We are analyzing https://link.springer.com/article/10.1007/s12015-024-10710-w.

Title:
A Senescence-Associated Secretory Phenotype of Bone Marrow Mesenchymal Stem Cells Inhibits the Viability of Breast Cancer Cells | Stem Cell Reviews and Reports
Description:
Breast cancer, the most prevalent malignancy in women, often progresses to bone metastases, especially in older individuals. Dormancy, a critical aspect of bone-metastasized breast cancer cells (BCCs), enables them to evade treatment and recur. This dormant state is regulated by bone marrow mesenchymal stem cells (BMMSCs) through the secretion of various factors, including those associated with senescence. However, the specific mechanisms by which BMMSCs induce dormancy in BCCs remain unclear. To address this gap, a bone-specific senescence-accelerated murine model, SAMP6, was utilized to minimize confounding systemic age-related factors. Confirming senescence-accelerated osteoporosis, distinct BMMSC phenotypes were observed in SAMP6 mice compared to SAMR1 counterparts. Notably, SAMP6-BMMSCs exhibited premature senescence primarily due to telomerase activity loss and activation of the p21 signaling pathway. Furthermore, the effects of conditioned medium (CM) derived from SAMP6-BMMSCs versus SAMR1-BMMSCs on BCC proliferation were examined. Intriguingly, only CM from SAMP6-BMMSCs inhibited BCC proliferation by upregulating p21 expression in both MCF-7 and MDA-MB-231 cells. These findings suggest that the senescence-associated secretory phenotype (SASP) of BMMSCs suppresses BCC viability by inducing p21, a pivotal cell cycle inhibitor and tumor suppressor. This highlights a heightened susceptibility of BCCs to dormancy in a senescent microenvironment, potentially contributing to the increased incidence of breast cancer bone metastasis and recurrence observed with aging. Graphical Abstract
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Keywords {🔍}

pubmed, article, google, scholar, cas, cells, stem, cancer, bone, cell, research, mesenchymal, breast, central, oral, journal, nature, shaanxi, metastasis, clinical, center, marrow, dormancy, diseases, medical, state, china, key, laboratory, military, liu, niche, university, senescence, national, cxz, hkx, fourth, xian, data, reviews, stomatology, author, maxillofacial, privacy, cookies, content, consent, senescenceassociated, secretory,

Topics {✒️}

month download article/chapter adipose-derived stromal cells samp6-bmmscs versus samr1-bmmscs adult bone marrow haematopoietic stem-cell maintenance hao-kun xu mesenchymal stem cells confirming senescence-accelerated osteoporosis vegf-nrp1 loop regulate state key laboratory mda-mb-231 cells chen-xi zheng cheng-hu hu writing—original draft preparation tgf-beta/mirna axis cancer stem cells site-specific bone loss cell stem cell age-related disease tumor stroma formation bone-marrow-derived breast cancer cells stem cell rev targeted-gene delivery vehicles full article pdf prostate cancer stem bmmscs induce dormancy human breast cancer host-related factors rui hou osteoblastic cells regulate senescence-accelerated mouse beta2-adrenergic receptor early mesenchymal progenitors circulating tumor cells breast cancer research related subjects mammary carcinoma clinical cancer research ovariectomy-induced osteoporosis samp6 mice compared mesenchymal cells age-related privacy choices/manage cookies osteolytic bone metastases cellular senescence telomerase activity loss physiologic culture approaches osteoporosis bone marrow article li

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               name:State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, National Clinical Research Center for Oral Diseases, The Fourth Military Medical University, Xi’an, China
               type:PostalAddress
            type:Organization
      name:Ji Chen
      affiliation:
            name:National Clinical Research Center for Oral Diseases, The Fourth Military Medical University
            address:
               name:State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, National Clinical Research Center for Oral Diseases, The Fourth Military Medical University, Xi’an, China
               type:PostalAddress
            type:Organization
            name:National Clinical Research Center for Oral Diseases, The Fourth Military Medical University
            address:
               name:State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral Implantology, School of Stomatology, National Clinical Research Center for Oral Diseases, The Fourth Military Medical University, Xi’an, China
               type:PostalAddress
            type:Organization
      name:Fang Jin
      affiliation:
            name:National Clinical Research Center for Oral Diseases, The Fourth Military Medical University
            address:
               name:State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, National Clinical Research Center for Oral Diseases, The Fourth Military Medical University, Xi’an, China
               type:PostalAddress
            type:Organization
            name:National Clinical Research Center for Oral Diseases, The Fourth Military Medical University
            address:
               name:State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Shaanxi Clinical Research Center for Oral Diseases, Department of Orthodontics, School of Stomatology, National Clinical Research Center for Oral Diseases, The Fourth Military Medical University, Xi’an, China
               type:PostalAddress
            type:Organization
      name:Cheng-Hu Hu
      affiliation:
            name:Northwestern Polytechnical University
            address:
               name:Xi’an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, Xi’an, China
               type:PostalAddress
            type:Organization
      name:Hao-Kun Xu
      affiliation:
            name:National Clinical Research Center for Oral Diseases, The Fourth Military Medical University
            address:
               name:State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, National Clinical Research Center for Oral Diseases, The Fourth Military Medical University, Xi’an, China
               type:PostalAddress
            type:Organization
            name:National Clinical Research Center for Oral Diseases, The Fourth Military Medical University
            address:
               name:State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, National Clinical Research Center for Oral Diseases, The Fourth Military Medical University, Xi’an, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Chen-Xi Zheng
      url:http://orcid.org/0000-0001-9129-892X
      affiliation:
            name:National Clinical Research Center for Oral Diseases, The Fourth Military Medical University
            address:
               name:State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, National Clinical Research Center for Oral Diseases, The Fourth Military Medical University, Xi’an, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Rui Hou
      affiliation:
            name:National Clinical Research Center for Oral Diseases, The Fourth Military Medical University
            address:
               name:State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, National Clinical Research Center for Oral Diseases, The Fourth Military Medical University, Xi’an, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Shaanxi Clinical Research Center for Oral Diseases, Department of Prosthodontics, School of Stomatology, National Clinical Research Center for Oral Diseases, The Fourth Military Medical University, Xi’an, China
      name:State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, National Clinical Research Center for Oral Diseases, The Fourth Military Medical University, Xi’an, China
      name:State Key Laboratory of Toxicology and Medical Countermeasures, Laboratory of Toxicant Analysis, Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, China
      name:State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, National Clinical Research Center for Oral Diseases, The Fourth Military Medical University, Xi’an, China
      name:State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, National Clinical Research Center for Oral Diseases, The Fourth Military Medical University, Xi’an, China
      name:State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral Implantology, School of Stomatology, National Clinical Research Center for Oral Diseases, The Fourth Military Medical University, Xi’an, China
      name:State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, National Clinical Research Center for Oral Diseases, The Fourth Military Medical University, Xi’an, China
      name:State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Shaanxi Clinical Research Center for Oral Diseases, Department of Orthodontics, School of Stomatology, National Clinical Research Center for Oral Diseases, The Fourth Military Medical University, Xi’an, China
      name:Xi’an Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Research, Northwestern Polytechnical University, Xi’an, China
      name:State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, National Clinical Research Center for Oral Diseases, The Fourth Military Medical University, Xi’an, China
      name:State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, National Clinical Research Center for Oral Diseases, The Fourth Military Medical University, Xi’an, China
      name:State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, National Clinical Research Center for Oral Diseases, The Fourth Military Medical University, Xi’an, China
      name:State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, National Clinical Research Center for Oral Diseases, The Fourth Military Medical University, Xi’an, China
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