We are analyzing https://link.springer.com/article/10.1007/s12015-010-9208-4.

Title:
The Role of Human Aldehyde Dehydrogenase in Normal and Cancer Stem Cells | Stem Cell Reviews and Reports
Description:
Normal stem cells and cancer stem cells (CSCs) share similar properties, in that both have the capacity to self-renew and differentiate into multiple cell types. In both the normal stem cell and cancer stem cell fields, there has been a great need for a universal marker that can effectively identify and isolate these rare populations of cells in order to characterize them and use this information for research and therapeutic purposes. Currently, it would appear that certain isoenzymes of the aldehyde dehydrogenase (ALDH) superfamily may be able to fulfill this role as a marker for both normal and cancer stem cells. ALDH has been identified as an important enzyme in the protection of normal hematopoietic stem cells, and is now also widely used as a marker to identify and isolate various types of normal stem cells and CSCs. In addition, emerging evidence suggests that ALDH1 is not only a marker for stem cells, but may also play important functional roles related to self-protection, differentiation, and expansion. This comprehensive review discusses the role that ALDH plays in normal stem cells and CSCs, with focus on ALDH1 and ALDH3A1. Discrepancies in the functional themes between cell types and future perspectives for therapeutic applications will also be discussed.
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Topics {✒️}

ccaat/enhancer-binding protein beta major retinoic-acid-synthesizing enzyme primitive haematopoietic cells human colon-cancer-initiating cells stem/progenitor cell properties small-cell lung cancer anti-apoptotic protein bcl-2 malignant cancer-initiating cells tumor necrosis factor spg21 protein acp33/maspardin month download article/chapter bone marrow cells htert-immortalized primary nonmalignant retinoid signaling induces aldehyde dehydrogenase class-1a1 cell stem cell initiating tumor growth aldehyde-dehydrogenase gene transfer cd34+cd38-cd19+ cells hematopoietic repopulating cells pyridoxine-dependent epilepsy cancer stem cells cancer stem cell heart rate variability high aldehyde dehydrogenase tumor initiating cells tumor-initiating cells hematopoietic progenitor cells trans-retinoic acid trans retinoic acid normal stem cells stem cell rev regulates aldehyde dehydrogenase normal stem cell human epithelial cancers human progenitor cells negative estrogen receptor breast cancer cells enhanced aggressive properties human prostate cancer metastasis-initiating cells stem cell marker aldehyde dehydrogenase activity stem cell function high ki67 expression tumour-initiating cells cyclophosphamide-resistant l1210 leukemia murine hematopoietic progenitors cancer chemotherapeutic regimens human aldehyde dehydrogenase

Questions {❓}

If cancer stem cells are resistant to current therapies, what’s next?

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         description:Normal stem cells and cancer stem cells (CSCs) share similar properties, in that both have the capacity to self-renew and differentiate into multiple cell types. In both the normal stem cell and cancer stem cell fields, there has been a great need for a universal marker that can effectively identify and isolate these rare populations of cells in order to characterize them and use this information for research and therapeutic purposes. Currently, it would appear that certain isoenzymes of the aldehyde dehydrogenase (ALDH) superfamily may be able to fulfill this role as a marker for both normal and cancer stem cells. ALDH has been identified as an important enzyme in the protection of normal hematopoietic stem cells, and is now also widely used as a marker to identify and isolate various types of normal stem cells and CSCs. In addition, emerging evidence suggests that ALDH1 is not only a marker for stem cells, but may also play important functional roles related to self-protection, differentiation, and expansion. This comprehensive review discusses the role that ALDH plays in normal stem cells and CSCs, with focus on ALDH1 and ALDH3A1. Discrepancies in the functional themes between cell types and future perspectives for therapeutic applications will also be discussed.
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