We are analyzing https://link.springer.com/article/10.1007/s11357-008-9075-y.

Title:
Cellular senescence, ageing and disease | GeroScience
Description:
Cellular senescence is the irreversible growth arrest of individual mitotic cells, which as a consequence display a radically altered phenotype that is thought to impair tissue function and predispose tissues to disease development and/or progression as they gradually accumulate. However, in the past, research into mechanisms of ageing has commonly been researched and treated separately from disease development. This may partly be due to the lack of understanding concerning mechanisms of ageing and the difficulty in implementing what was known into models of disease development. Only in the last 10 years, with increasing knowledge of the senescent phenotype and the ability to detect senescent cells in human tissues, have biologists been able to investigate the relationship between cellular senescence and disease. This review therefore brings together and discusses recent findings which suggest that cellular senescence does contribute to ageing and the development/progression of disease.
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Keywords {🔍}

google, scholar, article, pubmed, cas, cell, senescence, cells, human, ageing, aging, cellular, senescent, cancer, disease, res, biol, fibroblasts, replicative, endothelial, sci, stem, inflammation, acad, campisi, burton, growth, mechanisms, expression, role, mech, dev, privacy, cookies, content, age, phenotype, usa, publish, research, search, tissue, access, death, epithelial, contributes, vascular, muscle, nitric, oxide,

Topics {✒️}

month download article/chapter p53-mediated icam-1 expression p53-dependent icam-1 overexpression full article pdf article age aims renewal factors contributes alveolar epithelial cells privacy choices/manage cookies rb/p16ink4a inactivation single-strand breaks microvascular endothelial cells h2o2-induced senescent senescent human fibroblasts endothelial cell senescence detect senescent cells article burton double-edged sword epidermal growth factor senescent large-vessel accelerated cellular senescence stem cells age impaired cell growth age-related disease primary human fibroblasts irreversible growth arrest stem cell exhaustion stem cell movement radically altered phenotype individual mitotic cells programmed cell death dna hyper-replication bone resorption genes oncogene-induced senescence normal human fibroblasts european economic area scope submit manuscript discusses recent findings radovic-moreno af benign prostatic hyperplasia polycomb protein bmi-1 degenerate intervertebral discs intervertebral disc degeneration emphysema show markers anchors cytoplasmic p53 collagen gels declines age-dependent decline stem cell niche cell kinetic analysis dendritic cell system cell replicative senescence

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