We are analyzing https://link.springer.com/article/10.1007/s12026-007-0084-1.

Title:
Neutrophils and TRAIL: insights into BCG immunotherapy for bladder cancer | Immunologic Research
Description:
Bladder cancer is a huge economic burden on the healthcare system and is responsible for approximately 5% of all cancer deaths in humans. Mycobacterium bovis BCG-based therapy is the treatment of choice for superficial bladder cancer. Bacillus Calmette-Guerin (BCG) instillation in the bladder results in a massive local inflammatory response that has secondary antitumor properties. Recent studies have demonstrated that neutrophils present in the bladder after BCG instillation release large amounts of the apoptosis-inducing molecule TRAIL, as well as chemokines that recruit other immune cells, suggesting that neutrophils play a key role in the antitumor response to BCG therapy. This review discusses the impact of these findings on the understanding of the antitumor mechanisms underlying BCG-based immunotherapy for bladder cancer.
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Keywords {🔍}

google, scholar, article, cancer, trail, ligand, immunol, bladder, cells, cas, bcg, griffith, tumor, apoptosisinducing, human, cell, necrosis, neutrophils, receptor, apoptosis, immunotherapy, bacillus, calmetteguerin, iowa, nauseef, death, factorrelated, exp, med, antitumor, chen, smith, biol, urol, treatment, factor, neutrophil, pubmed, research, thomas, mycobacterium, tnfrelated, res, university, usa, privacy, cookies, content, simons, william,

Topics {✒️}

tnf-related apoptosis-inducing ligand tumour necrosis factor high-resolution x-ray structure tumor necrosis factor month download article/chapter functional soluble trail/apo-2l fas ligand-induced apoptosis apoptosis-inducing molecule trail ifn-gamma-dependent suppression death-inducing signaling complex monocyte-mediated tumoricidal activity lamhamedi-cherradi se bacillus calmette-guerin bladder cancer patients bacille calmette-guerin recombinant apo2l/trail versions bladder tumor cells interferon-activated neutrophils store related subjects de boer ec bladder cancer published superficial bladder cancer degli-esposti ma activation-induced death trail-induced apoptosis trail-mediated apoptosis trail/apo-2 ligand subcutaneous tumor growth defective thymocyte apoptosis full article pdf privacy choices/manage cookies apo2 ligand/trail tumor immune escape apoptosis-mediating receptor cytotoxic ligand trail human neutrophil apoptosis cd4+ t-cell murine bladder mucosa cytotoxicity-dependent apo-1 dendritic cell secretion national cancer institute nk cell-mediated mouse peritoneal macrophages intravesical therapy mucosal cytokine network trail/apo-2l triggering cell death accelerated autoimmune diseases nadph oxidase activation bcg therapy

Questions {❓}

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Schema {🗺️}

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         headline:Neutrophils and TRAIL: insights into BCG immunotherapy for bladder cancer
         description:Bladder cancer is a huge economic burden on the healthcare system and is responsible for approximately 5% of all cancer deaths in humans. Mycobacterium bovis BCG-based therapy is the treatment of choice for superficial bladder cancer. Bacillus Calmette-Guerin (BCG) instillation in the bladder results in a massive local inflammatory response that has secondary antitumor properties. Recent studies have demonstrated that neutrophils present in the bladder after BCG instillation release large amounts of the apoptosis-inducing molecule TRAIL, as well as chemokines that recruit other immune cells, suggesting that neutrophils play a key role in the antitumor response to BCG therapy. This review discusses the impact of these findings on the understanding of the antitumor mechanisms underlying BCG-based immunotherapy for bladder cancer.
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      headline:Neutrophils and TRAIL: insights into BCG immunotherapy for bladder cancer
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