We are analyzing https://link.springer.com/article/10.1007/s11046-011-9464-0.

Title:
‘Popping the Clutch’: Novel Mechanisms Regulating Sexual Development in Cryptococcus neoformans | Mycopathologia
Description:
Sexual reproduction in fungal pathogens such as Cryptococcus provides natural selection and adaptation of the organisms to environmental conditions by allowing beneficial mutations to spread. However, successful mating in these fungi requires a time-critical induction of signaling pheromones when appropriate partners become available. Recently, it has been shown that the fungus uses the transcriptional equivalent of the racing technique: ‘popping the clutch’—pushing in the clutch pedal, putting the car in gear, revving with the gas pedal, and then dropping the clutch pedal to accelerate rapidly. In the same way, Cryptococcus during vegetative growth constitutively matches a high rate of pheromone synthesis with a high rate of degradation to produce repressed levels of transcript. Then, when mating is required, the fungus drops the degradative machinery, resulting in a rapid induction of the pheromone. Pairing with this novel regulatory cycle is a host of mitogen-activated protein kinase cascades, cyclic AMP-dependent, and calcium-calcineurin signaling pathways that maintain these high rates of pheromone synthesis and prime downstream pathways for an effective mating response. The intersection of a number of virulence-associated traits with sexual development such as the synthesis of an immune-disruptive laccase as well as a protective polysaccharide capsule makes these rapid regulatory strategies a formidable foe in the battle against human disease.
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Keywords {🔍}

google, scholar, article, pubmed, cas, cryptococcus, neoformans, cell, biol, fungal, mating, mol, protein, yeast, heitman, sexual, signaling, kinase, pheromone, eukaryot, microbiol, virulence, human, pathogen, calcineurin, analysis, development, williamson, access, genet, nature, cerevisiae, pathway, privacy, cookies, content, response, pathogenic, kwonchung, regulates, publish, research, search, clutch, park, required, regulatory, mitogenactivated, cyclic, filobasidiella,

Topics {✒️}

ca2+-calmodulin-dependent protein kinase month download article/chapter kj kwon-chung cyclic amp-protein kinase ca2+-calmodulin promotes survival calcineurin-responsive transcription factor loop–loop recognition motif regulates fungal growth transcriptional/degradative “futile cycle” pheromone-induced growth arrest related subjects chromosomal sex-determining regions calcineurin-dependent hyphal elongation calcium-calcineurin signaling pathways invasive fungal infections cyclic amp-dependent fungal genet biol article mycopathologia aims cyclic amp signaling full article pdf cell type specific {alpha} protein gpa1 intramural research program privacy choices/manage cookies [alpha]-factor arrest fraser ja helpful manuscript review mating-type locus transcription factors mat2 calcium signaling components annu rev biochem nat rev microbiol article park lengeler kb fus3 represses cln1 protein cap forms commun integr biol calcineurin mediates inhibition fungal pathogens prime downstream pathways fungal kingdoms fems yeast res ras-dependent activation check access instant access cryptococcus neoformans mating effective mating response european economic area allowing beneficial mutations produce repressed levels

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         headline:‘Popping the Clutch’: Novel Mechanisms Regulating Sexual Development in Cryptococcus neoformans
         description:Sexual reproduction in fungal pathogens such as Cryptococcus provides natural selection and adaptation of the organisms to environmental conditions by allowing beneficial mutations to spread. However, successful mating in these fungi requires a time-critical induction of signaling pheromones when appropriate partners become available. Recently, it has been shown that the fungus uses the transcriptional equivalent of the racing technique: ‘popping the clutch’—pushing in the clutch pedal, putting the car in gear, revving with the gas pedal, and then dropping the clutch pedal to accelerate rapidly. In the same way, Cryptococcus during vegetative growth constitutively matches a high rate of pheromone synthesis with a high rate of degradation to produce repressed levels of transcript. Then, when mating is required, the fungus drops the degradative machinery, resulting in a rapid induction of the pheromone. Pairing with this novel regulatory cycle is a host of mitogen-activated protein kinase cascades, cyclic AMP-dependent, and calcium-calcineurin signaling pathways that maintain these high rates of pheromone synthesis and prime downstream pathways for an effective mating response. The intersection of a number of virulence-associated traits with sexual development such as the synthesis of an immune-disruptive laccase as well as a protective polysaccharide capsule makes these rapid regulatory strategies a formidable foe in the battle against human disease.
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            Plant Sciences
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      headline:‘Popping the Clutch’: Novel Mechanisms Regulating Sexual Development in Cryptococcus neoformans
      description:Sexual reproduction in fungal pathogens such as Cryptococcus provides natural selection and adaptation of the organisms to environmental conditions by allowing beneficial mutations to spread. However, successful mating in these fungi requires a time-critical induction of signaling pheromones when appropriate partners become available. Recently, it has been shown that the fungus uses the transcriptional equivalent of the racing technique: ‘popping the clutch’—pushing in the clutch pedal, putting the car in gear, revving with the gas pedal, and then dropping the clutch pedal to accelerate rapidly. In the same way, Cryptococcus during vegetative growth constitutively matches a high rate of pheromone synthesis with a high rate of degradation to produce repressed levels of transcript. Then, when mating is required, the fungus drops the degradative machinery, resulting in a rapid induction of the pheromone. Pairing with this novel regulatory cycle is a host of mitogen-activated protein kinase cascades, cyclic AMP-dependent, and calcium-calcineurin signaling pathways that maintain these high rates of pheromone synthesis and prime downstream pathways for an effective mating response. The intersection of a number of virulence-associated traits with sexual development such as the synthesis of an immune-disruptive laccase as well as a protective polysaccharide capsule makes these rapid regulatory strategies a formidable foe in the battle against human disease.
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