We are analyzing https://link.springer.com/article/10.1007/s11906-013-0416-6.

Title:
AT2 Receptor and Tissue Injury: Therapeutic Implications | Current Hypertension Reports
Description:
The renin-angiotensin system (RAS) plays an important role in the initiation and progression of tissue injuries in the cardiovascular and nervous systems. The detrimental actions of the AT1 receptor (AT1R) in hypertension and vascular injury, myocardial infarction and brain ischemia are well established. In the past twenty years, protective actions of the RAS, not only in the cardiovascular, but also in the nervous system, have been demonstrated. The so-called protective arm of the RAS includes AT2-receptors and Mas receptors (AT2R and MasR) and is characterized by effects different from and often opposing those of the AT1R. These include anti-inflammation, anti-fibrosis, anti-apoptosis and neuroregeneration that can counterbalance pathological processes and enable recovery from disease. The recent development of novel, small-molecule AT2R agonists offers a therapeutic potential in humans with a variety of clinical indications.
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Keywords {🔍}

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Topics {✒️}

nω-nitro-l-arginine-methyl ester-induced hypertension spinal cord injury c-jun n-terminal kinase aortic root aneurysm integrated view renin–angiotensin–aldosterone system afford long-term cardioprotection sébastien foulquier renin-angiotensin-aldosterone syst mitogen-activated protein kinase aortic aneurysm at2r-mediated anti-fibrosis appears renin-angiotensin system renin-angiotensin-system at2 receptor-interacting protein angiotensin at2 receptor–implications afford tissue/organ protection angiotensin ii-mediated apoptosis mitogen-activated protein kinases at2 receptor-mediated apoptosis n-methyl-d-aspartate at2r-mediated anti-atherogenic actions direct at2-receptor stimulation at2r-mediated tissue protection peptide at2-receptor agonists at2r-mediated anti-inflammatory actions experimental myocardial infarction ras includes at2-receptors angiotensin ii stimulates mitogen-activated protein angiotensin ii receptors central nervous system transcription factor nf-kappab moderate cardio-selective overexpression at2 receptor-independent mechanism apolipoprotein e-deficient mice at2r-mediated anti-inflammation angiotensin at2 receptor stroke-induced superoxide production ulrike muscha steckelings brain-derived neurotrophic factor modulates t-cell differentiation author information authors anti-inflammatory actions induced apolipoprotein e-null mice moderate cardiac-selective overexpression nerve growth factor anti-inflammatory pattern tetracyclin-regulated system ang ii-mediated effect

Questions {❓}

Angiotensin II type 2 receptor agonists–where should they be applied?
Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction?
How does angiotensin AT(2) receptor activation help neuronal differentiation and improve neuronal pathological situations?

Schema {🗺️}

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         headline:AT2 Receptor and Tissue Injury: Therapeutic Implications
         description:The renin-angiotensin system (RAS) plays an important role in the initiation and progression of tissue injuries in the cardiovascular and nervous systems. The detrimental actions of the AT1 receptor (AT1R) in hypertension and vascular injury, myocardial infarction and brain ischemia are well established. In the past twenty years, protective actions of the RAS, not only in the cardiovascular, but also in the nervous system, have been demonstrated. The so-called protective arm of the RAS includes AT2-receptors and Mas receptors (AT2R and MasR) and is characterized by effects different from and often opposing those of the AT1R. These include anti-inflammation, anti-fibrosis, anti-apoptosis and neuroregeneration that can counterbalance pathological processes and enable recovery from disease. The recent development of novel, small-molecule AT2R agonists offers a therapeutic potential in humans with a variety of clinical indications.
         datePublished:2014-01-11T00:00:00Z
         dateModified:2014-01-11T00:00:00Z
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ScholarlyArticle:
      headline:AT2 Receptor and Tissue Injury: Therapeutic Implications
      description:The renin-angiotensin system (RAS) plays an important role in the initiation and progression of tissue injuries in the cardiovascular and nervous systems. The detrimental actions of the AT1 receptor (AT1R) in hypertension and vascular injury, myocardial infarction and brain ischemia are well established. In the past twenty years, protective actions of the RAS, not only in the cardiovascular, but also in the nervous system, have been demonstrated. The so-called protective arm of the RAS includes AT2-receptors and Mas receptors (AT2R and MasR) and is characterized by effects different from and often opposing those of the AT1R. These include anti-inflammation, anti-fibrosis, anti-apoptosis and neuroregeneration that can counterbalance pathological processes and enable recovery from disease. The recent development of novel, small-molecule AT2R agonists offers a therapeutic potential in humans with a variety of clinical indications.
      datePublished:2014-01-11T00:00:00Z
      dateModified:2014-01-11T00:00:00Z
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      pageEnd:10
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         Renin-angiotensin system
         AT2 receptor
         Angiotensin II
         CGP42112
         PD123319
         Signaling
         Tissue injury
         Inflammation
         Fibrosis
         Apoptosis
         Growth promotion/inhibition
         Cardioprotection
         Vascular protection
         Neuroprotection
         Neuroregeneration
         Myocardial infarction
         Aortic aneurysm
         Atherosclerosis
         Hypertension
         Stroke
         Spinal cord injury
         Internal Medicine
         Cardiology
         Metabolic Diseases
         Nephrology
         Primary Care Medicine
         General Practice / Family Medicine
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               name:CARIM - School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands
               type:PostalAddress
            type:Organization
      name:Ulrike Muscha Steckelings
      affiliation:
            name:University of Southern Denmark
            address:
               name:Institute of Molecular Medicine, Department of Cardiovascular and Renal Physiology, University of Southern Denmark, Odense, Denmark
               type:PostalAddress
            type:Organization
      name:Thomas Unger
      affiliation:
            name:Maastricht University
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      name:Institute of Molecular Medicine, Department of Cardiovascular and Renal Physiology, University of Southern Denmark, Odense, Denmark
      name:CARIM - School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands

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