We are analyzing https://link.springer.com/article/10.1007/s11307-015-0902-0.

Title:
Magnetic Targeting and Delivery of Drug-Loaded SWCNTs Theranostic Nanoprobes to Lung Metastasis in Breast Cancer Animal Model: Noninvasive Monitoring Using Magnetic Resonance Imaging | Molecular Imaging and Biology
Description:
Purpose In this study, we aimed to develop novel therapeutic and diagnostic approaches by improving the targeting of doxorubicin-loaded single-walled carbon nanotubes (SWCNTs) to metastatic regions, and monitor their preferential homing and enhanced therapeutic effect using noninvasive free-breathing magnetic resonance imaging (MRI) and bioluminescence imaging. Procedures High-energy flexible magnets were specifically positioned over the metastatic tumor sites in the lungs. SWCNTs biodistribution, tumor progression, and subsequent treatment efficiency were assessed following administration of the magnetically attracted doxorubicin-loaded anti-CD105 conjugated nanocarriers. Results The use of high-energy magnets offered improved theranostic effect of doxorubicin-loaded nanocarriers, by magnetically targeting them towards metastatic tumor sites in the lungs. MRI allowed sensitive monitoring of nanocarriers biodistribution in the abdominal organs, their preferential homing towards the metastatic sites, and their enhanced therapeutic effect. Conclusions Combination of noninvasive MRI to localize sensitively the tumor sites, with specific positioning of magnets that can enhance the magnetic targeting of nanocarriers, allowed increasing the treatment efficiency.
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Keywords {🔍}

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Topics {✒️}

month download article/chapter magnetic resonance imaging carbon nanotube-polymer interactions anti-endoglin monoclonal antibodies article molecular imaging propelling targeted magneto-nanobots lps-induced animal model project number a-t-32-81 doxorubicin-loaded nanocarriers achraf al faraj full article pdf breast cancer statistics emerging drug carrier sensitive imaging biomarker treating metastatic cancer enhanced therapeutic effect preferential magnetic targeting vivo bioluminescent imaging cellular imaging lab drug delivery potential drug carriers asma sultana shaik privacy choices/manage cookies breast cancer metastasis called theranostic system imagable 4t1 model targeting cancer cells modern cancer biology check access related subjects instant access magnetic nanoparticles metastatic tumor sites drug deliv 2014 bmc cancer 8 targeting tumor vasculature carbon nanotubes magnetic targeting lung metastasis subsequent treatment efficiency european economic area magnetically targeting soil’ hypothesis revisited sousa lobo jm bronchial remodeling assessment king abdulaziz city king saud university ethics declarations conflict al-suwayeh sa conditions privacy policy

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