We are analyzing https://link.springer.com/article/10.1007/s11427-015-4925-1.

Title:
Inhibitory leukocyte immunoglobulin-like receptors in cancer development | Science China Life Sciences
Description:
Inhibitory leukocyte immunoglobulin-like receptors (LILRB1-5) signal through immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their intracellular domains and recruit phosphatases protein tyrosine phosphatase, non-receptor type 6 (PTPN6, SHP-1), protein tyrosine phosphatase, non-receptor type 6 (PTPN6, SHP-2), or Src homology 2 domain containing inositol phosphatase (SHIP) to negatively regulate immune cell activation. These receptors are known to play important regulatory roles in immune and neuronal functions. Recent studies demonstrated that several of these receptors are expressed by cancer cells. Importantly, they may directly regulate development, drug resistance, and relapse of cancer, and the activity of cancer stem cells. Although counterintuitive, these findings are consistent with the generally immune-suppressive and thus tumor-promoting roles of the inhibitory receptors in the immune system. This review focuses on the ligands, expression pattern, signaling, and function of LILRB family in the context of cancer development. Because inhibition of the signaling of certain LILRBs directly blocks cancer growth and stimulates immunity that may suppress tumorigenesis, but does not disturb normal development, LILRB signaling pathways may represent ideal targets for treating hematological malignancies and perhaps other tumors.
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Keywords {🔍}

pubmed, article, google, scholar, cas, receptor, cell, cells, central, immunol, inhibitory, receptors, cancer, immunoglobulinlike, zhang, human, ilt, shp, iglike, wang, transcript, leukocyte, expression, phosphatase, activation, signaling, biol, chen, tyrosine, med, suciufoca, lilrb, protein, inhibition, colonna, nat, class, leukemia, liu, development, access, immune, exp, sci, cortesini, open, zheng, tyrosinebased, immunity, myeloid,

Topics {✒️}

gm-csf signal transduction alloantigen specific cd8+cd28-foxp3+ tyrosine-based inhibition motif protein-tyrosine phosphatase shp-1 jaehyup kim & chengcheng zhang fcr-dependent cell activation china life sci shp-1 c-terminal tyrosines myeloid-derived suppressor cells increased g-csf responsiveness negative b-cell selection hla-g1-specific receptor article download pdf neoplastic b-cell growth tyrosine phosphatase shp-1 lyn-mediated shp-1 recruitment shp-1/grb2-dependent mechanism killer-cell inhibitory ligand cd85/leukocyte ig protein tyrosine phosphatase high-affinity fc receptor chronic lymphocytic leukemia pi3k/akt/mtor signalling mediated inhibitory signal ptpn11/shp2 acts open access mhc class binding receptor-1-deficient mice nkcell receptor lir-1 mhc class molecules tumor cell intrinsic olde nordkamp katz hr common inhibitory receptor acute myeloid leukemia angptl2/lilrb2 signaling promotes lilrb signaling pathways leukemia stem cells viral mhc class nonclassical mhc class ilt-2/cd85j/lilrb1 tolerogenic dendritic cells major anchor protein ilt4/b7-h3 natural killer cells acute lymphoblastic leukaemia privacy choices/manage cookies fc gamma riib human basophil activation tumor target cells

Questions {❓}

Immunosuppressive regulatory cells in cancer immunotherapy: restrain or modulate?

Schema {🗺️}

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         headline:Inhibitory leukocyte immunoglobulin-like receptors in cancer development
         description:Inhibitory leukocyte immunoglobulin-like receptors (LILRB1-5) signal through immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their intracellular domains and recruit phosphatases protein tyrosine phosphatase, non-receptor type 6 (PTPN6, SHP-1), protein tyrosine phosphatase, non-receptor type 6 (PTPN6, SHP-2), or Src homology 2 domain containing inositol phosphatase (SHIP) to negatively regulate immune cell activation. These receptors are known to play important regulatory roles in immune and neuronal functions. Recent studies demonstrated that several of these receptors are expressed by cancer cells. Importantly, they may directly regulate development, drug resistance, and relapse of cancer, and the activity of cancer stem cells. Although counterintuitive, these findings are consistent with the generally immune-suppressive and thus tumor-promoting roles of the inhibitory receptors in the immune system. This review focuses on the ligands, expression pattern, signaling, and function of LILRB family in the context of cancer development. Because inhibition of the signaling of certain LILRBs directly blocks cancer growth and stimulates immunity that may suppress tumorigenesis, but does not disturb normal development, LILRB signaling pathways may represent ideal targets for treating hematological malignancies and perhaps other tumors.
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            immunoreceptor tyrosine-based activation motif
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ScholarlyArticle:
      headline:Inhibitory leukocyte immunoglobulin-like receptors in cancer development
      description:Inhibitory leukocyte immunoglobulin-like receptors (LILRB1-5) signal through immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their intracellular domains and recruit phosphatases protein tyrosine phosphatase, non-receptor type 6 (PTPN6, SHP-1), protein tyrosine phosphatase, non-receptor type 6 (PTPN6, SHP-2), or Src homology 2 domain containing inositol phosphatase (SHIP) to negatively regulate immune cell activation. These receptors are known to play important regulatory roles in immune and neuronal functions. Recent studies demonstrated that several of these receptors are expressed by cancer cells. Importantly, they may directly regulate development, drug resistance, and relapse of cancer, and the activity of cancer stem cells. Although counterintuitive, these findings are consistent with the generally immune-suppressive and thus tumor-promoting roles of the inhibitory receptors in the immune system. This review focuses on the ligands, expression pattern, signaling, and function of LILRB family in the context of cancer development. Because inhibition of the signaling of certain LILRBs directly blocks cancer growth and stimulates immunity that may suppress tumorigenesis, but does not disturb normal development, LILRB signaling pathways may represent ideal targets for treating hematological malignancies and perhaps other tumors.
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      dateModified:2015-11-14T00:00:00Z
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      license:https://creativecommons.org/licenses/by/4.0
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         immunoreceptor tyrosine-based inhibitory motifs
         immunoreceptor tyrosine-based activation motif
         leukocyte immunoglobulin-like receptor subfamily B
         immunoglobulin-like transcript
         leukocyte immunoglobulin-like receptor
         phosphatase
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         ITAM
         LILRB
         CD85
         ILT
         LIR
         SHP-1
         SHP-2
         SHIP
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         HLA
         signal transduction
         leukemia
         cancer
         Life Sciences
         general
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      name:Hongqiao International Institute of Medicine, Shanghai Tongren Hospital; Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China
      name:Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China
      name:Hongqiao International Institute of Medicine, Shanghai Tongren Hospital; Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China
      name:Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China
      name:Departments of Physiology and Developmental Biology, University of Texas Southwestern Medical Center, Dallas, USA
      name:Departments of Physiology and Developmental Biology, University of Texas Southwestern Medical Center, Dallas, USA
      name:Departments of Physiology and Developmental Biology, University of Texas Southwestern Medical Center, Dallas, USA
      name:Departments of Physiology and Developmental Biology, University of Texas Southwestern Medical Center, Dallas, USA
      name:Departments of Physiology and Developmental Biology, University of Texas Southwestern Medical Center, Dallas, USA

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