We are analyzing https://link.springer.com/article/10.1007/s12015-025-10917-5.

Title:
Age-Related Macular Degeneration: Therapeutic Strategies Based on Stem Cells | Stem Cell Reviews and Reports
Description:
Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss among the elderly in developed countries, manifesting in two primary forms: neovascular (wet) AMD and non-neovascular (dry) AMD. Current treatments, such as anti-VEGF therapy, offer limited efficacy, particularly for dry AMD, highlighting the urgent need for alternative strategies. Advancements in contemporary treatment strategies for these eye conditions are a pressing medical concern. Stem cell-based therapies have emerged as a promising approach for retinal regeneration due to their capacity for self-renewal and differentiation into retinal cell types, including retinal pigment epithelial (RPE) cells and photoreceptors, two key cell populations damaged in AMD. Among the various sources, pluripotent stem cells such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) show significant potential in generating functional RPE cells and restoring retinal architecture and function. Preclinical and early clinical studies have demonstrated promising outcomes, including improved visual acuity and anatomical integration. However, challenges such as immune rejection, tumorigenicity, limited long-term integration, and ethical concerns continue to impede clinical translation. This review critically evaluates current stem cell-based therapeutic strategies for AMD, including advances in mesenchymal stem cells, retinal organoids, and combinatorial approaches with gene and nanotherapy. Furthermore, this review outlines the translational bottlenecks and future directions required to advance these therapies toward clinical application. Graphical Abstract
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

pubmed, article, stem, google, scholar, cells, cas, retinal, cell, degeneration, macular, central, human, pluripotent, journal, agerelated, pigment, research, therapy, induced, ophthalmology, epithelium, medicine, nature, transplantation, clinical, epithelial, mesenchymal, httpsdoiorgs, embryonic, httpsdoiorg, zhang, takahashi, therapeutic, rpe, therapies, science, cellderived, experimental, bone, amd, eye, differentiation, potential, review, adult, biology, diseases, model, university,

Topics {✒️}

bone marrow-derived cell cell replacement therapy age-related macular degeneration stem/progenitor cell-based transplantation clinical trials photoreceptor cell replacement stem cell-based therapies retinal pigment epithelium hipsc-derived rpe cells month download article/chapter 75c5tissue-specific stem cells mesenchymal stem cells patient-derived organoids pluripotent stem cells retinal pigmented epithelium derived retinal cells hematopoietic stem cells stem cell therapy stem cells therapy cell stem cell organizing optic-cup morphogenesis biores open access low-dose recombinant adeno marrow stromal cells autologous “stem cells” stem cell therapies adult frogs derived org/article/view/61730 weiss retinal organoids adult neural stem stem cell research stem cell reports tissue repair–current views stem cells dev 2022 cell-based therapies adult mammalian cells stem cell niche stem cell rev inherited macular degeneration cells-based therapies adult human fibroblasts intestinal stem cells stem cells int retinal cell types single somatic cells epithelial cells driven retinal ganglion cells ips cell modeling stem cells published human somatic cells

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      description:Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss among the elderly in developed countries, manifesting in two primary forms: neovascular (wet) AMD and non-neovascular (dry) AMD. Current treatments, such as anti-VEGF therapy, offer limited efficacy, particularly for dry AMD, highlighting the urgent need for alternative strategies. Advancements in contemporary treatment strategies for these eye conditions are a pressing medical concern. Stem cell-based therapies have emerged as a promising approach for retinal regeneration due to their capacity for self-renewal and differentiation into retinal cell types, including retinal pigment epithelial (RPE) cells and photoreceptors, two key cell populations damaged in AMD. Among the various sources, pluripotent stem cells such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) show significant potential in generating functional RPE cells and restoring retinal architecture and function. Preclinical and early clinical studies have demonstrated promising outcomes, including improved visual acuity and anatomical integration. However, challenges such as immune rejection, tumorigenicity, limited long-term integration, and ethical concerns continue to impede clinical translation. This review critically evaluates current stem cell-based therapeutic strategies for AMD, including advances in mesenchymal stem cells, retinal organoids, and combinatorial approaches with gene and nanotherapy. Furthermore, this review outlines the translational bottlenecks and future directions required to advance these therapies toward clinical application.
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