We are analyzing https://link.springer.com/article/10.1007/s11095-011-0604-5.

Title:
RNA Interference and Cancer Therapy | Pharmaceutical Research
Description:
Since its discovery in 1998, RNA interference (RNAi) has revolutionized basic and clinical research. Small RNAs, including small interfering RNA (siRNA), short hairpin RNA (shRNA) and microRNA (miRNA), mediate RNAi effects through either cleavage-dependent or cleavage-independent RNA inducible silencing complex (RISC) effector processes. As a result of its efficacy and potential, RNAi has been elevated to the status of “blockbuster therapeutic” alongside recombinant protein and monoclonal antibody. RNAi has already contributed to our understanding of neoplasia and has great promise for anti-cancer therapeutics, particularly so for personalized cancer therapy. Despite this potential, several hurdles have to be overcome for successful development of RNAi-based pharmaceuticals. This review will discuss the potential for, challenges to, and the current status of RNAi-based cancer therapeutics.
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Keywords {🔍}

pubmed, article, google, scholar, cas, cancer, central, rna, microrna, nat, gene, sirna, interference, nature, cells, rnai, silencing, delivery, expression, cell, res, therapy, wang, nemunaitis, usa, senzer, john, therapeutic, human, clin, small, vivo, biotechnol, ther, liu, research, rnas, interfering, mammalian, biol, texas, function, mol, lee, targeted, sci, micrornas, zhang, chen, tumor,

Topics {✒️}

month download article/chapter antigen-specific anti-tumor immunity hypoxia-inducible factor-1α stem-loop rt-pcr pin1-targeted rna interference rnai-based cancer therapeutics mir-10b inhibits metastasis p-body component gw182 messenger ribonucleic acid target-independent angiogenesis suppression u6 promoter-driven sirnas microrna-92a controls angiogenesis rgd-labeled chitosan nanoparticles uncovering growth-suppressive micrornas personalized cancer therapy rnai-mediated gene silencing multiple cell-cycle genes anti-cancer therapeutics full article pdf cancer sirna therapy sirna-mediated gene silencing sequence-specific potent induction short interfering rna synthetic microrna-16 inhibits interference rna intervention short hairpin rna john nemunaitis gene-specific interference tumor selective delivery small-molecule inhibitors metastatic prostate tumors cancer therapy privacy choices/manage cookies nucleic acids res short-interfering rnas short interfering rnas specific genetic interference cancer gene ther double-stranded rna related subjects rnai-mediated silencing cell-mediated suppression human furin convertase inducing cellular senescence antigen presentation attenuator rna-based oligonucleotides targeted gene silencing safe rnai therapeutic trends biochem sci cancer therapeutics

Schema {🗺️}

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      headline:RNA Interference and Cancer Therapy
      description:Since its discovery in 1998, RNA interference (RNAi) has revolutionized basic and clinical research. Small RNAs, including small interfering RNA (siRNA), short hairpin RNA (shRNA) and microRNA (miRNA), mediate RNAi effects through either cleavage-dependent or cleavage-independent RNA inducible silencing complex (RISC) effector processes. As a result of its efficacy and potential, RNAi has been elevated to the status of “blockbuster therapeutic” alongside recombinant protein and monoclonal antibody. RNAi has already contributed to our understanding of neoplasia and has great promise for anti-cancer therapeutics, particularly so for personalized cancer therapy. Despite this potential, several hurdles have to be overcome for successful development of RNAi-based pharmaceuticals. This review will discuss the potential for, challenges to, and the current status of RNAi-based cancer therapeutics.
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