We are analyzing https://link.springer.com/article/10.1007/s11686-024-00979-9.

Title:
Colchicine: A Dual Therapeutic Target for Trichinellosis | Acta Parasitologica
Description:
Purpose Trichinellosis affects around 11 million people globally. Treatments for this medical condition are limited by adverse effects and resistance, emphasising the importance of effective and safe therapies. Consequentially, we sought to study colchicine’s synergistic effects with atorvastatin or acetazolamide in the treatment of Trichinella spiralis (T. spiralis)-infected mice. Methods Seventy mice were evenly divided into two groups (a and b) of 35 each. During the intestinal phase, group (a) began therapy on the second day post-infection (dpi) and lasted four days. Group (b) had treatment for four weeks during the muscle phase, beginning on the 12th dpi. While the other five infected groups received atorvastatin, colchicine, acetazolamide, a combination of acetazolamide and colchicine, or none, one group of infected mice received no treatment at all as a negative control. The efficacy was assessed by parasite count, histopathology and scanning electron microscopy. Results Our data revealed that the combination treatment lowered T. spiralis adult worm and larvae counts in infected animals. Moreover, it restored the normal intestinal and muscular architecture, reduced edema, and alleviated inflammation, as demonstrated by reduced inflammatory infiltrate. Scanning electron microscopic examination of adults and larvae verified our findings. Conclusion Adjuvant treatment with colchicine as an antifibrotic can help treat muscle trichinellosis by reducing the production of fibrous tissue. This might help to enhance treatment results by enabling the admission of larvicidal medications and, as a result, reducing the number of larvae in the muscle, which together form the basis of pathology and can be debilitating for the patient.
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Keywords {🔍}

larvae, spiralis, colchicine, article, google, scholar, muscle, arrows, mice, trichinella, pubmed, groups, inflammatory, fig, acetazolamide, cas, trichinellosis, intestinal, atorvastatin, group, therapy, adult, adults, treatment, larval, mucosal, arrow, normal, invasion, tissue, cells, moderate, therapeutic, green, count, table, encysted, blue, number, infected, experimental, significant, surrounding, showed, lymphocytes, effects, gva, mild, yellow, multiple,

Topics {✒️}

article download pdf rhoa/rho effector kinase muscle-stage trichinella spiralis elucidate host–pathogen interactions tumour necrosis factor-alpha long-term survival inside beta-class carbonic anhydrases beta-class carbonic anhydrase alkaloid anti-mitotic agent regulated light/dark cycle acetazolamide loaded-silver nanoparticles subsequent day post-infection 45th day post-intervention full size image scanning electron microscopy achieve anti-helminthic efficacy group v-infected mice group vι-infected mice group vii-infected mice full size table mature t-spiralis counts privacy choices/manage cookies full access gvii experienced thinning familial mediterranean fever beta carbonic anhydrases including fast absorption single therapy showed related subjects group iv-infected mice article hamed oral gavage daily 10% neutral-buffered formalin transformed mesenchymal tissue encapsulated nurse cell drug dosage schedule increased drug permeability focal pressure atrophy day post-infection cell injury caused moderate inflammatory reaction laboratory standards institute references borhani acute schistosomiasis mansoni carbonic anhydrase enzyme thin fibrous capsule combination treatment aims nurse cell collagen surrounding intestinal mucosa 200 µg/kg/day [19]

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