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Title:
Anti-inflammatory Action of Statins in Cardiovascular Disease: the Role of Inflammasome and Toll-Like Receptor Pathways | Clinical Reviews in Allergy & Immunology
Description:
Atherosclerosis is one type of cardiovascular disease (CVD) in which activation of the NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated. One of the most effective treatments for atherosclerosis is the use of statin medications. Recent studies have indicated that statins, in addition to their lipid-lowering effects, exert inhibitory and/or stimulatory effects on the NLRP3 inflammasome and TLRs. Some of the statins lead to activation of the inflammasome and subsequently cause secretion of IL-1β and IL-18. Thus, these actions may further aggravate the disease. On the other hand, some statins cause inhibition of the inflammasome or TLRs and along with lipid-lowering, help to improve the disease by reducing inflammation. In this article, we discuss these contradictory studies and the mechanisms of action of statins on the NLRP3 inflammasome and TLR pathways. The dose-dependent effects of statins on the NLRP3 complex are related to their chemistry, pharmacokinetic properties, and danger signals. Lipophilic statins have more pleiotropic effects on the NLRP3 complex in comparison to hydrophilic statins. Statins can suppress TLR4/MyD88/NF-ĸB signaling and cause an immune response shift to an anti-inflammatory response. Furthermore, statins inhibit the NF-ĸB pathway by decreasing the expression of TLRs 2 and 4. Statins are cost-effective drugs, which should have a continued future in the treatment of atherosclerosis due to both their immune-modulating and lipid-lowering effects.
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Keywords {🔍}
pubmed, google, scholar, cas, atherosclerosis, statins, nlrp, tlr, cells, effects, inflammasome, activation, expression, ilβ, receptor, effect, inflammation, patients, inflammatory, levels, central, atorvastatin, role, signaling, cell, atherosclerotic, shown, studies, nfĸb, tlrs, statin, disease, protein, tolllike, pathway, cholesterol, coronary, study, immune, receptors, oxldl, rosuvastatin, endothelial, leads, mice, antiinflammatory, vascular, caspase, cardiovascular, inhibition,
Topics {✒️}
nuclear factor kappa-light-chain-enhancer suppress tlr4/myd88/nf-ĸb signaling suppressing tlr4/myd88/nf-ĸb pathway tlr4/myd88/nf-ĸb signaling pathway 5 mg/day versus 10 mg/day tlr4/myd88/nf-κb signaling 3-hydroxy-3-methylglutaryl-coa reductase tlr4/myd88/nf-ĸb pathway [137] lps-induced nf-ĸb activation hmg-coa reductase inhibitors 3-hydroxy-3-methyl-glutaryl-coenzyme large-scale randomized study bacteria-derived nucleic acids tumor necrosis factor-α nf-kβ transcription factor abolishing tgf-β signaling hmg-coa reductase inhibitor native low-density lipoprotein lipopolysaccharide–induced cytokine production large-species animal model hyperglycemia-induced endothelial dysfunction statin-induced insulin resistance myd88-deficient mice exhibit tight junction–zonula occludens-1 nf-ĸb transcription factor recombinant mouse tgf-β1 suppress nf-ĸb activity apolipoprotein e-deficient mice oxidized low-density lipoprotein affecting p65 nf-ĸb lps-treated animal models lox1-/nf-ĸb pathway mitogen-activated protein kinases renin–angiotensin system blockade stabilizing nf-ĸb inhibitors multiple host-derived molecules called pattern-recognition receptors activates nf-ĸb pathway decreases nf-ĸb activity lps-induced cytokine production nf-κb-dependent induction mitogen-activated protein kinase randomised placebo-controlled trials zeinab deris zayeri monocyte tlr-signaling network major histocompatibility complex-ii c-reactive protein levels pma-stimulated thp-1 monocytes leucine-rich extracellular region suppressed nf-ĸb activity
Questions {❓}
- Abais JM, Xia M, Zhang Y, Boini KM, Li P-L (2015) Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
- Andreakos E, Foxwell B, Feldmann M (2004) Is targeting Toll-like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine-driven inflammation?
- Arboix A, García-Eroles L, Oliveres M, Targa C, Balcells M, Massons J (2010) Pretreatment with statins improves early outcome in patients with first-ever ischaemic stroke: a pleiotropic effect of statins or a beneficial effect of hypercholesterolemia?
- Bielinska A, Gluszko P (2007) Statins-are they potentially useful in rheumatology?
- Henriksbo BD, Schertzer JD (2015) Is immunity a mechanism contributing to statin-induced diabetes?
- Nelson CP, Erridge C (2019) Are toll-like receptors potential drug targets for atherosclerosis?
- Ridker PM (2013) Closing the loop on inflammation and atherothrombosis: why perform the CIRT and CANTOS trials?
- Sahebkar A, Watts GF (2013) New therapies targeting apoB metabolism for high-risk patients with inherited dyslipidaemias: what can the clinician expect?
- Schönbeck U, Libby P (2004) Inflammation, immunity, and HMG-CoA reductase inhibitors: statins as antiinflammatory agents?
- Yuan C, Zhou L, Cheng J, Zhang J, Teng Y, Huang M et al (2012) Statins as potential therapeutic drug for asthma?
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headline:Anti-inflammatory Action of Statins in Cardiovascular Disease: the Role of Inflammasome and Toll-Like Receptor Pathways
description:Atherosclerosis is one type of cardiovascular disease (CVD) in which activation of the NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated. One of the most effective treatments for atherosclerosis is the use of statin medications. Recent studies have indicated that statins, in addition to their lipid-lowering effects, exert inhibitory and/or stimulatory effects on the NLRP3 inflammasome and TLRs. Some of the statins lead to activation of the inflammasome and subsequently cause secretion of IL-1β and IL-18. Thus, these actions may further aggravate the disease. On the other hand, some statins cause inhibition of the inflammasome or TLRs and along with lipid-lowering, help to improve the disease by reducing inflammation. In this article, we discuss these contradictory studies and the mechanisms of action of statins on the NLRP3 inflammasome and TLR pathways. The dose-dependent effects of statins on the NLRP3 complex are related to their chemistry, pharmacokinetic properties, and danger signals. Lipophilic statins have more pleiotropic effects on the NLRP3 complex in comparison to hydrophilic statins. Statins can suppress TLR4/MyD88/NF-ĸB signaling and cause an immune response shift to an anti-inflammatory response. Furthermore, statins inhibit the NF-ĸB pathway by decreasing the expression of TLRs 2 and 4. Statins are cost-effective drugs, which should have a continued future in the treatment of atherosclerosis due to both their immune-modulating and lipid-lowering effects.
datePublished:2020-05-06T00:00:00Z
dateModified:2020-05-06T00:00:00Z
pageStart:175
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Statins
NLRP3
Inflammasome
TLR4
TLR2
Cardiovascular disease
Atherosclerosis
Allergology
Immunology
Internal Medicine
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headline:Anti-inflammatory Action of Statins in Cardiovascular Disease: the Role of Inflammasome and Toll-Like Receptor Pathways
description:Atherosclerosis is one type of cardiovascular disease (CVD) in which activation of the NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated. One of the most effective treatments for atherosclerosis is the use of statin medications. Recent studies have indicated that statins, in addition to their lipid-lowering effects, exert inhibitory and/or stimulatory effects on the NLRP3 inflammasome and TLRs. Some of the statins lead to activation of the inflammasome and subsequently cause secretion of IL-1β and IL-18. Thus, these actions may further aggravate the disease. On the other hand, some statins cause inhibition of the inflammasome or TLRs and along with lipid-lowering, help to improve the disease by reducing inflammation. In this article, we discuss these contradictory studies and the mechanisms of action of statins on the NLRP3 inflammasome and TLR pathways. The dose-dependent effects of statins on the NLRP3 complex are related to their chemistry, pharmacokinetic properties, and danger signals. Lipophilic statins have more pleiotropic effects on the NLRP3 complex in comparison to hydrophilic statins. Statins can suppress TLR4/MyD88/NF-ĸB signaling and cause an immune response shift to an anti-inflammatory response. Furthermore, statins inhibit the NF-ĸB pathway by decreasing the expression of TLRs 2 and 4. Statins are cost-effective drugs, which should have a continued future in the treatment of atherosclerosis due to both their immune-modulating and lipid-lowering effects.
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Statins
NLRP3
Inflammasome
TLR4
TLR2
Cardiovascular disease
Atherosclerosis
Allergology
Immunology
Internal Medicine
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