We are analyzing https://link.springer.com/article/10.1007/s11596-022-2579-3.

Title:
Insight into Crosstalk Between Mitophagy and Apoptosis/Necroptosis: Mechanisms and Clinical Applications in Ischemic Stroke | Current Medical Science
Description:
Ischemic stroke is a serious cerebrovascular disease with high morbidity and mortality. As a result of ischemia-reperfusion, a cascade of pathophysiological responses is triggered by the imbalance in metabolic supply and demand, resulting in cell loss. These cellular injuries follow various molecular mechanisms solely or in combination with this disorder. Mitochondria play a driving role in the pathophysiological processes of ischemic stroke. Once ischemic stroke occurs, damaged cells would respond to such stress through mitophagy. Mitophagy is known as a conservatively selective autophagy, contributing to the removal of excessive protein aggregates and damaged intracellular components, as well as aging mitochondria. Moderate mitophagy may exert neuroprotection against stroke. Several pathways associated with the mitochondrial network collectively contribute to recovering the homeostasis of the neurovascular unit. However, excessive mitophagy would also promote ischemia-reperfusion injury. Therefore, mitophagy is a double-edged sword, which suggests that maximizing the benefits of mitophagy is one of the direction of future efforts. This review emphasized the role of mitophagy in ischemic stroke, and highlighted the crosstalk between mitophagy and apoptosis/necroptosis.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Science
Health & Fitness

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,734,772 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We don’t know how the website earns money.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Link.springer.com might be cashing in, but we can't detect the method they're using.

Keywords {🔍}

article, google, scholar, cas, mitophagy, mitochondrial, stroke, ischemic, cell, injury, med, biol, res, mitochondria, zhang, autophagy, ischemiareperfusion, mol, sci, parkin, cerebral, apoptosis, necroptosis, mechanisms, chen, wang, pink, yang, role, acute, death, front, medical, kun, xiong, disease, molecular, stress, therapeutic, target, brain, int, neural, regen, nat, activation, zhu, china, function, research,

Topics {✒️}

cerebral ischemia-reperfusion injury promote ischemia-reperfusion injury myocardial ischemia/reperfusion injury calcium-induced mitochondrial swelling drp1-activated mitochondrial fission pink1/parkin-mediated mitophagy clearance bnip3l/nix-mediated mitophagy protects glucocorticoid-induced synapse defects article download pdf drp1/mff signaling pathway fluoride-induced abnormal fission steroid-induced osteocytes apoptosis maintaining er-mitochondrial contacts hypoxia-inducible factor induction risk factor-based approach fundc1-dependent mitophagy induced damage-induced mitochondrial localization current medical science ischemia/reperfusion injury ischemia-reperfusion injury tissue-type plasminogen activator pro-apoptotic mitochondrial proteins site-specific interaction mapping activating bnip3-mediated mitophagy cerebral ischemia-reperfusion hypoxia-induced autophagy conventional kinase activity pink1/parkin-mediated mitophagy author kun xiong basic medical science xi-min hu hypoxic ischemic injury dynamin-related protein 1 inhibiting neuronal apoptosis cardiac ir injury acute ischemic stroke zi-xin li privacy choices/manage cookies ischemic stroke research excessive protein aggregates cerebral ischemic stroke ischemic brain damage early management strategies tissue plasminogen activator hainan medical university post-ischemic heart pink1/parkin pathway tpa protects neurons delayed neuronal death hypoxic/ischemic stress

Questions {❓}

Do pyroptosis, apoptosis, and necroptosis (PANoptosis) exist in cerebral ischemia?
To mdivi-1 or not to mdivi-1: Is that the question?

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Insight into Crosstalk Between Mitophagy and Apoptosis/Necroptosis: Mechanisms and Clinical Applications in Ischemic Stroke
         description:Ischemic stroke is a serious cerebrovascular disease with high morbidity and mortality. As a result of ischemia-reperfusion, a cascade of pathophysiological responses is triggered by the imbalance in metabolic supply and demand, resulting in cell loss. These cellular injuries follow various molecular mechanisms solely or in combination with this disorder. Mitochondria play a driving role in the pathophysiological processes of ischemic stroke. Once ischemic stroke occurs, damaged cells would respond to such stress through mitophagy. Mitophagy is known as a conservatively selective autophagy, contributing to the removal of excessive protein aggregates and damaged intracellular components, as well as aging mitochondria. Moderate mitophagy may exert neuroprotection against stroke. Several pathways associated with the mitochondrial network collectively contribute to recovering the homeostasis of the neurovascular unit. However, excessive mitophagy would also promote ischemia-reperfusion injury. Therefore, mitophagy is a double-edged sword, which suggests that maximizing the benefits of mitophagy is one of the direction of future efforts. This review emphasized the role of mitophagy in ischemic stroke, and highlighted the crosstalk between mitophagy and apoptosis/necroptosis.
         datePublished:2022-04-07T00:00:00Z
         dateModified:2022-04-07T00:00:00Z
         pageStart:237
         pageEnd:248
         license:http://creativecommons.org/licenses/by/4.0/
         sameAs:https://doi.org/10.1007/s11596-022-2579-3
         keywords:
            mitophagy
            ischemic stroke
            apoptosis
            necroptosis
            clinical application
            crosstalk
            Medicine/Public Health
            general
         image:
         isPartOf:
            name:Current Medical Science
            issn:
               2523-899X
               2096-5230
            volumeNumber:42
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Huazhong University of Science and Technology
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Yan-di Yang
               affiliation:
                     name:Central South University
                     address:
                        name:Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Zi-xin Li
               affiliation:
                     name:Central South University
                     address:
                        name:Clinical Medicine Eight-year Program, 03 Class, 18 Grade, Xiangya School of Medicine, Central South University, Changsha, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Xi-min Hu
               affiliation:
                     name:Central South University
                     address:
                        name:Clinical Medicine Eight-Year Program, 02 Class, 17 Grade, Xiangya School of Medicine, Central South University, Changsha, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Hao Wan
               affiliation:
                     name:Central South University
                     address:
                        name:Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Qi Zhang
               affiliation:
                     name:Central South University
                     address:
                        name:Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Rui Xiao
               affiliation:
                     name:Central South University
                     address:
                        name:Administrative Office, the Third Xiangya Hospital, Central South University, Changsha, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
               name:Kun Xiong
               affiliation:
                     name:Central South University
                     address:
                        name:Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China
                        type:PostalAddress
                     type:Organization
                     name:Hunan Key Laboratory of Ophthalmology
                     address:
                        name:Hunan Key Laboratory of Ophthalmology, Changsha, China
                        type:PostalAddress
                     type:Organization
                     name:Hainan Medical University
                     address:
                        name:Key Laboratory of Emergency and Trauma, Ministry of Education, College of Emergency and Trauma, Hainan Medical University, Haikou, China
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:1
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Insight into Crosstalk Between Mitophagy and Apoptosis/Necroptosis: Mechanisms and Clinical Applications in Ischemic Stroke
      description:Ischemic stroke is a serious cerebrovascular disease with high morbidity and mortality. As a result of ischemia-reperfusion, a cascade of pathophysiological responses is triggered by the imbalance in metabolic supply and demand, resulting in cell loss. These cellular injuries follow various molecular mechanisms solely or in combination with this disorder. Mitochondria play a driving role in the pathophysiological processes of ischemic stroke. Once ischemic stroke occurs, damaged cells would respond to such stress through mitophagy. Mitophagy is known as a conservatively selective autophagy, contributing to the removal of excessive protein aggregates and damaged intracellular components, as well as aging mitochondria. Moderate mitophagy may exert neuroprotection against stroke. Several pathways associated with the mitochondrial network collectively contribute to recovering the homeostasis of the neurovascular unit. However, excessive mitophagy would also promote ischemia-reperfusion injury. Therefore, mitophagy is a double-edged sword, which suggests that maximizing the benefits of mitophagy is one of the direction of future efforts. This review emphasized the role of mitophagy in ischemic stroke, and highlighted the crosstalk between mitophagy and apoptosis/necroptosis.
      datePublished:2022-04-07T00:00:00Z
      dateModified:2022-04-07T00:00:00Z
      pageStart:237
      pageEnd:248
      license:http://creativecommons.org/licenses/by/4.0/
      sameAs:https://doi.org/10.1007/s11596-022-2579-3
      keywords:
         mitophagy
         ischemic stroke
         apoptosis
         necroptosis
         clinical application
         crosstalk
         Medicine/Public Health
         general
      image:
      isPartOf:
         name:Current Medical Science
         issn:
            2523-899X
            2096-5230
         volumeNumber:42
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Huazhong University of Science and Technology
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Yan-di Yang
            affiliation:
                  name:Central South University
                  address:
                     name:Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Zi-xin Li
            affiliation:
                  name:Central South University
                  address:
                     name:Clinical Medicine Eight-year Program, 03 Class, 18 Grade, Xiangya School of Medicine, Central South University, Changsha, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Xi-min Hu
            affiliation:
                  name:Central South University
                  address:
                     name:Clinical Medicine Eight-Year Program, 02 Class, 17 Grade, Xiangya School of Medicine, Central South University, Changsha, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Hao Wan
            affiliation:
                  name:Central South University
                  address:
                     name:Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Qi Zhang
            affiliation:
                  name:Central South University
                  address:
                     name:Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Rui Xiao
            affiliation:
                  name:Central South University
                  address:
                     name:Administrative Office, the Third Xiangya Hospital, Central South University, Changsha, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
            name:Kun Xiong
            affiliation:
                  name:Central South University
                  address:
                     name:Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China
                     type:PostalAddress
                  type:Organization
                  name:Hunan Key Laboratory of Ophthalmology
                  address:
                     name:Hunan Key Laboratory of Ophthalmology, Changsha, China
                     type:PostalAddress
                  type:Organization
                  name:Hainan Medical University
                  address:
                     name:Key Laboratory of Emergency and Trauma, Ministry of Education, College of Emergency and Trauma, Hainan Medical University, Haikou, China
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:1
["Periodical","PublicationVolume"]:
      name:Current Medical Science
      issn:
         2523-899X
         2096-5230
      volumeNumber:42
Organization:
      name:Huazhong University of Science and Technology
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Central South University
      address:
         name:Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China
         type:PostalAddress
      name:Central South University
      address:
         name:Clinical Medicine Eight-year Program, 03 Class, 18 Grade, Xiangya School of Medicine, Central South University, Changsha, China
         type:PostalAddress
      name:Central South University
      address:
         name:Clinical Medicine Eight-Year Program, 02 Class, 17 Grade, Xiangya School of Medicine, Central South University, Changsha, China
         type:PostalAddress
      name:Central South University
      address:
         name:Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China
         type:PostalAddress
      name:Central South University
      address:
         name:Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China
         type:PostalAddress
      name:Central South University
      address:
         name:Administrative Office, the Third Xiangya Hospital, Central South University, Changsha, China
         type:PostalAddress
      name:Central South University
      address:
         name:Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China
         type:PostalAddress
      name:Hunan Key Laboratory of Ophthalmology
      address:
         name:Hunan Key Laboratory of Ophthalmology, Changsha, China
         type:PostalAddress
      name:Hainan Medical University
      address:
         name:Key Laboratory of Emergency and Trauma, Ministry of Education, College of Emergency and Trauma, Hainan Medical University, Haikou, China
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Yan-di Yang
      affiliation:
            name:Central South University
            address:
               name:Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China
               type:PostalAddress
            type:Organization
      name:Zi-xin Li
      affiliation:
            name:Central South University
            address:
               name:Clinical Medicine Eight-year Program, 03 Class, 18 Grade, Xiangya School of Medicine, Central South University, Changsha, China
               type:PostalAddress
            type:Organization
      name:Xi-min Hu
      affiliation:
            name:Central South University
            address:
               name:Clinical Medicine Eight-Year Program, 02 Class, 17 Grade, Xiangya School of Medicine, Central South University, Changsha, China
               type:PostalAddress
            type:Organization
      name:Hao Wan
      affiliation:
            name:Central South University
            address:
               name:Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China
               type:PostalAddress
            type:Organization
      name:Qi Zhang
      affiliation:
            name:Central South University
            address:
               name:Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China
               type:PostalAddress
            type:Organization
      name:Rui Xiao
      affiliation:
            name:Central South University
            address:
               name:Administrative Office, the Third Xiangya Hospital, Central South University, Changsha, China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Kun Xiong
      affiliation:
            name:Central South University
            address:
               name:Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China
               type:PostalAddress
            type:Organization
            name:Hunan Key Laboratory of Ophthalmology
            address:
               name:Hunan Key Laboratory of Ophthalmology, Changsha, China
               type:PostalAddress
            type:Organization
            name:Hainan Medical University
            address:
               name:Key Laboratory of Emergency and Trauma, Ministry of Education, College of Emergency and Trauma, Hainan Medical University, Haikou, China
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China
      name:Clinical Medicine Eight-year Program, 03 Class, 18 Grade, Xiangya School of Medicine, Central South University, Changsha, China
      name:Clinical Medicine Eight-Year Program, 02 Class, 17 Grade, Xiangya School of Medicine, Central South University, Changsha, China
      name:Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China
      name:Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China
      name:Administrative Office, the Third Xiangya Hospital, Central South University, Changsha, China
      name:Department of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha, China
      name:Hunan Key Laboratory of Ophthalmology, Changsha, China
      name:Key Laboratory of Emergency and Trauma, Ministry of Education, College of Emergency and Trauma, Hainan Medical University, Haikou, China

Social Networks {👍}(1)

https://link.springer.com/article/10.1007/s11596-022-2579-3/mailto:[email protected]

External Links {🔗}(254)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

5.73s.

LINK . SPRINGER . COM {}