We are analyzing https://link.springer.com/article/10.1007/s11910-003-0031-z.

Title:
Neuroprotective agents for the treatment of acute ischemic stroke | Current Neurology and Neuroscience Reports
Description:
Neuroprotective treatments are therapies designed to interrupt the cellular, biochemical, and metabolic elaboration of injury during or following exposure to ischemia; they encompass a rapidly expanding array of pharmacologic interventions. Various classes of neuroprotective agents have reached phase III efficacy trials in focal ischemic stroke, but none has proven effective, despite successful preceding animal studies. This notwithstanding, recent favorable results of hypothermia in human cardiac arrest trials have validated the general concept of neuroprotection. In addition, the promise of neuroprotective therapy for focal acute ischemic stroke has been renewed by innovations in strategies of preclinical drug development and clinical trial design that rectify past defects, including trial testing of combination therapies rather than single agents and novel approaches to accelerating time to initiation of experimental treatment.
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Keywords {🔍}

stroke, google, scholar, pubmed, cas, acute, article, ischemic, neuroprotective, trial, study, treatment, trials, neuroprotection, patients, hypothermia, therapy, clinical, investigators, neurology, kidwell, saver, human, starkman, efficacy, focal, results, randomized, international, therapies, injury, ischemia, drugs, cerebral, cerebrovasc, dis, antagonist, privacy, cookies, content, research, agents, cardiac, arrest, design, brain, clark, grotta, med, ischaemic,

Topics {✒️}

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Questions {❓}

De Keyser J, Sulter G, Luiten PG: Clinical trials with neuroprotective drugs in acute ischaemic stroke: are we doing the right thing?
DeGraba TJ, Pettigrew LC: Why do neuroprotective drugs work in animals but not humans?
Gorelick PB: Neuroprotection in acute ischemic stroke: a tale of for whom the bell tolls?
Grotta J: Why do all drugs work in animals but none in stroke patients?
Heiss W, Thiel A, Grond M, Graf R: Which targets are relevant for therapy of acute ischemic stroke?
Samsa GP, Matchar DB: Have randomized controlled trials of neuroprotective drugs been underpowered?
Warach S, Hartnett K: Dose dependent reduction in infarct growth with citicholine treatment: evidence of neuroprotection in human stroke?

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