We are analyzing https://link.springer.com/article/10.1007/s11373-008-9247-x.

Title:
Immunotherapy for head and neck cancer | Journal of Biomedical Science
Description:
Head and neck cancer represents a challenging disease. Despite recent treatment advances, which have improved functional outcomes, the long-term survival of head and neck cancer patients has remained unchanged for the past 25 years. One of the goals of adjuvant cancer therapy is to eradicate local regional microscopic and micrometastatic disease with minimal toxicity to surrounding normal cells. In this respect, antigen-specific immunotherapy is an attractive therapeutic approach. With the advances in molecular genetics and fundamental immunology, antigen-specific immunotherapy is being actively explored using DNA, bacterial vector, viral vector, peptide, protein, dendritic cell, and tumor-cell based vaccines. Early phase clinical trials have demonstrated the safety and feasibility of these novel therapies and the emphasis is now shifting towards the development of strategies, which can increase the potency of these vaccines. As the field of immunotherapy matures and as our understanding of the complex interaction between tumor and host develops, we get closer to realizing the potential of immunotherapy as an adjunctive method to control head and neck cancer and improve long-term survival in this patient population.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

google, scholar, pubmed, cas, cancer, neck, head, human, cell, res, oncol, dna, gene, vaccines, papillomavirus, vaccine, clin, factor, immunotherapy, growth, patients, carcinoma, hung, squamous, receptor, cells, tumor, immunol, van, antigen, hpv, tumors, ther, article, phase, clinical, encoding, antitumor, therapeutic, expression, kim, pai, treatment, advanced, rev, chen, virus, cervical, study, cetuximab,

Topics {✒️}

granulocyte-macrophage colony-stimulating factor monoclonal antibody h-r3 specific anti-tumor immunotherapy ctl-mediated killing idiotype-cytokine fusion proteins anti-tumor effects generated tumor-cell based vaccines allogenic antibody-mediated identification month download article/chapter epigallocatechin-3-gallate enhances cd8+ t-cell immunity potent tumour regression activating rho-family gtpases neck squamous-cell carcinomas human papillomavirus vaccines anti-tumour activity adenovirus e1-induced tumors van den eynde plasmid-encoded flt-3 ligand dna vaccine encoding intracellular targeting strategies autologous tumor-infiltrating lymphocytes small-cell lung cancer anti-tumor activity anti-tumor effects e7 protein delivered cell line recognizing improve long-term survival prime-boost vaccination strategy oncogenic human papillomavirus e1a-specific cytotoxic tyrosine kinase 3-ligand advanced epithelial-derived cancer antigen-specific immunotherapy lymphocyte molecules cd28 wild-type p53 antigen-specific agents anti-tumor immunity plasmid dna vaccines enhances vaccine potency human papilloma vaccines papilloma high-grade lesions human papillomavirus infection de la garza squamous cell carcinomas van der bruggen prime/boost immunotherapy achieving selective killing dna vaccine administered b7-transfected melanoma cells

Questions {❓}

Balz V, Scheckenbach K, Gotte K, Bockmuhl U, Petersen I, Bier H (2003) Is the p53 inactivation frequency in squamous cell carcinomas of the head and neck underestimated?
Roden R, Wu TC (2006) How will HPV vaccines affect cervical cancer?

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