We are analyzing https://link.springer.com/article/10.1007/s11248-024-00404-x.

Title:
Next-generation CRISPR technology for genome, epigenome and mitochondrial editing | Transgenic Research
Description:
The application of rapidly growing CRISPR toolboxes and methods has great potential to transform biomedical research. Here, we provide a snapshot of up-to-date CRISPR toolboxes, then critically discuss the promises and hurdles associated with CRISPR-based nuclear genome editing, epigenome editing, and mitochondrial editing. The technical challenges and key solutions to realize epigenome editing in vivo, in vivo base editing and prime editing, mitochondrial editing in complex tissues and animals, and CRISPR-associated transposases and integrases in targeted genomic integration of very large DNA payloads are discussed. Lastly, we discuss the latest situation of the CRISPR/Cas9 clinical trials and provide perspectives on CRISPR-based gene therapy. Apart from technical shortcomings, ethical and societal considerations for CRISPR applications in human therapeutics and research are extensively highlighted. Graphical Abstract
Website Age:
28 years and 1 months (reg. 1997-05-29).

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Education
Business & Finance
Science

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Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

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What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month

Based on our best estimate, this website will receive around 7,643,078 visitors per month in the current month.

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The income method remains a mystery to us.

Not all websites are made for profit; some exist to inform or educate users. Or any other reason why people make websites. And this might be the case. Link.springer.com might be cashing in, but we can't detect the method they're using.

Keywords {🔍}

pubmed, article, google, scholar, cas, central, nat, editing, zhang, liu, wang, httpsdoiorgs, genome, cell, chen, dna, crisprcas, crispr, gene, nature, biotechnol, kim, base, human, commun, engineering, gao, biol, httpsdoiorgjcell, cells, mitochondrial, yang, targeting, science, lee, huang, engineered, efficient, editors, res, zhou, rna, httpsdoiorgnature, nucleic, targeted, acids, mol, zhao, sun, vivo,

Topics {✒️}

transposon-encoded crispr-cas system crispr-cas suntag-directed dnmt3a quasi-dimeric zinc-finger nuclease homology-directed-repair-independent mechanism synthetic crispr-cas9-based hdac month download article/chapter base-editing-induced nonsense mutations cas9/grna-mediated genome editing high-fidelity crispr-cas9 nucleases crispr/cas9-mediated base editors chimeric dcas9-dnmt3a-dnmt3l methyltransferase genome-scale crispr-mediated control optimized crispr/cas system crispr/cas9-mediated gene editing c2c1 crispr-cas endonuclease crispr-cas gene editing crispr/cas clinical translation double-stranded dna cleavage crispr-cas9-based transcription factors trans-encoded small rna translating crispr-cas therapeutics crispr-cas7-11 effector complex single rna-guided endonuclease adenine deaminase tada-8e rad51 dna-binding domain dcas9-transposase fusion protein dna donor-binding domain xcas9-derived base editors engineered crispr-cas9 nucleases strand-preferred base editing cpf1-cytidine deaminase fusion cas9 rna-guided endonuclease crispr-based genome editing cas12i rna-guided endonuclease crispr/cas systems crispr-cas systems exonuclease-enhanced prime editors crispr-based epigenome editing rna-guided crispr cas9 engineered uracil-dna glycosylase rna-guided rna cleavage rna-guided genome editors halpin-healy ts article lau double-strand dna cleavage locus-specific 3d chromatin high-precision base editors tissue-specific mrna delivery pam-flexible cas9 variants study chromosome-specific aneuploidy

Questions {❓}

Dahiya N, Garg S (2018) Three-parent baby: Is it ethical ?
Imbriano C, Belluti S (2022) Histone marks-dependent effect on alternative splicing: new perspectives for targeted splicing modulation in cancer?
Knoppers BM, Kleiderman E (2019) Heritable genome editing: who speaks for “future” children?
Ledford H (2019) CRISPR babies: when will the world be ready?

Schema {🗺️}

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