We are analyzing https://link.springer.com/article/10.1007/s11357-017-9970-1.

Title:
Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells | GeroScience
Description:
Apigenin (4′,5,7,-trihydroxyflavone) is a flavonoid found in certain herbs, fruits, and vegetables. Apigenin can attenuate inflammation, which is associated with many chronic diseases of aging. Senescent cells—stressed cells that accumulate with age in mammals—display a pro-inflammatory senescence-associated secretory phenotype (SASP) that can drive or exacerbate several age-related pathologies, including cancer. Flavonoids, including apigenin, were recently shown to reduce the SASP of a human fibroblast strain induced to senesce by bleomycin. Here, we confirm that apigenin suppresses the SASP in three human fibroblast strains induced to senesce by ionizing radiation, constitutive MAPK (mitogen-activated protein kinase) signaling, oncogenic RAS, or replicative exhaustion. Apigenin suppressed the SASP in part by suppressing IL-1α signaling through IRAK1 and IRAK4, p38-MAPK, and NF-κB. Apigenin was particularly potent at suppressing the expression and secretion of CXCL10 (IP10), a newly identified SASP factor. Further, apigenin-mediated suppression of the SASP substantially reduced the aggressive phenotype of human breast cancer cells, as determined by cell proliferation, extracellular matrix invasion, and epithelial-mesenchymal transition. Our results support the idea that apigenin is a promising natural product for reducing the impact of senescent cells on age-related diseases such as cancer.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {📚}

Education
Health & Fitness
Science

Content Management System {📝}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {📈}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,642,828 visitors per month in the current month.

check SE Ranking
check Ahrefs
check Similarweb
check Ubersuggest
check Semrush

How Does Link.springer.com Make Money? {💸}

We're unsure if the website is profiting.

Some websites aren't about earning revenue; they're built to connect communities or raise awareness. There are numerous motivations behind creating websites. This might be one of them. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {🔍}

pubmed, article, google, scholar, cas, apigenin, cells, campisi, cell, central, senescenceassociated, senescent, cancer, secretory, flavonoids, phenotype, desprez, sasp, human, fibroblasts, aging, levels, research, inflammation, induced, expression, secretion, suppression, senescence, nature, biol, pdf, privacy, cookies, content, effects, senesce, nfκb, related, cellular, patil, freund, inflammatory, publish, search, geroscience, suppresses, breast, judith, access,

Topics {✒️}

mitogen-activated protein kinase phosphatidylinositol 3-kinase/akt-dependent pathway month download article/chapter nf-κb reporter activation nf-κb activation pathways extracellular matrix invasion il6/il-8 cytokine network epithelial-mesenchymal transition induced cell surface il-1α inactivating nf-kappab proinflammatory nf-kappab senescent cells—stressed cells p53 tumor suppressor recombinant il-1a remi-martin laberge article geroscience aims suppressing il-1α signaling hif-1α protein full article pdf sens research foundation human cellular senescence breast cancer cells cell proliferation privacy choices/manage cookies epithelial-mesenchymal transition matrix-degrading proteases mouse cells dependent dmso-treated ns cells nf-κb selective growth-inhibitory il-1a nf-kb p65 apigenin inhibits release decreasing caspase-3 activation coppé jp structurally related flavonoids age-related pathologies cell-cycle deregulatory cell cycle progression inflammatory cytokine secretion senescent hca2 cells secretory phenotype formation switches immune response cancer cell apoptosis anti-inflammatory activity senescent bj fibroblasts european economic area casaclang versoza gc van deursen jm pereira-smith om

Schema {🗺️}

WebPage:
      mainEntity:
         headline:Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells
         description:Apigenin (4′,5,7,-trihydroxyflavone) is a flavonoid found in certain herbs, fruits, and vegetables. Apigenin can attenuate inflammation, which is associated with many chronic diseases of aging. Senescent cells—stressed cells that accumulate with age in mammals—display a pro-inflammatory senescence-associated secretory phenotype (SASP) that can drive or exacerbate several age-related pathologies, including cancer. Flavonoids, including apigenin, were recently shown to reduce the SASP of a human fibroblast strain induced to senesce by bleomycin. Here, we confirm that apigenin suppresses the SASP in three human fibroblast strains induced to senesce by ionizing radiation, constitutive MAPK (mitogen-activated protein kinase) signaling, oncogenic RAS, or replicative exhaustion. Apigenin suppressed the SASP in part by suppressing IL-1α signaling through IRAK1 and IRAK4, p38-MAPK, and NF-κB. Apigenin was particularly potent at suppressing the expression and secretion of CXCL10 (IP10), a newly identified SASP factor. Further, apigenin-mediated suppression of the SASP substantially reduced the aggressive phenotype of human breast cancer cells, as determined by cell proliferation, extracellular matrix invasion, and epithelial-mesenchymal transition. Our results support the idea that apigenin is a promising natural product for reducing the impact of senescent cells on age-related diseases such as cancer.
         datePublished:2017-04-04T00:00:00Z
         dateModified:2017-04-04T00:00:00Z
         pageStart:161
         pageEnd:173
         sameAs:https://doi.org/10.1007/s11357-017-9970-1
         keywords:
            Flavonoids
            Human fibroblasts
            Proliferation
            Invasion
            IL-6
            IL-1A
            IRAK1/4
            NF-κB
            Cell Biology
            Geriatrics/Gerontology
            Molecular Medicine
         image:
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-017-9970-1/MediaObjects/11357_2017_9970_Fig1_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-017-9970-1/MediaObjects/11357_2017_9970_Fig2_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-017-9970-1/MediaObjects/11357_2017_9970_Fig3_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-017-9970-1/MediaObjects/11357_2017_9970_Fig4_HTML.gif
            https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-017-9970-1/MediaObjects/11357_2017_9970_Fig5_HTML.gif
         isPartOf:
            name:GeroScience
            issn:
               2509-2723
               2509-2715
            volumeNumber:39
            type:
               Periodical
               PublicationVolume
         publisher:
            name:Springer International Publishing
            logo:
               url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
               type:ImageObject
            type:Organization
         author:
               name:Kevin M. Perrott
               affiliation:
                     name:Buck Institute for Research on Aging
                     address:
                        name:Buck Institute for Research on Aging, Novato, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Christopher D. Wiley
               affiliation:
                     name:Buck Institute for Research on Aging
                     address:
                        name:Buck Institute for Research on Aging, Novato, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Pierre-Yves Desprez
               affiliation:
                     name:California Pacific Medical Center Research Institute
                     address:
                        name:California Pacific Medical Center Research Institute, San Francisco, USA
                        type:PostalAddress
                     type:Organization
               type:Person
               name:Judith Campisi
               affiliation:
                     name:Buck Institute for Research on Aging
                     address:
                        name:Buck Institute for Research on Aging, Novato, USA
                        type:PostalAddress
                     type:Organization
                     name:Lawrence Berkeley National Laboratory
                     address:
                        name:Lawrence Berkeley National Laboratory, Berkeley, USA
                        type:PostalAddress
                     type:Organization
               email:[email protected]
               type:Person
         isAccessibleForFree:
         hasPart:
            isAccessibleForFree:
            cssSelector:.main-content
            type:WebPageElement
         type:ScholarlyArticle
      context:https://schema.org
ScholarlyArticle:
      headline:Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells
      description:Apigenin (4′,5,7,-trihydroxyflavone) is a flavonoid found in certain herbs, fruits, and vegetables. Apigenin can attenuate inflammation, which is associated with many chronic diseases of aging. Senescent cells—stressed cells that accumulate with age in mammals—display a pro-inflammatory senescence-associated secretory phenotype (SASP) that can drive or exacerbate several age-related pathologies, including cancer. Flavonoids, including apigenin, were recently shown to reduce the SASP of a human fibroblast strain induced to senesce by bleomycin. Here, we confirm that apigenin suppresses the SASP in three human fibroblast strains induced to senesce by ionizing radiation, constitutive MAPK (mitogen-activated protein kinase) signaling, oncogenic RAS, or replicative exhaustion. Apigenin suppressed the SASP in part by suppressing IL-1α signaling through IRAK1 and IRAK4, p38-MAPK, and NF-κB. Apigenin was particularly potent at suppressing the expression and secretion of CXCL10 (IP10), a newly identified SASP factor. Further, apigenin-mediated suppression of the SASP substantially reduced the aggressive phenotype of human breast cancer cells, as determined by cell proliferation, extracellular matrix invasion, and epithelial-mesenchymal transition. Our results support the idea that apigenin is a promising natural product for reducing the impact of senescent cells on age-related diseases such as cancer.
      datePublished:2017-04-04T00:00:00Z
      dateModified:2017-04-04T00:00:00Z
      pageStart:161
      pageEnd:173
      sameAs:https://doi.org/10.1007/s11357-017-9970-1
      keywords:
         Flavonoids
         Human fibroblasts
         Proliferation
         Invasion
         IL-6
         IL-1A
         IRAK1/4
         NF-κB
         Cell Biology
         Geriatrics/Gerontology
         Molecular Medicine
      image:
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-017-9970-1/MediaObjects/11357_2017_9970_Fig1_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-017-9970-1/MediaObjects/11357_2017_9970_Fig2_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-017-9970-1/MediaObjects/11357_2017_9970_Fig3_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-017-9970-1/MediaObjects/11357_2017_9970_Fig4_HTML.gif
         https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11357-017-9970-1/MediaObjects/11357_2017_9970_Fig5_HTML.gif
      isPartOf:
         name:GeroScience
         issn:
            2509-2723
            2509-2715
         volumeNumber:39
         type:
            Periodical
            PublicationVolume
      publisher:
         name:Springer International Publishing
         logo:
            url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
            type:ImageObject
         type:Organization
      author:
            name:Kevin M. Perrott
            affiliation:
                  name:Buck Institute for Research on Aging
                  address:
                     name:Buck Institute for Research on Aging, Novato, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Christopher D. Wiley
            affiliation:
                  name:Buck Institute for Research on Aging
                  address:
                     name:Buck Institute for Research on Aging, Novato, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Pierre-Yves Desprez
            affiliation:
                  name:California Pacific Medical Center Research Institute
                  address:
                     name:California Pacific Medical Center Research Institute, San Francisco, USA
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Judith Campisi
            affiliation:
                  name:Buck Institute for Research on Aging
                  address:
                     name:Buck Institute for Research on Aging, Novato, USA
                     type:PostalAddress
                  type:Organization
                  name:Lawrence Berkeley National Laboratory
                  address:
                     name:Lawrence Berkeley National Laboratory, Berkeley, USA
                     type:PostalAddress
                  type:Organization
            email:[email protected]
            type:Person
      isAccessibleForFree:
      hasPart:
         isAccessibleForFree:
         cssSelector:.main-content
         type:WebPageElement
["Periodical","PublicationVolume"]:
      name:GeroScience
      issn:
         2509-2723
         2509-2715
      volumeNumber:39
Organization:
      name:Springer International Publishing
      logo:
         url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
         type:ImageObject
      name:Buck Institute for Research on Aging
      address:
         name:Buck Institute for Research on Aging, Novato, USA
         type:PostalAddress
      name:Buck Institute for Research on Aging
      address:
         name:Buck Institute for Research on Aging, Novato, USA
         type:PostalAddress
      name:California Pacific Medical Center Research Institute
      address:
         name:California Pacific Medical Center Research Institute, San Francisco, USA
         type:PostalAddress
      name:Buck Institute for Research on Aging
      address:
         name:Buck Institute for Research on Aging, Novato, USA
         type:PostalAddress
      name:Lawrence Berkeley National Laboratory
      address:
         name:Lawrence Berkeley National Laboratory, Berkeley, USA
         type:PostalAddress
ImageObject:
      url:https://www.springernature.com/app-sn/public/images/logo-springernature.png
Person:
      name:Kevin M. Perrott
      affiliation:
            name:Buck Institute for Research on Aging
            address:
               name:Buck Institute for Research on Aging, Novato, USA
               type:PostalAddress
            type:Organization
      name:Christopher D. Wiley
      affiliation:
            name:Buck Institute for Research on Aging
            address:
               name:Buck Institute for Research on Aging, Novato, USA
               type:PostalAddress
            type:Organization
      name:Pierre-Yves Desprez
      affiliation:
            name:California Pacific Medical Center Research Institute
            address:
               name:California Pacific Medical Center Research Institute, San Francisco, USA
               type:PostalAddress
            type:Organization
      name:Judith Campisi
      affiliation:
            name:Buck Institute for Research on Aging
            address:
               name:Buck Institute for Research on Aging, Novato, USA
               type:PostalAddress
            type:Organization
            name:Lawrence Berkeley National Laboratory
            address:
               name:Lawrence Berkeley National Laboratory, Berkeley, USA
               type:PostalAddress
            type:Organization
      email:[email protected]
PostalAddress:
      name:Buck Institute for Research on Aging, Novato, USA
      name:Buck Institute for Research on Aging, Novato, USA
      name:California Pacific Medical Center Research Institute, San Francisco, USA
      name:Buck Institute for Research on Aging, Novato, USA
      name:Lawrence Berkeley National Laboratory, Berkeley, USA
WebPageElement:
      isAccessibleForFree:
      cssSelector:.main-content

External Links {🔗}(170)

Analytics and Tracking {📊}

Google Tag Manager

Libraries {📚}

Clipboard.js
Prism.js

CDN Services {📦}

Crossref

3.87s.

LINK . SPRINGER . COM {}