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  1. Analyzed Page
  2. Matching Content Categories
  3. CMS
  4. Monthly Traffic Estimate
  5. How Does Link.springer.com Make Money
  6. Keywords
  7. Topics
  8. Schema
  9. External Links
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We are analyzing https://link.springer.com/article/10.1007/s11523-016-0435-8.

Title:
An Adaptive Study to Determine the Optimal Dose of the Tablet Formulation of the PARP Inhibitor Olaparib | Targeted Oncology
Description:
Olaparib is poorly soluble, requiring advanced drug delivery technologies for adequate bioavailability. Sixteen capsules/day are required for the approved 400 mg twice-daily dose; a tablet formulation was developed to reduce pill burden. This clinical trial evaluated the optimal dose and administration schedule of the tablet formulation. Two stages of sequentially enrolled cohorts: stage 1, pharmacokinetic properties of tablet and capsule formulations were compared in patients with advanced solid tumours; stage 2, tablet dose escalation with expansion cohorts at doses/schedules of interest in patients with solid tumours and BRCAm breast/ovarian cancers. Olaparib 200 mg tablets displayed similar Cmax,ss, but lower AUCss and Cmin,ss than 400 mg capsules. Following multiple dosing, steady-state exposure with tablets ≥300 mg matched or exceeded that of 400 mg capsules. After dose escalation, while 400 mg twice daily was the tablet maximum tolerated dose based on haematological toxicity, 65 % of patients in the randomized expansion phase eventually required dose reduction to 300 mg. Intermittent tablet administration did not significantly improve tolerability. Tumour shrinkage was similar for 300 and 400 mg tablet and 400 mg capsule cohorts. The recommended monotherapy dose of olaparib tablet for Phase III trials was 300 mg twice daily, simplifying drug administration from 16 capsules to four tablets per day. NCT00777582 (ClinicalTrials.gov)
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

  • Education
  • Health & Fitness
  • Non-Profit & Charity

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 7,643,078 visitors per month in the current month.

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How Does Link.springer.com Make Money? {💸}

We can't see how the site brings in money.

Not all websites focus on profit; some are designed to educate, connect people, or share useful tools. People create websites for numerous reasons. And this could be one such example. Link.springer.com might have a hidden revenue stream, but it's not something we can detect.

Keywords {🔍}

cancer, article, pubmed, google, scholar, olaparib, cas, astrazeneca, patients, research, ovarian, tablet, brca, study, dose, phase, funding, advanced, clinical, trial, oncol, advisory, oncology, institute, received, board, solid, polymerase, mutations, lancet, attendance, privacy, cookies, content, personal, formulation, inhibitor, drug, tumours, trials, access, nature, polyadpribose, breast, centre, university, publish, search, gourley, ledermann,

Topics {✒️}

/media/press-releases/article/20141218--lynparza-approved gov/drugs/informationondrugs/approveddrugs/ucm427598 recurrent high-grade serous month download article/chapter brcam breast/ovarian cancers triple-negative breast cancer early-phase clinical trials ovarian carcinoma cases /responsibility/code-policies-standards/ simplifying drug administration germ-line brca1/2 mutation population pharmacokinetic meta-analysis recurrent ovarian cancer full article pdf epithelial ovarian cancer ovarian carcinoma tablet dose escalation privacy choices/manage cookies olaparib maintenance therapy advanced breast cancer advanced solid tumours recommended monotherapy dose steady-state exposure phase iii trials parp inhibitor olaparib national research committee investigator-initiated trials clinical trial evaluated medical writing assistance natl cancer inst gynecological cancer intergroup individual participants included wales clinical school brca mutation carriers cancer research uk brca2-deficient tumours tablets ≥300 mg matched cancer therapy intermittent tablet administration scope submit manuscript reduce pill burden check access integrated genomic analyses gene expression profile claire routley phd attended advisory boards ema regulatory submission bristol-myers squibb advisory board attendance advisory board payment

Schema {🗺️}

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         headline:An Adaptive Study to Determine the Optimal Dose of the Tablet Formulation of the PARP Inhibitor Olaparib
         description:Olaparib is poorly soluble, requiring advanced drug delivery technologies for adequate bioavailability. Sixteen capsules/day are required for the approved 400 mg twice-daily dose; a tablet formulation was developed to reduce pill burden. This clinical trial evaluated the optimal dose and administration schedule of the tablet formulation. Two stages of sequentially enrolled cohorts: stage 1, pharmacokinetic properties of tablet and capsule formulations were compared in patients with advanced solid tumours; stage 2, tablet dose escalation with expansion cohorts at doses/schedules of interest in patients with solid tumours and BRCAm breast/ovarian cancers. Olaparib 200 mg tablets displayed similar Cmax,ss, but lower AUCss and Cmin,ss than 400 mg capsules. Following multiple dosing, steady-state exposure with tablets ≥300 mg matched or exceeded that of 400 mg capsules. After dose escalation, while 400 mg twice daily was the tablet maximum tolerated dose based on haematological toxicity, 65 % of patients in the randomized expansion phase eventually required dose reduction to 300 mg. Intermittent tablet administration did not significantly improve tolerability. Tumour shrinkage was similar for 300 and 400 mg tablet and 400 mg capsule cohorts. The recommended monotherapy dose of olaparib tablet for Phase III trials was 300 mg twice daily, simplifying drug administration from 16 capsules to four tablets per day. NCT00777582 (ClinicalTrials.gov)
         datePublished:2016-05-12T00:00:00Z
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      headline:An Adaptive Study to Determine the Optimal Dose of the Tablet Formulation of the PARP Inhibitor Olaparib
      description:Olaparib is poorly soluble, requiring advanced drug delivery technologies for adequate bioavailability. Sixteen capsules/day are required for the approved 400 mg twice-daily dose; a tablet formulation was developed to reduce pill burden. This clinical trial evaluated the optimal dose and administration schedule of the tablet formulation. Two stages of sequentially enrolled cohorts: stage 1, pharmacokinetic properties of tablet and capsule formulations were compared in patients with advanced solid tumours; stage 2, tablet dose escalation with expansion cohorts at doses/schedules of interest in patients with solid tumours and BRCAm breast/ovarian cancers. Olaparib 200 mg tablets displayed similar Cmax,ss, but lower AUCss and Cmin,ss than 400 mg capsules. Following multiple dosing, steady-state exposure with tablets ≥300 mg matched or exceeded that of 400 mg capsules. After dose escalation, while 400 mg twice daily was the tablet maximum tolerated dose based on haematological toxicity, 65 % of patients in the randomized expansion phase eventually required dose reduction to 300 mg. Intermittent tablet administration did not significantly improve tolerability. Tumour shrinkage was similar for 300 and 400 mg tablet and 400 mg capsule cohorts. The recommended monotherapy dose of olaparib tablet for Phase III trials was 300 mg twice daily, simplifying drug administration from 16 capsules to four tablets per day. NCT00777582 (ClinicalTrials.gov)
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      dateModified:2016-05-12T00:00:00Z
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         Oncology
         Biomedicine
         general
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                     name:Drug Development Unit, The Royal Marsden/The Institute of Cancer Research, Sutton, UK
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                     type:PostalAddress
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            affiliation:
                  name:The Christie NHS Foundation Trust/University of Manchester
                  address:
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                     type:PostalAddress
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            name:M. R. Middleton
            affiliation:
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                  address:
                     name:Department of Oncology, University of Oxford, Oxford, UK
                     type:PostalAddress
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            name:M. Friedlander
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                     type:PostalAddress
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            affiliation:
                  name:Oncology Institute of Southern Switzerland
                  address:
                     name:Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
                     type:PostalAddress
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            name:K. Leunen
            affiliation:
                  name:University Hospitals Leuven
                  address:
                     name:Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals Leuven, Leuven, Belgium
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            name:University Hospitals Leuven
            address:
               name:Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals Leuven, Leuven, Belgium
               type:PostalAddress
            type:Organization
      name:J. Ledermann
      affiliation:
            name:UCL Hospitals and UCL Cancer Institute
            address:
               name:UCL Hospitals and UCL Cancer Institute, London, UK
               type:PostalAddress
            type:Organization
      name:H. Swaisland
      affiliation:
            name:AstraZeneca
            address:
               name:AstraZeneca, Macclesfield, UK
               type:PostalAddress
            type:Organization
      name:A. Fielding
      affiliation:
            name:AstraZeneca
            address:
               name:AstraZeneca, Macclesfield, UK
               type:PostalAddress
            type:Organization
      name:W. Bannister
      affiliation:
            name:PHASTAR
            address:
               name:PHASTAR, London, UK
               type:PostalAddress
            type:Organization
      name:S. Nicum
      affiliation:
            name:University of Oxford
            address:
               name:Department of Oncology, University of Oxford, Oxford, UK
               type:PostalAddress
            type:Organization
      name:L. R. Molife
      affiliation:
            name:The Royal Marsden/The Institute of Cancer Research
            address:
               name:Drug Development Unit, The Royal Marsden/The Institute of Cancer Research, Sutton, UK
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Drug Development Unit, The Royal Marsden/The Institute of Cancer Research, Sutton, UK
      name:Drug Development Unit, The Royal Marsden/The Institute of Cancer Research, Sutton, UK
      name:Department of Oncology, University of Oxford, Oxford, UK
      name:Drug Development Unit, The Royal Marsden/The Institute of Cancer Research, Sutton, UK
      name:Clinical Trials Unit, The Christie NHS Foundation Trust/University of Manchester, Manchester, UK
      name:Department of Oncology, University of Oxford, Oxford, UK
      name:Prince of Wales Clinical School, University of New South Wales, Prince of Wales Hospital, Randwick, Australia
      name:University of Edinburgh Cancer Research UK Centre, MRC IGMM, Edinburgh, UK
      name:Northern Centre for Cancer Care, Newcastle-upon-Tyne, UK
      name:Mount Vernon Hospital, Northwood, UK
      name:Oncology Institute of Southern Switzerland, Bellinzona, Switzerland
      name:Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University Hospitals Leuven, Leuven, Belgium
      name:UCL Hospitals and UCL Cancer Institute, London, UK
      name:AstraZeneca, Macclesfield, UK
      name:AstraZeneca, Macclesfield, UK
      name:PHASTAR, London, UK
      name:Department of Oncology, University of Oxford, Oxford, UK
      name:Drug Development Unit, The Royal Marsden/The Institute of Cancer Research, Sutton, UK
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