We are analyzing https://link.springer.com/article/10.1007/s11999-008-0243-2.

Title:
Attenuated Salmonella typhimurium with IL-2 Gene Reduces Pulmonary Metastases in Murine Osteosarcoma | Clinical Orthopaedics and Related Research®
Description:
Historically, osteosarcoma has been a problematic metastatic disease, with 40–80% of patients developing pulmonary metastasis after primary tumor resection. Recent treatment advancements have reduced the occurrence of metastatic lesions to less than 30%. Using attenuated Salmonella typhimurium, we previously demonstrated regression in tumor burden in murine solid tumor and metastatic models. We established a murine model for metastatic osteosarcoma to determine the effect of treatment with a single oral dose of attenuated S. typhimurium with (SalpIL2) and without (Sal-NG) a gene for a truncated human interleukin-2. Female balb/c mice were administered 2 × 105 (ATCC K7M2) osteosarcoma cells via tail vein injection from culture and treated by oral gavage of Salmonella species 3 days later. Mice were harvested for splenic lymphocytes and tumor enumeration by intratracheal injection with India ink 21 days after injection. Treatment with attenuated SalpIL2 reduced pulmonary metastases in number and volume compared to saline controls. Furthermore, splenic natural killer cell populations were increased 93% with SalpIL2 and 114% with Sal-NG compared to nontreated groups. This pulmonary metastasis model demonstrates attenuated Salmonella typhimurium with human interleukin-2 reduced metastatic osteosarcoma in mice and confirm the need for further investigation into the immunologic properties of SalpIL2 as a possible treatment for metastatic osteosarcoma.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
However, some sources were not loaded, we suggest to reload the page to get complete results.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don’t know how the website earns money.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Link.springer.com might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

article, google, scholar, pubmed, cas, salmonella, cancer, typhimurium, osteosarcoma, attenuated, interleukin, leonard, saltzman, gene, tumor, metastatic, surg, pulmonary, metastases, murine, research, treatment, sorenson, access, bone, antitumor, clin, privacy, cookies, content, related, phd, patients, model, human, pediatr, curtiss, kelly, pediatric, oncol, author, information, publish, search, metastasis, reduced, oral, salpil, splenic, agent,

Topics {✒️}

month download article/chapter liposome-dna complexes encoding article clinical orthopaedics therapeutic cancer vaccines pulmonary metastases identification high-dose therapy clin exp metastasis soto lj 3rd bone joint surg primary bone osteosarcoma full article pdf attenuated salmonella typhimurium privacy choices/manage cookies tumor-targeted salmonella pulmonary metastatic potential related research brent unresectable hepatic metastases attenuated salmonella engineered cancer gene ther osteosarcoma lung metastases salmonella vaccine strain hum gene ther breast cancer vaccine anaerobic salmonella typhimurium oral salmonella typhimurium vivo antigen delivery pulmonary metastases feltis ba solis sj rosenberg sa truncated human interleukin-2 high level expression decreases tumor burden high-dose interleukin-2 salmonella species 3 days saline controls cyclooxygenase-2 inhibition augments high-dose methotrexate adenovector-mediated delivery cancer treat rev cancer biother radiopharm national cancer institute single oral dose anti-tumor agent european economic area selected papers presented previously demonstrated regression india ink 21 days dis colon rectum minnesota cancer center

Questions {❓}

Antitumor mechanisms of attenuated salmonella typhimurium containing the gene for human interleukin-2: a novel antitumor agent?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Attenuated Salmonella typhimurium with IL-2 Gene Reduces Pulmonary Metastases in Murine Osteosarcoma
         description:Historically, osteosarcoma has been a problematic metastatic disease, with 40–80% of patients developing pulmonary metastasis after primary tumor resection. Recent treatment advancements have reduced the occurrence of metastatic lesions to less than 30%. Using attenuated Salmonella typhimurium, we previously demonstrated regression in tumor burden in murine solid tumor and metastatic models. We established a murine model for metastatic osteosarcoma to determine the effect of treatment with a single oral dose of attenuated S. typhimurium with (SalpIL2) and without (Sal-NG) a gene for a truncated human interleukin-2. Female balb/c mice were administered 2 × 105 (ATCC K7M2) osteosarcoma cells via tail vein injection from culture and treated by oral gavage of Salmonella species 3 days later. Mice were harvested for splenic lymphocytes and tumor enumeration by intratracheal injection with India ink 21 days after injection. Treatment with attenuated SalpIL2 reduced pulmonary metastases in number and volume compared to saline controls. Furthermore, splenic natural killer cell populations were increased 93% with SalpIL2 and 114% with Sal-NG compared to nontreated groups. This pulmonary metastasis model demonstrates attenuated Salmonella typhimurium with human interleukin-2 reduced metastatic osteosarcoma in mice and confirm the need for further investigation into the immunologic properties of SalpIL2 as a possible treatment for metastatic osteosarcoma.
         datePublished:2008-04-18T00:00:00Z
         dateModified:2008-04-18T00:00:00Z
         pageStart:1285
         pageEnd:1291
         sameAs:https://doi.org/10.1007/s11999-008-0243-2
         keywords:
            Osteosarcoma
            Pulmonary Metastasis
            Saline Control
            Splenic Lymphocyte
            Capillary Leak Syndrome
            Orthopedics
            Surgical Orthopedics
            Medicine/Public Health
            general
            Surgery
            Sports Medicine
            Conservative Orthopedics
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11999-008-0243-2/MediaObjects/11999_2008_243_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11999-008-0243-2/MediaObjects/11999_2008_243_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11999-008-0243-2/MediaObjects/11999_2008_243_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11999-008-0243-2/MediaObjects/11999_2008_243_Fig4_HTML.jpg
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11999-008-0243-2/MediaObjects/11999_2008_243_Fig5_HTML.jpg
         isPartOf:
            name:Clinical Orthopaedics and Related Research
            issn:
               1528-1132
               0009-921X
            volumeNumber:466
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer-Verlag
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Brent S. Sorenson
               affiliation:
                     name:University of Minnesota Medical School
                     address:
                        name:Department of Surgery, University of Minnesota Medical School, Minneapolis, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Kaysie L. Banton
               affiliation:
                     name:University of Minnesota Medical School
                     address:
                        name:Department of Surgery, University of Minnesota Medical School, Minneapolis, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Natalie L. Frykman
               affiliation:
                     name:University of Minnesota Medical School
                     address:
                        name:Department of Surgery, University of Minnesota Medical School, Minneapolis, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Arnold S. Leonard
               affiliation:
                     name:University of Minnesota Medical School
                     address:
                        name:Department of Surgery, University of Minnesota Medical School, Minneapolis, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Daniel A. Saltzman
               affiliation:
                     name:University of Minnesota Medical School
                     address:
                        name:Department of Surgery, University of Minnesota Medical School, Minneapolis, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Attenuated Salmonella typhimurium with IL-2 Gene Reduces Pulmonary Metastases in Murine Osteosarcoma
      description:Historically, osteosarcoma has been a problematic metastatic disease, with 40–80% of patients developing pulmonary metastasis after primary tumor resection. Recent treatment advancements have reduced the occurrence of metastatic lesions to less than 30%. Using attenuated Salmonella typhimurium, we previously demonstrated regression in tumor burden in murine solid tumor and metastatic models. We established a murine model for metastatic osteosarcoma to determine the effect of treatment with a single oral dose of attenuated S. typhimurium with (SalpIL2) and without (Sal-NG) a gene for a truncated human interleukin-2. Female balb/c mice were administered 2 × 105 (ATCC K7M2) osteosarcoma cells via tail vein injection from culture and treated by oral gavage of Salmonella species 3 days later. Mice were harvested for splenic lymphocytes and tumor enumeration by intratracheal injection with India ink 21 days after injection. Treatment with attenuated SalpIL2 reduced pulmonary metastases in number and volume compared to saline controls. Furthermore, splenic natural killer cell populations were increased 93% with SalpIL2 and 114% with Sal-NG compared to nontreated groups. This pulmonary metastasis model demonstrates attenuated Salmonella typhimurium with human interleukin-2 reduced metastatic osteosarcoma in mice and confirm the need for further investigation into the immunologic properties of SalpIL2 as a possible treatment for metastatic osteosarcoma.
      datePublished:2008-04-18T00:00:00Z
      dateModified:2008-04-18T00:00:00Z
      pageStart:1285
      pageEnd:1291
      sameAs:https://doi.org/10.1007/s11999-008-0243-2
      keywords:
         Osteosarcoma
         Pulmonary Metastasis
         Saline Control
         Splenic Lymphocyte
         Capillary Leak Syndrome
         Orthopedics
         Surgical Orthopedics
         Medicine/Public Health
         general
         Surgery
         Sports Medicine
         Conservative Orthopedics
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11999-008-0243-2/MediaObjects/11999_2008_243_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11999-008-0243-2/MediaObjects/11999_2008_243_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11999-008-0243-2/MediaObjects/11999_2008_243_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11999-008-0243-2/MediaObjects/11999_2008_243_Fig4_HTML.jpg
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11999-008-0243-2/MediaObjects/11999_2008_243_Fig5_HTML.jpg
      isPartOf:
         name:Clinical Orthopaedics and Related Research
         issn:
            1528-1132
            0009-921X
         volumeNumber:466
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer-Verlag
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Brent S. Sorenson
            affiliation:
                  name:University of Minnesota Medical School
                  address:
                     name:Department of Surgery, University of Minnesota Medical School, Minneapolis, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Kaysie L. Banton
            affiliation:
                  name:University of Minnesota Medical School
                  address:
                     name:Department of Surgery, University of Minnesota Medical School, Minneapolis, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Natalie L. Frykman
            affiliation:
                  name:University of Minnesota Medical School
                  address:
                     name:Department of Surgery, University of Minnesota Medical School, Minneapolis, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Arnold S. Leonard
            affiliation:
                  name:University of Minnesota Medical School
                  address:
                     name:Department of Surgery, University of Minnesota Medical School, Minneapolis, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Daniel A. Saltzman
            affiliation:
                  name:University of Minnesota Medical School
                  address:
                     name:Department of Surgery, University of Minnesota Medical School, Minneapolis, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:Clinical Orthopaedics and Related Research
      issn:
         1528-1132
         0009-921X
      volumeNumber:466
Organization:
      name:Springer-Verlag
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:University of Minnesota Medical School
      address:
         name:Department of Surgery, University of Minnesota Medical School, Minneapolis, USA
         type:PostalAddress
      name:University of Minnesota Medical School
      address:
         name:Department of Surgery, University of Minnesota Medical School, Minneapolis, USA
         type:PostalAddress
      name:University of Minnesota Medical School
      address:
         name:Department of Surgery, University of Minnesota Medical School, Minneapolis, USA
         type:PostalAddress
      name:University of Minnesota Medical School
      address:
         name:Department of Surgery, University of Minnesota Medical School, Minneapolis, USA
         type:PostalAddress
      name:University of Minnesota Medical School
      address:
         name:Department of Surgery, University of Minnesota Medical School, Minneapolis, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Brent S. Sorenson
      affiliation:
            name:University of Minnesota Medical School
            address:
               name:Department of Surgery, University of Minnesota Medical School, Minneapolis, USA
               type:PostalAddress
            type:Organization
      name:Kaysie L. Banton
      affiliation:
            name:University of Minnesota Medical School
            address:
               name:Department of Surgery, University of Minnesota Medical School, Minneapolis, USA
               type:PostalAddress
            type:Organization
      name:Natalie L. Frykman
      affiliation:
            name:University of Minnesota Medical School
            address:
               name:Department of Surgery, University of Minnesota Medical School, Minneapolis, USA
               type:PostalAddress
            type:Organization
      name:Arnold S. Leonard
      affiliation:
            name:University of Minnesota Medical School
            address:
               name:Department of Surgery, University of Minnesota Medical School, Minneapolis, USA
               type:PostalAddress
            type:Organization
      name:Daniel A. Saltzman
      affiliation:
            name:University of Minnesota Medical School
            address:
               name:Department of Surgery, University of Minnesota Medical School, Minneapolis, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Surgery, University of Minnesota Medical School, Minneapolis, USA
      name:Department of Surgery, University of Minnesota Medical School, Minneapolis, USA
      name:Department of Surgery, University of Minnesota Medical School, Minneapolis, USA
      name:Department of Surgery, University of Minnesota Medical School, Minneapolis, USA
      name:Department of Surgery, University of Minnesota Medical School, Minneapolis, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(134)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

4.5s.

LINK . SPRINGER . COM {}