We are analyzing https://link.springer.com/article/10.1007/s12016-010-8212-4.

Title:
Macrophagic Myofaciitis a Vaccine (alum) Autoimmune-Related Disease | Clinical Reviews in Allergy & Immunology
Description:
Macrophagic myofasciitis (MMF) is an immune-mediated condition first reported in 1998. MMF is characterized by post-vaccination systemic manifestations as well as local-stereotyped and immunologically active lesion in the site of inoculation (deltoid muscle). MMF systemic symptoms included myalgias, arthralgias, marked asthenia, muscle weakness, chronic fatigue, and fever. Recently, studies demonstrated that the local lesion is due to persistence for years at site of injection of an aluminum (Al(OH)3) adjuvant commonly used in human vaccines. Time elapsed from last immunization with an Al(OH)3-containing vaccine to muscle biopsy range from 3 months to 8 years; in rare cases, MMF may be diagnosed even 10 years post-vaccination. The discrepancy between the wide applications of aluminum hydroxide-containing vaccines and the very limited number of MMF cases reported may be resolved by observations suggesting that aluminum-containing vaccinations may trigger MMF in genetically susceptible subjects carrying the HLA-DRB1*01. Thus, MMF may be defined as an emerging novel condition that may be triggered by exposure to alum-containing vaccines, in patients with a specific genetic background, and this temporal association may be exhibited from a few months up to 10 years.
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Keywords {🔍}

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Topics {✒️}

autoimmune-related disease published month download article/chapter vaccine adjuvant-related syndrome autoimmune-related disease laura schwarz-kip chair post-vaccination systemic manifestations article clinical reviews gherardi rk vaccine-derived aluminium hydroxide human macrophages full article pdf nancy agmon-levin privacy choices/manage cookies related subjects yehuda shoenfeld macrophagic myofasciitis unrelated sheba medical center article israeli european economic area subcutaneous pseudolymphoma caused multi-symptom conditions gulf war veterans inducing uric acid aluminic vaccine adjuvants macrophagic myofaciitis 10 years post-vaccination conditions privacy policy immunologically active lesion authier fj chronic fatigue syndrome immune-mediated condition check access instant access adjuvant commonly accepting optional cookies muscle biopsy range authors declare specific genetic background article log tel-aviv university recently identified condition journal finder publish author correspondence aluminum hydroxide agmon-levin article cite macrophagic myofasciitis mmf cases reported park yw aluminum phagocytosis

Questions {❓}

Guis S, Mattei JP, Nicoli F et al (2002) Identical twins with macrophagic myofasciitis: genetic susceptibility and triggering by aluminic vaccine adjuvants?

Schema {🗺️}

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         description:Macrophagic myofasciitis (MMF) is an immune-mediated condition first reported in 1998. MMF is characterized by post-vaccination systemic manifestations as well as local-stereotyped and immunologically active lesion in the site of inoculation (deltoid muscle). MMF systemic symptoms included myalgias, arthralgias, marked asthenia, muscle weakness, chronic fatigue, and fever. Recently, studies demonstrated that the local lesion is due to persistence for years at site of injection of an aluminum (Al(OH)3) adjuvant commonly used in human vaccines. Time elapsed from last immunization with an Al(OH)3-containing vaccine to muscle biopsy range from 3 months to 8 years; in rare cases, MMF may be diagnosed even 10 years post-vaccination. The discrepancy between the wide applications of aluminum hydroxide-containing vaccines and the very limited number of MMF cases reported may be resolved by observations suggesting that aluminum-containing vaccinations may trigger MMF in genetically susceptible subjects carrying the HLA-DRB1*01. Thus, MMF may be defined as an emerging novel condition that may be triggered by exposure to alum-containing vaccines, in patients with a specific genetic background, and this temporal association may be exhibited from a few months up to 10 years.
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      headline:Macrophagic Myofaciitis a Vaccine (alum) Autoimmune-Related Disease
      description:Macrophagic myofasciitis (MMF) is an immune-mediated condition first reported in 1998. MMF is characterized by post-vaccination systemic manifestations as well as local-stereotyped and immunologically active lesion in the site of inoculation (deltoid muscle). MMF systemic symptoms included myalgias, arthralgias, marked asthenia, muscle weakness, chronic fatigue, and fever. Recently, studies demonstrated that the local lesion is due to persistence for years at site of injection of an aluminum (Al(OH)3) adjuvant commonly used in human vaccines. Time elapsed from last immunization with an Al(OH)3-containing vaccine to muscle biopsy range from 3 months to 8 years; in rare cases, MMF may be diagnosed even 10 years post-vaccination. The discrepancy between the wide applications of aluminum hydroxide-containing vaccines and the very limited number of MMF cases reported may be resolved by observations suggesting that aluminum-containing vaccinations may trigger MMF in genetically susceptible subjects carrying the HLA-DRB1*01. Thus, MMF may be defined as an emerging novel condition that may be triggered by exposure to alum-containing vaccines, in patients with a specific genetic background, and this temporal association may be exhibited from a few months up to 10 years.
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         Autoimmunity
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