
         name:Department of General Surgery, Izmir Katip Celebi University Atatürk Training and Research Hospital, Izmir, Turkey
         type:PostalAddress
      name:Inonu University Turgut Ozal Medical Center
      address:
         name:Department of Public Health, Faculty of Medicine, Inonu University Turgut Ozal Medical Center, Malatya, Turkey
         type:PostalAddress
      name:Inonu University Turgut Ozal Medical Center, Institute of Liver Transplantation
      address:
         name:Department of General Surgery, Faculty of Medicine, Inonu University Turgut Ozal Medical Center, Institute of Liver Transplantation, Malatya, Turkey
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:A. Baskiran
      affiliation:
            name:Inonu University Turgut Ozal Medical Center, Institute of Liver Transplantation
            address:
               name:Department of General Surgery, Faculty of Medicine, Inonu University Turgut Ozal Medical Center, Institute of Liver Transplantation, Malatya, Turkey
               type:PostalAddress
            type:Organization
      name:A. Atay
      url:http://orcid.org/0000-0001-8163-2357
      affiliation:
            name:Izmir Katip Celebi University Atatürk Training and Research Hospital
            address:
               name:Department of General Surgery, Izmir Katip Celebi University Atatürk Training and Research Hospital, Izmir, Turkey
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:D. Y. Baskiran
      affiliation:
            name:Inonu University Turgut Ozal Medical Center
            address:
               name:Department of Public Health, Faculty of Medicine, Inonu University Turgut Ozal Medical Center, Malatya, Turkey
               type:PostalAddress
            type:Organization
      name:S. Akbulut
      affiliation:
            name:Inonu University Turgut Ozal Medical Center, Institute of Liver Transplantation
            address:
               name:Department of General Surgery, Faculty of Medicine, Inonu University Turgut Ozal Medical Center, Institute of Liver Transplantation, Malatya, Turkey
               type:PostalAddress
            type:Organization
PostalAddress:
      name:Department of General Surgery, Faculty of Medicine, Inonu University Turgut Ozal Medical Center, Institute of Liver Transplantation, Malatya, Turkey
      name:Department of General Surgery, Izmir Katip Celebi University Atatürk Training and Research Hospital, Izmir, Turkey
      name:Department of Public Health, Faculty of Medicine, Inonu University Turgut Ozal Medical Center, Malatya, Turkey
      name:Department of General Surgery, Faculty of Medicine, Inonu University Turgut Ozal Medical Center, Institute of Liver Transplantation, Malatya, Turkey
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(194)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

4.48s.

LINK . SPRINGER . COM {}