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ANRIL, H19 and TUG1: a review about critical long non-coding RNAs in cardiovascular diseases | Molecular Biology Reports
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Cardiovascular diseases are the leading cause of death worldwide. They are non-transmissible diseases that affect the cardiovascular system and have different etiologies such as smoking, lipid disorders, diabetes, stress, sedentary lifestyle and genetic factors. To date, lncRNAs have been associated with increased susceptibility to the development of cardiovascular diseases such as hypertension, acute myocardial infarction, stroke, angina and heart failure. In this way, lncRNAs are becoming a very promising point for the prevention and diagnosis of cardiovascular diseases. Therefore, this review highlights the most important and recent discoveries about the mechanisms of action of the lncRNAs ANRIL, H19 and TUG1 and their clinical relevance in these pathologies. This may contribute to early detection of cardiovascular diseases in order to prevent the pathological phenotype from becoming established.
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met/h19/mir-216-3p/ebi3 signaling pathways pi3k/akt/gsk-3β signalling pathway met/h19/mir-148a-5p/p28 targeting mir-19a/socs1/p53 axis negatively regulating micror-29b-3p month download article/chapter renal fibrosis—turning challenges pi3k/akt/mtor pathways mir-423-5p/nox4 axis mir-29b/c1qtnf6 axis mir-1-3p/adam10 axis microrna-145-3p/smad4 axis microrna-374c-mediated foxc1 negatively regulating mir-34a pbx3/cyp1b1-dependent manner targeting muscle-enriched long inhibiting mtorc1/eif4ebp1 pathway coding rna cdkn2b-as1 instituto butantan escola de farmácia da silva lncrna h19 promotes hyperglycemic-induced inflammation full article pdf nf-κb pathway pulmonary arterial hypertension hypoxic pulmonary hypertension pulmonary artery cells sequestering mir-129-5p vascular endothelial cells systemic lupus erythematosus pulmonary vascular remodeling maladaptive cardiac remodelling coding rna h19 coding rna-h19 acute myocardial infarction mir-152/vegfa axis h19 gene imprinting privacy choices/manage cookies hypertension genetics past laboratório de dor coding rna anril downregulating lncrna tug1 lncrna tug1 involves dysregulated lncrna tug1 chronic kidney disease myocardial ischemic preconditioning endothelial cell messengers coronary artery disease human pancreatic islets
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headline:ANRIL, H19 and TUG1: a review about critical long non-coding RNAs in cardiovascular diseases
description:Cardiovascular diseases are the leading cause of death worldwide. They are non-transmissible diseases that affect the cardiovascular system and have different etiologies such as smoking, lipid disorders, diabetes, stress, sedentary lifestyle and genetic factors. To date, lncRNAs have been associated with increased susceptibility to the development of cardiovascular diseases such as hypertension, acute myocardial infarction, stroke, angina and heart failure. In this way, lncRNAs are becoming a very promising point for the prevention and diagnosis of cardiovascular diseases. Therefore, this review highlights the most important and recent discoveries about the mechanisms of action of the lncRNAs ANRIL, H19 and TUG1 and their clinical relevance in these pathologies. This may contribute to early detection of cardiovascular diseases in order to prevent the pathological phenotype from becoming established.
datePublished:2023-12-28T00:00:00Z
dateModified:2023-12-28T00:00:00Z
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Genetic factors
Non-coding RNA
lncRNA ANRIL
lncRNA H19
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Animal Biochemistry
Animal Anatomy / Morphology / Histology
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headline:ANRIL, H19 and TUG1: a review about critical long non-coding RNAs in cardiovascular diseases
description:Cardiovascular diseases are the leading cause of death worldwide. They are non-transmissible diseases that affect the cardiovascular system and have different etiologies such as smoking, lipid disorders, diabetes, stress, sedentary lifestyle and genetic factors. To date, lncRNAs have been associated with increased susceptibility to the development of cardiovascular diseases such as hypertension, acute myocardial infarction, stroke, angina and heart failure. In this way, lncRNAs are becoming a very promising point for the prevention and diagnosis of cardiovascular diseases. Therefore, this review highlights the most important and recent discoveries about the mechanisms of action of the lncRNAs ANRIL, H19 and TUG1 and their clinical relevance in these pathologies. This may contribute to early detection of cardiovascular diseases in order to prevent the pathological phenotype from becoming established.
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