We are analyzing https://link.springer.com/article/10.1007/s12026-012-8270-1.

Title:
TLR7 and TLR9 in SLE: when sensing self goes wrong | Immunologic Research
Description:
Autoreactive B and T cells are present in healthy, autoimmunity-free individuals, but they are kept in check by various regulatory mechanisms. In systemic lupus erythematosus (SLE) patients, however, autoreactive cells are expanded, activated, and produce large quantities of autoantibodies, directed especially against nuclear antigens. These antibodies form immune complexes with self-nucleic acids present in SLE serum. Since self-DNA and self-RNA in the form of protein complexes can act as TLR9 and TLR7 ligands, respectively, TLR stimulation is suggested as an additional signal contributing to activation and/or modulation of the aberrant adaptive immune response. Data from mouse models suggest a pathogenic role for TLR7 and a protective role for TLR9 in the pathogenesis of SLE. Future investigations are needed to elucidate the underlying modulatory mechanisms and the role of TLR7 and TLR9 in the complex pathogenesis of human SLE.
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Keywords {🔍}

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Topics {✒️}

granulocyte/macrophage colony-stimulating factor anti-double-stranded dna antibodies month download article/chapter natural ifn-alpha-producing cells cationic lipid-mediated transfection phospholipase c-gamma2 networks autoimmune small-vessel vasculitis cpg motif-independent manner myd88-dependent autoantibody production pathogenic auto-antibody production lupus-related lmb3 locus anti-dna antibodies bind h2a/h2b/dna subnucleosomes louis-dit-sully ca anti-dna antibody production cpg motif-independent activation chromatin-igg complexes activate mucosal b-cell subsets nf-kappab binding affinity santiago-raber ml activated antigen-engaged cells ifn-alpha production induced tlr9-mediated inflammatory responses toll pathway-dependent blockade anti-dsdna autoantibodies prior soluble fas/fasl levels cpg-dna-specific activation slam/cd2 gene cluster full article pdf rna-related antigens due endogenous ifn-alpha inducer tlr7 single-nucleotide polymorphisms case-control association study de la rosa single-stranded rna sequence-specific potent induction lupus nephritis map autoimmune lupus nephritis mrl-lpr/lpr mice privacy choices/manage cookies dna-peptide complexes myd88-dependent pathways induce high amounts plasmacytoid dendritic cells monocyte-derived macrophages gonzalez-gay ma �natural” phosphodiester dna predominant autoantibody production cell-mediated suppression autoimmune glomerulonephritis induced

Questions {❓}

Genetic predisposition to autoimmunity–what have we learned?
Nuclear autoantigen translocation and autoantibody opsonization lead to increased dendritic cell phagocytosis and presentation of nuclear antigens: a novel pathogenic pathway for autoimmunity?
Systemic lupus erythematosus one disease or many?

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