We are analyzing https://link.springer.com/article/10.1007/s11154-007-9033-5.

Title:
Growth factor signalling in endocrine and anti-growth factor resistant breast cancer | Reviews in Endocrine and Metabolic Disorders
Description:
Growth factors provide powerful mitogenic and survival signals to breast cancer cells and it is therefore not surprising that they are able to subvert inhibitory responses to anti-hormonal drugs. In this review we discuss several mechanisms by which this may be achieved and expand our observations to encompass recently emerging anti-growth factor treatments. The information presented is underpinned by inhibitor studies that show the targeting of such mechanisms in advance of anti-hormone or anti-growth factor resistance development is able to substantially delay this event, thus pointing the way forward to intelligent combination therapies relevant to the future management of breast cancer.
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Keywords {🔍}

cancer, google, scholar, breast, cas, pubmed, growth, factor, receptor, cells, res, nicholson, gee, resistance, cell, epidermal, human, biol, barrow, hutcheson, endocr, endocrine, signalling, estrogen, oestrogen, tamoxifen, article, treat, mcf, tamoxifenresistant, kinase, insulinlike, jones, robertson, relat, mol, hiscox, knowlden, expression, chem, activity, phosphorylation, mcclelland, gefitinib, ici, inhibition, protein, activation, jmw, signaling,

Topics {✒️}

pcip/actr/aib-1/rac-3/tram-1 nf-kappab/ikappab signaling system anti-growth factor treatments mitogen-activated protein kinase estrogen-receptor-positive breast cancer growth factor cross-talk multi-functional pro-survival molecule anti-growth factor therapies phosphatidylinositol 3-kinase/akt-mediated activation er/her2-positive breast cancer tamoxifen-resistant mcf-7 cells tamoxifen-resistant tumorigenic growth hormone-independent tumor growth month download article/chapter antiestrogen-resistant breast cancer long-term oestrogen deprivation anti-hormone induced genes tamoxifen-resistant breast cancer improves anti-hormone response dual eerbb1/erbb2 inhibitor growth factors signal c-src-mediated phosphorylation endocrine-resistant breast cancer anti-hormonal therapy growth factor signalling estrogen-dependent gene expression endocrine therapy—current benefits enhanced anti-proliferative activity oestrogen receptor-mediated modulation ligand-bound oestrogen receptor anti-hormonal drugs growth factor receptor growth factor-1 receptor mcf-7 cells transfected growth factor signaling bidirectional cross talk tyrosine kinase inhibitors human cancer cells oestrogen-receptor positive human breast cancer c-met receptor phosphoinositide 3-kinase signalling long-term culture fibroblast growth factor mapk induces loss mcf-7 cells overexpressing steroid hormone receptors breast cancer growth nuclear factor-kappab mammary tumor cells

Questions {❓}

Selection of primary breast cancer patients for adjuvant endocrine therapy—is oestrogen receptor alone adequate?

Schema {🗺️}

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      headline:Growth factor signalling in endocrine and anti-growth factor resistant breast cancer
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