We are analyzing https://link.springer.com/article/10.1007/s11357-019-00077-z.

Title:
Lipotoxicity, aging, and muscle contractility: does fiber type matter? | GeroScience
Description:
Sarcopenia is a universal characteristic of the aging process and is often accompanied by increases in whole-body adiposity. These changes in body composition have important clinical implications, given that loss of muscle and gain of fat mass are both significantly and independently associated with declining physical performance as well as an increased risk for disability, hospitalizations, and mortality in older individuals. This increased fat mass is not exclusively stored in adipose depots but may become deposited in non-adipose tissues, such as skeletal muscle, when the oxidative capacity of the adipose tissue itself is exceeded. The redistributed adipose tissue is thought to exert detrimental local effects on the muscle environment given the close proximity. Thus, sarcopenia observed with aging may be better defined in the context of loss of muscle quality rather than loss of muscle quantity per se. In this perspective, we briefly review the age-related physiological changes in cellularity, secretory profiles, and inflammatory status of adipose tissue which drive lipotoxicity (spillover) of skeletal muscle and then provide evidence of how this may affect specific fiber type contractility. We focus on biological contributors (cellular machinery) to contractility for which there is some evidence of vulnerability to lipid stress distinguishing between fiber types.
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28 years and 1 months (reg. 1997-05-29).

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Keywords {🔍}

pubmed, article, google, scholar, muscle, cas, skeletal, central, aging, cell, physiol, fiber, adipose, tissue, cells, function, fat, insulin, type, sarcopenia, obesity, tchkonia, sci, biol, cellular, human, senescence, content, agerelated, lipid, van, resistance, nutr, med, kirkland, clin, lipotoxicity, composition, mass, rats, metab, justice, body, access, contractile, front, diabetes, senescent, mice, metabolic,

Topics {✒️}

5-diiodo-l-thyronine affects structural slow-twitch fiber proportion month download article/chapter fiber-type-specific sensitivities fiber type-specific immunostaining triacylglycerol-accumulated fiber type fiber type-dependent manner age-related chronic diseases high-fat diet fiber type-specific differences low fat-free mass type-identified diaphragm fibers tumor necrosis factor-alpha receptor 4/nf-kappab pathway age-related muscle atrophy body weight-dependent troponin aging-related muscle dysfunctions dietary fat source obesity-linked insulin resistance article geroscience aims lipid-induced insulin resistance dietary fat content full article pdf tnf-induced activation review article published fiber type composition impaired contractile force ceramide-induced lipotoxicity fiber type matter privacy choices/manage cookies human skeletal muscle high body fatness total intramuscular fat fat cell progenitors verdijk lb muscle-specific adaptations skeletal muscle regeneration skeletal muscle mass skeletal muscle correlates skeletal muscle myotubes human muscle fibres increased fat mass glycolytic fiber phenotype lipid stress distinguishing adipose tissue dysfunction van den berg idiopathic pulmonary fibrosis additional information publisher linking age-related age-related remodeling

Questions {❓}

Lipotoxicity, aging, and muscle contractility: does fiber type matter?
Lipotoxicity, aging, and muscle contractility: does fiber type matter?
Newman AB (2015) Is the onset of obesity the same as aging?

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         description:Sarcopenia is a universal characteristic of the aging process and is often accompanied by increases in whole-body adiposity. These changes in body composition have important clinical implications, given that loss of muscle and gain of fat mass are both significantly and independently associated with declining physical performance as well as an increased risk for disability, hospitalizations, and mortality in older individuals. This increased fat mass is not exclusively stored in adipose depots but may become deposited in non-adipose tissues, such as skeletal muscle, when the oxidative capacity of the adipose tissue itself is exceeded. The redistributed adipose tissue is thought to exert detrimental local effects on the muscle environment given the close proximity. Thus, sarcopenia observed with aging may be better defined in the context of loss of muscle quality rather than loss of muscle quantity per se. In this perspective, we briefly review the age-related physiological changes in cellularity, secretory profiles, and inflammatory status of adipose tissue which drive lipotoxicity (spillover) of skeletal muscle and then provide evidence of how this may affect specific fiber type contractility. We focus on biological contributors (cellular machinery) to contractility for which there is some evidence of vulnerability to lipid stress distinguishing between fiber types.
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