We are analyzing https://link.springer.com/article/10.1007/s11130-022-00996-x.

Title:
Quercetin, Engelitin and Caffeic Acid of Smilax china L. Polyphenols, Stimulate 3T3-L1 Adipocytes to Brown-like Adipocytes Via β3-AR/AMPK Signaling Pathway | Plant Foods for Human Nutrition
Description:
The aim of the present study was to investigate the browning effects mechanism of Smilax china L. polyphenols (SCLP) and its monomer. In this study, polyphenols (SCLP, engeletin, quercetin and caffeic acid) markedly suppressed lipid accumulation. Polyphenols significantly up-graded the expression of protein kinase A (PKA), adipose triglyceride lipase (ATGL), peroxisome proliferators-activated receptors alpha (PPARα), carnitine palmitoyl transferase (CPT) and acyl-CoA oxidase (ACO) to promote lipolysis and β-oxidation. Moreover, polyphenols greatly enhanced mitochondrial biogenesis in adipocytes, as demonstrated by the expression of Nrf1 and Tfam were up-regulated. Furthermore, polyphenols treatment greatly up-regulated the browning program in adipocytes by increased brown-specific genes and proteins uncoupling protein 1 (UCP-1), peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) and PR domain containing 16 (PRDM16), as well as beige-specific genes (Tmem26, Tbx1, CD137, Cited1), especially engeletin. Further research found that the brown-specific markers were decreased by antagonist treatment of AMPK or β3-AR, but polyphenols treatment reversed the effect of antagonists and improved the expression of UCP-1, PRDM16 and PGC-1α. In conclusion, these results indicated that polyphenols stimulate browning in adipocytes via activation of the β3-AR/AMPK signaling pathway, and SCLP and its monomer may be worth investigating to prevent obesity.
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Keywords {🔍}

article, pubmed, google, scholar, cas, adipocytes, polyphenols, browning, china, adipose, obesity, smilax, signaling, pathway, brown, liu, zheng, protein, tissue, central, data, receptor, activation, fat, nutr, cell, food, zhang, peroxisome, ucp, white, privacy, cookies, content, information, research, foods, guodong, expression, alpha, mitochondrial, proliferatoractivated, effect, supplementary, wang, author, springer, publish, search, plant,

Topics {✒️}

β3-ar/ampk signaling pathway rhodopsin-dependent β3-adrenergic signaling adiponectin-receptor/ampk signalling pathway high-energy-diet-fed rats ampk/α-ketoglutarate/prdm16 axis month download article/chapter ampk-pgc1α signaling pathway ampk signaling pathway writing–original draft preparation drp1-sparked mitochondrial apoptosis ameliorates diet-induced obesity ampk-dependent pathway activating ampk pathways mature 3t3-l1 adipocytes stimulate 3t3-l1 adipocytes 3t3-l1 white adipocytes β3-ar mitochondrial transcription factor pka/ampk signaling increased brown-specific genes article plant foods enhancing mitochondrial biogenesis human energy metabolism energy metabolism remodeling flavonoid-rich smilax china full article pdf guodong zheng zeaxanthin promotes browning beige fat development 3t3-l1 adipocytes 3t3-l1 cells zhen zhong privacy choices/manage cookies capsiate induces browning polyphenols stimulate browning electronic supplementary material human nutrition aims target genes related 3-isobutyl-1-methylxanthine nrf1 article kong browning effects mechanism white adipose tissue fat browning brown adipose tissue published article lipid metabolism polyphenols treatment greatly brown-specific markers treat metabolic disorders beige-specific genes

Questions {❓}

Evenocheck A, Rhee Y, Hall C (2020) Do health promoting compounds of flaxseed attenuate weight gain via modulation of obesity gene expression?
López M, Tena-Sempere M (2017) Estradiol effects on hypothalamic AMPK and BAT thermogenesis: a gateway for obesity treatment?

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         description:The aim of the present study was to investigate the browning effects mechanism of Smilax china L. polyphenols (SCLP) and its monomer. In this study, polyphenols (SCLP, engeletin, quercetin and caffeic acid) markedly suppressed lipid accumulation. Polyphenols significantly up-graded the expression of protein kinase A (PKA), adipose triglyceride lipase (ATGL), peroxisome proliferators-activated receptors alpha (PPARα), carnitine palmitoyl transferase (CPT) and acyl-CoA oxidase (ACO) to promote lipolysis and β-oxidation. Moreover, polyphenols greatly enhanced mitochondrial biogenesis in adipocytes, as demonstrated by the expression of Nrf1 and Tfam were up-regulated. Furthermore, polyphenols treatment greatly up-regulated the browning program in adipocytes by increased brown-specific genes and proteins uncoupling protein 1 (UCP-1), peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) and PR domain containing 16 (PRDM16), as well as beige-specific genes (Tmem26, Tbx1, CD137, Cited1), especially engeletin. Further research found that the brown-specific markers were decreased by antagonist treatment of AMPK or β3-AR, but polyphenols treatment reversed the effect of antagonists and improved the expression of UCP-1, PRDM16 and PGC-1α. In conclusion, these results indicated that polyphenols stimulate browning in adipocytes via activation of the β3-AR/AMPK signaling pathway, and SCLP and its monomer may be worth investigating to prevent obesity.
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      description:The aim of the present study was to investigate the browning effects mechanism of Smilax china L. polyphenols (SCLP) and its monomer. In this study, polyphenols (SCLP, engeletin, quercetin and caffeic acid) markedly suppressed lipid accumulation. Polyphenols significantly up-graded the expression of protein kinase A (PKA), adipose triglyceride lipase (ATGL), peroxisome proliferators-activated receptors alpha (PPARα), carnitine palmitoyl transferase (CPT) and acyl-CoA oxidase (ACO) to promote lipolysis and β-oxidation. Moreover, polyphenols greatly enhanced mitochondrial biogenesis in adipocytes, as demonstrated by the expression of Nrf1 and Tfam were up-regulated. Furthermore, polyphenols treatment greatly up-regulated the browning program in adipocytes by increased brown-specific genes and proteins uncoupling protein 1 (UCP-1), peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) and PR domain containing 16 (PRDM16), as well as beige-specific genes (Tmem26, Tbx1, CD137, Cited1), especially engeletin. Further research found that the brown-specific markers were decreased by antagonist treatment of AMPK or β3-AR, but polyphenols treatment reversed the effect of antagonists and improved the expression of UCP-1, PRDM16 and PGC-1α. In conclusion, these results indicated that polyphenols stimulate browning in adipocytes via activation of the β3-AR/AMPK signaling pathway, and SCLP and its monomer may be worth investigating to prevent obesity.
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