We are analyzing https://link.springer.com/article/10.1007/s11926-007-0008-z.

Title:
New developments in fibroblast and myofibroblast biology: Implications for fibrosis and scleroderma | Current Rheumatology Reports
Description:
The concept of mesenchymal fibroblasts has evolved over the past two decades from a relatively inert structural cell type to a dynamic, pluripotent cell lineage controlling normal connective tissue formation, homeostasis, and repair and as principle players in pathogenic scarring and fibrosis. In wound healing and tissue repair, fibroblasts provide proinflammatory signals and synthesize interstitial collagens, fibronectins, and other matrix components to repair the damaged tissue. Fibroblasts can differentiate into the myofibroblast, a specialized contractile cell type responsible for wound closure, tissue contraction, and scarring. This article reviews our current understanding of the origins of mesenchymal cells and their role in excessive scarring and fibrogenesis and in the systemic fibrotic disease scleroderma.
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Keywords {🔍}

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Topics {✒️}

rac/phosphoinositide 3-kinase/akt-dependent pathway platelet-derived growth factor transforming growth factor-beta1 month download article/chapter bone marrow-derived cells diminishes tgf-beta production connective tissue remodelling connective tissue remodeling stem cell factor mesenchymal stem cells pluripotent stem cells tissue engineering references monocyte chemoattractant protein-1 tgf-beta signaling full article pdf terminal cell lineage epithelial-mesenchymal transition epithelial-mesenchymal transformation marrow stromal cells enhanced myofibroblastic differentiation normal tissue repair human dermal fibroblasts privacy choices/manage cookies gene expression signature bochaton-piallat ml tgf-beta1 production vineeth rajkumar msc alveolar epithelial cells mesenchymal cells related subjects endogenous il-1alpha elevated serum levels il-6-deficient mice enhanced contractile phenotype shi-wen human skin fibroblasts il-13alpha2 receptor collagen-secreting cells collagen-producing cells tight-skin mutation cutaneous scleroderma fibroblasts endothelin receptor antagonists keratinocyte-fibroblast cocultures european economic area synthesize interstitial collagens fibronectin domain ed postlethwaite ae peripheral blood excessive dermal scarring university college london

Questions {❓}

Korn JH: What’s wrong with the scleroderma fibroblast?

Schema {🗺️}

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         description:The concept of mesenchymal fibroblasts has evolved over the past two decades from a relatively inert structural cell type to a dynamic, pluripotent cell lineage controlling normal connective tissue formation, homeostasis, and repair and as principle players in pathogenic scarring and fibrosis. In wound healing and tissue repair, fibroblasts provide proinflammatory signals and synthesize interstitial collagens, fibronectins, and other matrix components to repair the damaged tissue. Fibroblasts can differentiate into the myofibroblast, a specialized contractile cell type responsible for wound closure, tissue contraction, and scarring. This article reviews our current understanding of the origins of mesenchymal cells and their role in excessive scarring and fibrogenesis and in the systemic fibrotic disease scleroderma.
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