We are analyzing https://link.springer.com/article/10.1007/s11427-017-9183-4.

Title:
Formation and repair of DNA-protein crosslink damage | Science China Life Sciences
Description:
DNA is constantly exposed to a wide array of genotoxic agents, generating a variety of forms of DNA damage. DNA-protein crosslinks (DPCs)—the covalent linkage of proteins with a DNA strand—are one of the most deleterious and understudied forms of DNA damage, posing as steric blockades to transcription and replication. If not properly repaired, these lesions can lead to mutations, genomic instability, and cell death. DPCs can be induced endogenously or through environmental carcinogens and chemotherapeutic agents. Endogenously, DPCs are commonly derived through reactions with aldehydes, as well as through trapping of various enzymatic intermediates onto the DNA. Proteolytic cleavage of the protein moiety of a DPC is a general strategy for removing the lesion. This can be accomplished through a DPC-specific protease and and/or proteasome-mediated degradation. Nucleotide excision repair and homologous recombination are each involved in repairing DPCs, with their respective roles likely dependent on the nature and size of the adduct. The Fanconi anemia pathway may also have a role in processing DPC repair intermediates. In this review, we discuss how these lesions are formed, strategies and mechanisms for their removal, and diseases associated with defective DPC repair.
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Keywords {🔍}

pubmed, article, google, scholar, cas, dna, repair, central, dnaprotein, crosslinks, res, biol, damage, cell, chem, cells, human, crosslink, excision, sci, mol, usa, cancer, mutat, nucleic, acids, toxicol, nature, fanconi, crosslinking, formation, nucleotide, mammalian, formaldehyde, proc, natl, acad, lei, replication, protein, access, zhitkovich, nat, topoisomerase, base, van, lloyd, tretyakova, privacy, cookies,

Topics {✒️}

encountering dna-protein cross-links dna-protein cross-links conjugated dna-protein cross-links induced dna–protein cross-link repair model dna-peptide cross-link dna-protein cross-links produced rapid dna-protein cross-linking covalent dna-protein cross-links month download article/chapter formaldehyde-induced dna-protein crosslinks site-specific dna-protein conjugates dna-protein crosslink damage dna-protein crosslink repair dna-dependent metalloprotease sprtn dna-protein cross-links nucleotide excision repair diamminedichloride dna-protein crosslinks resolves dna-protein crosslinks dna-polypeptide cross-links dna-protein cross-linking china life sci dna-peptide crosslinks mediated article klages-mundt trans-4-hydroxynonenal cross-link klages-mundt & lei li peptide-catalyzed β-elimination promotes ubiquitin-dependent responses topoisomerase-mediated dna damage mammalian dna-binding metalloprotease formaldehyde-mediated dnaprotein crosslinking formaldehyde-induced dnaprotein crosslinks excision-deficient human cells dna-protein crosslink fanconi anemia pathway prevent uv-induced mutagenesis acrolein-derived dna adducts dna-dependent protease involved acetaldehyde-induced chromosomal alterations dna crosslinking damage formaldehyde-treated nucleic acids fanconi anemia cells replication-coupled proteolysis dna-protein crosslinks full article pdf human excision nuclease chromosomal damage induced formaldehyde-exposed cells occurs ubiquitin-pcna interacting regulator dna damage avoidance dna adducts caused

Questions {❓}

Atypical progeroid syndrome: an unknown helicase gene defect?
DNA–protein cross-link repair: what do we know now?
What is the DNA repair defect underlying Fanconi anemia?

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