We are analyzing https://link.springer.com/article/10.1007/s11154-013-9252-x.

Title:
Metabolically healthy obesity: Definitions, determinants and clinical implications | Reviews in Endocrine and Metabolic Disorders
Description:
Obesity is associated with increased risk of developing metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) leading to higher all-cause mortality. However accumulating evidence suggests that not all obese subjects are at increased cardiometabolic risk and that the “metabolically healthy obese” (MHO) phenotype may exist in the absence of metabolic abnormalities. Despite the knowledge of the existence of obese metabolic phenotypes for some time now there is no standard set of criteria to define metabolic health, thus impacting on the accurate estimation of the prevalence of the MHO phenotype and making comparability between studies difficult. Furthermore prospective studies tracking the development of cardiometabolic disease and mortality in MHO have also produced conflicting results. Limited data regards the determinants of the MHO phenotype exist, particularly in relation to dietary and lifestyle behaviours. In light of the current obesity epidemic it is clear that current “one size fits all” approaches to tackle obesity are largely unsuccessful. Whether dietary, lifestyle and/or therapeutic interventions based on stratification of obese individuals according to their metabolic health phenotype are more effective remains to be seen, with limited and conflicting data available so far. This review will present the current state of the art including the epidemiology of MHO and its definitions, what factors may be important in determining metabolic health status and finally, some potential implications of the MHO phenotype in the context of obesity diagnosis, interventions and treatment.
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Questions {❓}

(2013) Metabolically healthy but obese, a matter of time?
An unsuitable and degraded diet?
Are metabolically normal but obese individuals at lower risk for all-cause mortality?
Are natural killer cells protecting the metabolically healthy obese patient?
Can we identify metabolically healthy but obese individuals (MHO)?
Commentary: Current perspectives on obesity and health: Black and white, or shades of grey?
Diabetes mellitus: A “thrifty” genotype rendered detrimental by “progress”?
Do obese but metabolically normal women differ in intra-abdominal fat and physical activity levels from those with the expected metabolic abnormalities?
Does inflammation determine whether obesity is metabolically healthy or unhealthy?
Hinnouho GM, Czernichow S, Dugravot A, Batty GD, Kivimaki M, Singh-Manoux A (2013) Metabolically healthy obesity and risk of mortality: does the definition of metabolic health matter?
Metabolically healthy obesity and risk of mortality: Does the definition of metabolic health matter?
Millar S, Perry IJ, Phillips CM (2013) Surrogate measures of adiposity and cardiometabolic risk–why the uncertainty?
Phillips CM, Perry IJ (2013) Does inflammation determine metabolic health status in obese and non-obese adults?

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