We are analyzing https://link.springer.com/article/10.1007/s11912-020-00969-w.

Title:
Striving toward Improved Outcomes for Surgically Resectable Non-Small Cell Lung Cancer: the Promise and Challenges of Neoadjuvant Immunotherapy | Current Oncology Reports
Description:
Purpose of Review Immunotherapy has revolutionized the treatment of non-surgical stage III and stage IV non-small cell lung cancer (NSCLC). Here, we review emerging data on the safety, feasibility, and efficacy of neoadjuvant immunotherapy in the setting of earlier stage surgically resectable lung cancer. Recent Findings Several small studies support the safety and feasibility of neoadjuvant immunotherapy, noting similar perioperative rates of morbidity and mortality compared with historical controls. Data from several phase II trials have shown high rates of major pathologic response (MPR), though it is unclear if this will correlate with a survival benefit. Phase III trials of neoadjuvant immunotherapy alone or in combination with chemotherapy are ongoing. Summary Neoadjuvant immunotherapy offers a promising treatment modality in earlier stage NSCLC patients. Results of ongoing phase II and phase III trials will be essential in determining how to best integrate this treatment modality in the future.
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Keywords {🔍}

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Topics {✒️}

month download article/chapter org/professionals/physician_gls/pdf/nscl small-cell lung carcinoma small-cell lung cancer small-cell lung cancer immune-related response criteria small-cell lung cancers early-stage lung cancer major pathologic response gov/statfacts/html/lungb post-operative adjuvant chemotherapy lung cancer access full article pdf cisplatin-based adjuvant chemotherapy lace collaborative group revised recist guideline major pathological response surgery versus surgery received research funding national cancer institute pd-l1-positive privacy choices/manage cookies egfr-mutant nsclc primary lung cancer shown high rates complete surgical resection animal subjects performed related subjects hellmann md breast cancer survival iiia completely resected clin lung cancer additional information publisher lung cancer incidence response evaluation criteria small studies support immune therapy activity stage ii-iiia surgical stage iii de miranda nf resectable lung cancer cancer stat facts radiographic response prior pathological complete response patient selection criteria support accelerated approval thoracic cardiovascular surgery meta-analysis underwent surgical assessment osimertinib versus placebo

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         description:Immunotherapy has revolutionized the treatment of non-surgical stage III and stage IV non-small cell lung cancer (NSCLC). Here, we review emerging data on the safety, feasibility, and efficacy of neoadjuvant immunotherapy in the setting of earlier stage surgically resectable lung cancer. Several small studies support the safety and feasibility of neoadjuvant immunotherapy, noting similar perioperative rates of morbidity and mortality compared with historical controls. Data from several phase II trials have shown high rates of major pathologic response (MPR), though it is unclear if this will correlate with a survival benefit. Phase III trials of neoadjuvant immunotherapy alone or in combination with chemotherapy are ongoing. Neoadjuvant immunotherapy offers a promising treatment modality in earlier stage NSCLC patients. Results of ongoing phase II and phase III trials will be essential in determining how to best integrate this treatment modality in the future.
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      description:Immunotherapy has revolutionized the treatment of non-surgical stage III and stage IV non-small cell lung cancer (NSCLC). Here, we review emerging data on the safety, feasibility, and efficacy of neoadjuvant immunotherapy in the setting of earlier stage surgically resectable lung cancer. Several small studies support the safety and feasibility of neoadjuvant immunotherapy, noting similar perioperative rates of morbidity and mortality compared with historical controls. Data from several phase II trials have shown high rates of major pathologic response (MPR), though it is unclear if this will correlate with a survival benefit. Phase III trials of neoadjuvant immunotherapy alone or in combination with chemotherapy are ongoing. Neoadjuvant immunotherapy offers a promising treatment modality in earlier stage NSCLC patients. Results of ongoing phase II and phase III trials will be essential in determining how to best integrate this treatment modality in the future.
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