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We are analyzing https://link.springer.com/article/10.1007/s11060-013-1207-2.

Title:
Prognostic significance of CD147 in patients with glioblastoma | Journal of Neuro-Oncology
Description:
CD147, also known as extracellular matrix metalloproteinase inducer, is a widely distributed cell surface glycoprotein that belongs to the immunoglobulin superfamily. CD147 has been proved to be enriched on the surface of many tumor cells, promoting tumor growth, invasion and metastasis by its stimulation effect on adjacent fibroblasts to produce matrix metalloproteinases. In this study, we aimed to explore the expression pattern of CD147 in glioblastoma (GBM) and investigate whether it could be used to assess subsequent prognosis of patients. For that, we recruited a total of 206 patients with pathologically confirmed GBM and 36 normal control brain tissue specimens. The expression of CD147 in GBM and normal tissues was investigated by immunohistochemistry assay. Genetic factors including MGMT and IDH1 mutation were also investigated to justify the prognostic significance of CD147. Results showed that CD147 expression was increased in GBM compared with that in normal tissues. Kaplan–Meier analysis showed that increased CD147 expression was associated with poor overall survival of patients with GBM. Moreover, Cox’s proportional hazards model revealed that CD147 expression was an independent and significant prognostic marker of overall survival in GBM patients. These results proved that CD147 expression was relatively abundant in GBM and can be potentially used to predict prognosis and treatment response in GBM patients.
Website Age:
28 years and 1 months (reg. 1997-05-29).

Matching Content Categories {šŸ“š}

  • Education
  • Science
  • Health & Fitness

Content Management System {šŸ“}

What CMS is link.springer.com built with?

Custom-built

No common CMS systems were detected on Link.springer.com, and no known web development framework was identified.

Traffic Estimate {šŸ“ˆ}

What is the average monthly size of link.springer.com audience?

🌠 Phenomenal Traffic: 5M - 10M visitors per month


Based on our best estimate, this website will receive around 5,000,019 visitors per month in the current month.
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How Does Link.springer.com Make Money? {šŸ’ø}

We're unsure how the site profits.

While profit motivates many websites, others exist to inspire, entertain, or provide valuable resources. Websites have a variety of goals. And this might be one of them. Link.springer.com might be making money, but it's not detectable how they're doing it.

Keywords {šŸ”}

article, google, scholar, pubmed, cas, zhang, expression, cancer, wang, glioblastoma, patients, chen, yang, mmp, oncol, matrix, cell, prognosis, gbm, prognostic, zhao, liang, metalloproteinase, survival, human, yuan, study, poor, glioma, clin, res, neurooncol, dois, china, privacy, cookies, content, journal, yan, extracellular, inducer, tumor, cells, normal, marker, access, malignant, multiforme, han, liu,

Topics {āœ’ļø}

month download article/chapter high-grade malignant glioma extracellular membrane-proximal domain il-6/stat3 survival signaling normal human brain cd147-targeting sirna inhibits kaplan–meier analysis showed related subjects promoting tumor growth full article pdf cell surface inducer glioblastoma cell line matrix metalloproteinase induction matrix metalloproteinase modulator author information authors privacy choices/manage cookies newly diagnosed glioblastoma molecular markers assess subsequent prognosis epithelio-stromal interactions human glioblastoma multiforme modulate malignant properties significant prognostic marker dietrich py epithelial ovarian cancer primary glioblastoma recurrence prostate cancer progression poor prognostic marker produce matrix metalloproteinases immunohistochemistry assay salivary duct carcinoma integrated genomic analysis independent prognostic marker european economic area beta-strand swapping monoclonal antibody 12c3 bi xc short-term survivors neuro-oncology aims conditions privacy policy article yang 1007/s11060-013-1102 check access instant access zhong wd diaz la jr liang wang article journal hab18g/cd147 binds glutamine synthetase expression

Schema {šŸ—ŗļø}

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         headline:Prognostic significance of CD147 in patients with glioblastoma
         description:CD147, also known as extracellular matrix metalloproteinase inducer, is a widely distributed cell surface glycoprotein that belongs to the immunoglobulin superfamily. CD147 has been proved to be enriched on the surface of many tumor cells, promoting tumor growth, invasion and metastasis by its stimulation effect on adjacent fibroblasts to produce matrix metalloproteinases. In this study, we aimed to explore the expression pattern of CD147 in glioblastoma (GBM) and investigate whether it could be used to assess subsequent prognosis of patients. For that, we recruited a total of 206 patients with pathologically confirmed GBM and 36 normal control brain tissue specimens. The expression of CD147 in GBM and normal tissues was investigated by immunohistochemistry assay. Genetic factors including MGMT and IDH1 mutation were also investigated to justify the prognostic significance of CD147. Results showed that CD147 expression was increased in GBM compared with that in normal tissues. Kaplan–Meier analysis showed that increased CD147 expression was associated with poor overall survival of patients with GBM. Moreover, Cox’s proportional hazards model revealed that CD147 expression was an independent and significant prognostic marker of overall survival in GBM patients. These results proved that CD147 expression was relatively abundant in GBM and can be potentially used to predict prognosis and treatment response in GBM patients.
         datePublished:2013-08-08T00:00:00Z
         dateModified:2013-08-08T00:00:00Z
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            CD147
            Glioblastoma
            Immunohistochemistry
            Prognosis
            Oncology
            Neurology
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                        name:Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
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      headline:Prognostic significance of CD147 in patients with glioblastoma
      description:CD147, also known as extracellular matrix metalloproteinase inducer, is a widely distributed cell surface glycoprotein that belongs to the immunoglobulin superfamily. CD147 has been proved to be enriched on the surface of many tumor cells, promoting tumor growth, invasion and metastasis by its stimulation effect on adjacent fibroblasts to produce matrix metalloproteinases. In this study, we aimed to explore the expression pattern of CD147 in glioblastoma (GBM) and investigate whether it could be used to assess subsequent prognosis of patients. For that, we recruited a total of 206 patients with pathologically confirmed GBM and 36 normal control brain tissue specimens. The expression of CD147 in GBM and normal tissues was investigated by immunohistochemistry assay. Genetic factors including MGMT and IDH1 mutation were also investigated to justify the prognostic significance of CD147. Results showed that CD147 expression was increased in GBM compared with that in normal tissues. Kaplan–Meier analysis showed that increased CD147 expression was associated with poor overall survival of patients with GBM. Moreover, Cox’s proportional hazards model revealed that CD147 expression was an independent and significant prognostic marker of overall survival in GBM patients. These results proved that CD147 expression was relatively abundant in GBM and can be potentially used to predict prognosis and treatment response in GBM patients.
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         Glioblastoma
         Immunohistochemistry
         Prognosis
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         Neurology
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            name:Yang Yuan
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                  address:
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                     type:PostalAddress
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                  address:
                     name:Department of Neurosurgery, 107 Hospital of PLA, Yantai, People’s Republic of China
                     type:PostalAddress
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            type:Person
            name:Hua Zhang
            affiliation:
                  name:The Fourth Military Medical University
                  address:
                     name:Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Ming Yan
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                  name:The Fourth Military Medical University
                  address:
                     name:Institute of Orthopaedics and Traumatology of PLA of China, Xijing Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
                     type:PostalAddress
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            name:Shumei Wang
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                  address:
                     name:Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
                     type:PostalAddress
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            affiliation:
                  name:The Fourth Military Medical University
                  address:
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                     type:PostalAddress
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                  name:The Fourth Military Medical University
                  address:
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                     type:PostalAddress
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                     type:PostalAddress
                  type:Organization
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            name:Baofu Li
            affiliation:
                  name:The Fourth Military Medical University
                  address:
                     name:Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Guodong Gao
            affiliation:
                  name:The Fourth Military Medical University
                  address:
                     name:Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
                     type:PostalAddress
                  type:Organization
            type:Person
            name:Jipei Zhao
            affiliation:
                  name:The Fourth Military Medical University
                  address:
                     name:Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
                     type:PostalAddress
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         name:Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
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      name:The Fourth Military Medical University
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      name:Min Yang
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            name:The Fourth Military Medical University
            address:
               name:Institute of Orthopaedics and Traumatology of PLA of China, Xijing Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Yang Yuan
      affiliation:
            name:The Fourth Military Medical University
            address:
               name:Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
               type:PostalAddress
            type:Organization
            name:107 Hospital of PLA
            address:
               name:Department of Neurosurgery, 107 Hospital of PLA, Yantai, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Hua Zhang
      affiliation:
            name:The Fourth Military Medical University
            address:
               name:Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Ming Yan
      affiliation:
            name:The Fourth Military Medical University
            address:
               name:Institute of Orthopaedics and Traumatology of PLA of China, Xijing Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Shumei Wang
      affiliation:
            name:The Fourth Military Medical University
            address:
               name:Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Fuqiang Feng
      affiliation:
            name:The Fourth Military Medical University
            address:
               name:Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Peigang Ji
      affiliation:
            name:The Fourth Military Medical University
            address:
               name:Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Yi Li
      affiliation:
            name:The Fourth Military Medical University
            address:
               name:Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Baofu Li
      affiliation:
            name:The Fourth Military Medical University
            address:
               name:Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Guodong Gao
      affiliation:
            name:The Fourth Military Medical University
            address:
               name:Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
               type:PostalAddress
            type:Organization
      name:Jipei Zhao
      affiliation:
            name:The Fourth Military Medical University
            address:
               name:Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
               type:PostalAddress
            type:Organization
      email:[email protected]
      name:Liang Wang
      affiliation:
            name:The Fourth Military Medical University
            address:
               name:Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
               type:PostalAddress
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      name:Institute of Orthopaedics and Traumatology of PLA of China, Xijing Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
      name:Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
      name:Department of Neurosurgery, 107 Hospital of PLA, Yantai, People’s Republic of China
      name:Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
      name:Institute of Orthopaedics and Traumatology of PLA of China, Xijing Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
      name:Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
      name:Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
      name:Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
      name:Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
      name:Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
      name:Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
      name:Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
      name:Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China
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External Links {šŸ”—}(179)

Analytics and Tracking {šŸ“Š}

  • Google Tag Manager

Libraries {šŸ“š}

  • Clipboard.js
  • Prism.js

CDN Services {šŸ“¦}

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