We are analyzing https://link.springer.com/article/10.1007/s11095-005-8343-0.

Title:
Poly(Ethylene Oxide)-Modified Poly(β-Amino Ester) Nanoparticles as a pH-Sensitive System for Tumor-Targeted Delivery of Hydrophobic Drugs: Part 2. In Vivo Distribution and Tumor Localization Studies | Pharmaceutical Research
Description:
Purpose This study was carried out to determine the biodistribution profiles and tumor localization potential of poly(ethylene oxide) (PEO)-modified poly(β-amino ester) (PbAE) as a novel, pH-sensitive biodegradable polymeric nanoparticulate system for tumor-targeted drug delivery. Methods The biodistribution studies of PEO-modified PbAE and PEO-modified poly(ɛ-caprolactone) (PCL), a non-pH-sensitive polymer, nanoparticle systems were carried out in normal mice using 111indium-oxine [111In] as a lipophilic radiolabel encapsulated within the polymeric matrix, and the distribution of the nanoparticles was studied in plasma and all the vital organs following intravenous administration. Solid tumors were developed on nude mice using human ovarian carcinoma xenograft (SKOV-3) and the change in concentrations of tritium [3H]-labeled paclitaxel encapsulated in polymeric nanoparticles was examined in blood, tumor mass, and liver. Results Study in normal mice with a gamma-emitting isotope [111In] provided a thorough biodistribution analysis of the PEO-modified nanoparticulate carrier systems, whereas 3H-paclitaxel was useful to understand the change in concentration and tumor localization of anticancer compound directly in major sites of distribution. Both PEO-PbAE and PEO-PCL nanoparticles showed long systemic circulating properties by virtue of surface modification with PEO-containing triblock block copolymer (Pluronic®) stabilizer. Although the PCL nanoparticles showed higher uptake by the reticuloendothelial system, the PbAE nanoparticles effectively delivered the encapsulated payload into the tumor mass. Conclusions PEO-modified PbAE nanoparticles showed considerable passive tumor targeting potential in early stages of biodistribution via the enhanced permeation and retention (EPR) mechanism. This prompts a detailed biodistribution profiling of the nanocarrier for prolonged periods to provide conclusive evidence for superiority of the delivery system.
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Topics {✒️}

dc%2bd2czmsvoiug%3d%3d 10 polymer/lipid core-shell nanoconstructs month download article/chapter ph-sensitive biodegradable system cyclosporine-loaded polycaprolactone nanoparticles dc%2bd3mxlsvkislo%3d 10 dc%2bd3mxkslyjs7g%3d 10 dc%2bd2cxjtlymtl0%3d 10 dc%2bd3cxjslyisrg%3d 10 dc%2bd3cxjslyisrs%3d 10 dc%2bd3mxntvwku78%3d 10 dc%2bd3cxit1knsb4%3d 10 dyal3cxpvfghta%3d%3d 10 ph-responsive polymer microspheres peo/ppo block copolymers tumor targeting access biomedical applications adv tumor-targeted drug delivery tumor localization potential full article pdf ph-sensitive polymer related subjects nanoparticle-mediated gene delivery ph-sensitive system related biodegradable polyesters peo-modified pbae noncompartmental pharmacokinetic analysis zeta potential measurements tumor localization studies poly-beta amino ester pharmaceutical applications adv privacy choices/manage cookies biodegradable polymeric nanoparticles long-circulating poly tumor-targeted delivery 111indium-oxine [111in] intracellular ph angew professor robert campbell biodegradable materials breast cancer int drug carrier syst modified gelatin nanoparticles degradable polymer library peo-modified poly dendrimer delivery systems solid lipid nanoparticles tissue adv polymeric gene delivery triblock block copolymer beta-amino ester

Questions {❓}

Kissel (2000) Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake?

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