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Title:
Metabolomics of Diabetic Retinopathy | Current Diabetes Reports
Description:
Purpose of Review Metabolomics is the study of dysregulated metabolites in biological materials. We reviewed the use of the technique to elucidate the genetic and environmental factors that contribute to the development of diabetic retinopathy. Recent Findings With regard to metabolomic studies of diabetic retinopathy, the field remains in its infancy with few studies published to date and little replication of results. Vitreous and serum samples are the main tissues examined, and dysregulation in pathways such as the pentose phosphate pathway, arginine to proline pathway, polyol pathway, and ascorbic acidic pathways have been reported. Summary Few studies have examined the metabolomic underpinnings of diabetic retinopathy. Further research is required to replicate findings to date and determine longitudinal associations with disease.
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pubmed, article, google, scholar, cas, diabetic, retinopathy, diabetes, central, metabolomics, research, sydney, liew, content, gerald, metabolomic, res, acid, privacy, cookies, tan, ivan, studies, pathway, ascorbic, access, human, university, australia, analysis, information, publish, search, published, lei, wong, study, vitreous, acids, complications, med, invest, insulin, retina, support, data, log, journal, reports, microvascular,
Topics {✒️}
1h-nmr-based metabonomic approach month download article/chapter gas chromatography-mass spectrometry rat blood-retinal barrier i-van ho branched-chain amino acids microvascular complications—retinopathy access gc-tofms-based approach rat blood-retinal mendelian randomisation analysis full article pdf plasma metabonomic profiling human metabolome database ben crossett declare ascorbic acidic pathways privacy choices/manage cookies circulating inflammatory markers constrict blood vessels bamini gopinath article liew gavin tan reports proliferative diabetic retinopathy cell death dis related subjects animal subjects performed nucleic acids res exp eye res exp diabetes res robust metabolomics techniques isolated rat retina improves diabetes prediction european economic area determine longitudinal associations rhee ep lipid profiling identifies dehydroascorbic acid transport biol pharm bull article log conditions privacy policy gerald liew main tissues examined genetically determined metabolites glial cells dilate westmead millennium institute article number 102 med res rev pentose phosphate pathway accepting optional cookies lipid regulation occur banerjee sp
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headline:Metabolomics of Diabetic Retinopathy
description:Metabolomics is the study of dysregulated metabolites in biological materials. We reviewed the use of the technique to elucidate the genetic and environmental factors that contribute to the development of diabetic retinopathy. With regard to metabolomic studies of diabetic retinopathy, the field remains in its infancy with few studies published to date and little replication of results. Vitreous and serum samples are the main tissues examined, and dysregulation in pathways such as the pentose phosphate pathway, arginine to proline pathway, polyol pathway, and ascorbic acidic pathways have been reported. Few studies have examined the metabolomic underpinnings of diabetic retinopathy. Further research is required to replicate findings to date and determine longitudinal associations with disease.
datePublished:2017-09-23T00:00:00Z
dateModified:2017-09-23T00:00:00Z
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Diabetic retinopathy
Metabolomics
Metabonomic
Blood
Arginine
Ascorbic acid
Diabetes
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headline:Metabolomics of Diabetic Retinopathy
description:Metabolomics is the study of dysregulated metabolites in biological materials. We reviewed the use of the technique to elucidate the genetic and environmental factors that contribute to the development of diabetic retinopathy. With regard to metabolomic studies of diabetic retinopathy, the field remains in its infancy with few studies published to date and little replication of results. Vitreous and serum samples are the main tissues examined, and dysregulation in pathways such as the pentose phosphate pathway, arginine to proline pathway, polyol pathway, and ascorbic acidic pathways have been reported. Few studies have examined the metabolomic underpinnings of diabetic retinopathy. Further research is required to replicate findings to date and determine longitudinal associations with disease.
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Diabetic retinopathy
Metabolomics
Metabonomic
Blood
Arginine
Ascorbic acid
Diabetes
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