We are analyzing https://link.springer.com/article/10.1007/s11373-005-9063-5.

Title:
The tumor suppressor DAP-kinase links cell adhesion and cytoskeleton reorganization to cell death regulation | Journal of Biomedical Science
Description:
Death-associated protein (DAP)-kinase, an actin-cytoskeleton localized serine/threonine kinase, functions as a novel tumor suppressor and participates in a wide variety of cell death systems. Recent studies indicate that DAP-kinase elicits a potent cytoskeletal reorganization effect and is capable of modulating integrin inside-out signaling. Using this understanding of DAP-kinase protein function as a framework, we discuss the functional mechanisms of this kinase in regulating death-associated morphological and signaling events. Furthermore, a potential role of DAP-kinase to be a drug target is also discussed.
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Keywords {🔍}

google, scholar, pubmed, cas, article, cell, kinase, cancer, dapkinase, protein, biol, deathassociated, kimchi, death, apoptosis, chen, res, hypermethylation, promoter, dap, gene, expression, tumor, regulation, role, cohen, methylation, science, suppressor, kuo, integrin, dapk, genes, privacy, cookies, function, journal, wang, signaling, activity, carcinoma, oncogene, clin, anoikis, content, publish, search, download, feinstein, embo,

Topics {✒️}

won-jing wang & jean-cheng kuo p19arf/p53-mediated apoptotic checkpoint involve myosin-ii phosphorylation brain hypoxic-ischemic injury tgf-beta induces apoptosis adhesion-mediated signaling dapk–erk interaction promote dap-kinase induces apoptosis dap-kinase-mediated morphological dap-kinase cpg island serine/threonine kinase dap kinase links cell death-inducing functions dap-kinase protein function privacy choices/manage cookies tumor suppressor gene related subjects bidirectional signals transduced suppress oncogenic transformation fas-induced apoptosis trail-induced apoptosis ceramide- induced apoptosis ceramide-induced apoptosis ruey-hwa chen b-cell malignancies smad-mediated expression programmed cell death kinase cpg island dap kinase activates integrin beta tails final common step protein-kinase gene tyrosine kinase-dependent key regulatory element cpg island methylation bak-mcl1 complex national taiwan university protein kinase mrnas ca2+/calmodulin-dependent gene promoter methylation dap-kinase elicits dap kinase family modulating integrin inside european economic area pro-apoptotic proteins invasive pituitary tumours cultured hippocampal neurons atg7-beclin 1 program squamous cell cancer pro-apoptotic function

Questions {❓}

, To die or not to die: how does p53 decide?

Schema {🗺️}

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         headline:The tumor suppressor DAP-kinase links cell adhesion and cytoskeleton reorganization to cell death regulation
         description:Death-associated protein (DAP)-kinase, an actin-cytoskeleton localized serine/threonine kinase, functions as a novel tumor suppressor and participates in a wide variety of cell death systems. Recent studies indicate that DAP-kinase elicits a potent cytoskeletal reorganization effect and is capable of modulating integrin inside-out signaling. Using this understanding of DAP-kinase protein function as a framework, we discuss the functional mechanisms of this kinase in regulating death-associated morphological and signaling events. Furthermore, a potential role of DAP-kinase to be a drug target is also discussed.
         datePublished:2006-02-03T00:00:00Z
         dateModified:2006-02-03T00:00:00Z
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      headline:The tumor suppressor DAP-kinase links cell adhesion and cytoskeleton reorganization to cell death regulation
      description:Death-associated protein (DAP)-kinase, an actin-cytoskeleton localized serine/threonine kinase, functions as a novel tumor suppressor and participates in a wide variety of cell death systems. Recent studies indicate that DAP-kinase elicits a potent cytoskeletal reorganization effect and is capable of modulating integrin inside-out signaling. Using this understanding of DAP-kinase protein function as a framework, we discuss the functional mechanisms of this kinase in regulating death-associated morphological and signaling events. Furthermore, a potential role of DAP-kinase to be a drug target is also discussed.
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      name:Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
      name:Institute of Molecular Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan

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