We are analyzing https://link.springer.com/article/10.1007/s11307-006-0064-1.

Title:
Optimization of Whole-Body Positron Emission Tomography Imaging by Using Delayed 2-Deoxy-2-[F-18]fluoro-d-glucose Injection Following I.V. Insulin in Diabetic Patients | Molecular Imaging and Biology
Description:
Purpose High blood glucose levels may decrease the sensitivity of 2-deoxy-2-[F-18]fluoro-d-glucose (FDG)-positron emission tomography (PET). The goal of this study was to assess whether intravenous (i.v.) insulin followed by FDG injection 60 minutes later could decrease the blood glucose level of hyperglycemic patients without altering muscular, liver, or lung FDG uptake. Methods We evaluated 53 diabetic patients with a fasting glycemia higher than 7.0 mmol/l. The control group consisted of 53 nondiabetic patients with a normal fasting glycemia. Sixty minutes before FDG injection, all diabetic patients received up to two intravenous bolus of insulin. Regions of interest were drawn over the lungs, heart, liver, skeletal muscles, and over the most active lung nodule, if present, to calculate a standardized uptake value (SUV) normalized to the lean body weight. Results After one or two boluses of insulin (mean 3.4 units), 39 diabetic patients decreased their blood glucose level from 9.4 ± 1.8 to 6.1 ± 1.3 mmol/l. In 14 patients, two doses of insulin (mean 4.5 ± 2.3 units) were not sufficient, but managed to decrease the blood glucose level from 10.6 ± 2.1 to 9.1 ± 2.1 mmol/l. There was no significant difference for the SUV calculated on the lung, liver, heart, and skeletal muscles. No differences were noted in lung tumor uptake in patients who received insulin compared to the control group. Conclusions With a sufficient waiting period between the insulin and FDG injections, an i.v. bolus of insulin makes it possible to effectively decrease glycemia of diabetic patients without increasing muscular FDG uptake.
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article, pubmed, google, scholar, insulin, cas, patients, glucose, uptake, fdg, imaging, lung, diabetes, cancer, nucl, med, diabetic, blood, access, privacy, cookies, content, research, fdgpet, sherbrooke, publish, search, injection, decrease, study, level, liver, open, influence, clin, data, information, log, journal, molecular, wholebody, positron, emission, tomography, deoxyffluorodglucose, turcotte, leblanc, carpentier, françois, bénard,

Topics {✒️}

delayed 2-deoxy-2-[f-18]fluoro-d-glucose injection 2-deoxy-2-[f-18]fluoro-d-glucose 2-[f-18]-fluoro-2-deoxy-d-glucose 2-[f-18]fluoro-2-deoxy-d-glucose month download article/chapter françois bénard md type 1 diabetes michel leblanc md body fdg-pet imaging article molecular imaging clinical research center low-dose intravenous insulin positron emission tomography blood glucose levels plasma glucose levels diabetes mellitus influence full article pdf privacy choices/manage cookies related subjects blood glucose level blood glucose concentration fdg-pet imaging lean body weight lean body mass article turcotte diabetes affect [ normal tissue accumulation european economic area fasting glycemia higher experimental malignant tumours received insulin compared conditions privacy policy normal fasting glycemia active lung nodule experimental mammary carcinoma diabetic patients received lung fdg uptake pet/ct accepting optional cookies control group consisted sufficient waiting period check access instant access fdg injection fluorine-18-fluorodeoxyglucose uptake main content log primary lung cancer effectively decrease glycemia journal finder publish author correspondence

Questions {❓}

(2005) Does diabetes mellitus influence the efficacy of FDG-PET in the diagnosis of cervical cancer?
Gorenberg M, Hallett WA, O’Doherty MJ (2002) Does diabetes affect [(18)F]FDG standardised uptake values in lung cancer?

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