We are analyzing https://link.springer.com/article/10.1007/s11033-019-05057-2.

Title:
Expression of selected miRNA, RARβ and FHIT genes in BALf of squamous cell lung cancer (squamous-cell carcinoma, SCC) patients: a pilot study | Molecular Biology Reports
Description:
Two suppressor genes which often undergo epigenetic silencing during the early stages of lung carcinogenesis are those encoding retinoic acid receptor-β (RARβ) and Fhit protein (FHIT). RARβ expression is regulated by miRNA-34a and miRNA-141, and FHIT expression by miRNA-143 and miRNA-217. The aim of the study was to assess how selected miRNAs regulate the expression of their targeted genes in bronchoalveolar lavage fluid (BALf), obtained from patients with SCC of the lung. It also examines the relationship between the genetic findings and the clinical and pathomorphological features of the tumor. A total of 50 BALf samples were taken: 25 from patients with SCC and 25 from healthy donors. The expression (RQ) of the selected genes was analyzed by qPCR, as well as the miRNA level, with a particular emphasis on the relationship between the expression of the genes themselves and their corresponding miRNAs; in addition, the expression of the genes and miRNAs were compared with the pathomorphological features of the tumor and the clinical features of patients. Analysis of the RQ values showed downregulation of RARß, FHIT and miRNA-34a and increased expression of miRNA-141, miRNA-143 and miRNA-217 in all BALf samples (P > 0.05). No correlation was found between the expression of the selected genes and corresponding miRNAs, history of smoking, cancer stage, age and sex of the patients. The presence of the selected genes and miRNAs in BALf material does not seem to have diagnostic potential in patients with SCC; however, the results should be verified on a larger group of patients.
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Keywords {🔍}

lung, expression, cancer, mirna, fhit, patients, article, scc, study, balf, mirnas, google, scholar, genes, cell, cas, gene, rarβ, tumor, diagnostic, studies, nsclc, analysis, molecular, material, present, clinical, found, group, table, selected, samples, development, microrna, test, protein, results, role, lodz, rna, data, squamous, fluid, genetic, level, values, rarß, loss, poland, patient,

Topics {✒️}

paired macroscopically-unchanged tissues real-time pcr small-cell lung cancer small-cell lung carcinoma mann–whitney u-test u-mann–whitney test catalogue numbers fhit—hs00179987_m1 article download pdf squamous-cell carcinoma squamous cell carcinoma statistically significant relationships national research committee privacy choices/manage cookies domańska-senderowska full access binds retinoic acid gene promoter methylation tissue cell type lung cancer diagnosis protein products play including lung cancer lung cancer—quantification low cell amount retinoic acid receptors gene expression requires tumour suppressor gene shapiro–wilk test kruskal–wallis test prostate cancer risk routine diagnostic due primary lung tumors written informed consent main content log 5-year survival rate term “genetic landscape fragile histidine triad biologically- active form chest x-ray β-actvb adjusted procedure frequently appeared individualized therapeutic tools ethics declarations conflict individual participants included advanced lung cancer cell lines scc histologic subtype bronchoalveolar lavage fluid multiple group comparisons tumor suppressor gene preneoplastic bronchial lesions

Schema {🗺️}

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         headline:Expression of selected miRNA, RARβ and FHIT genes in BALf of squamous cell lung cancer (squamous-cell carcinoma, SCC) patients: a pilot study
         description:Two suppressor genes which often undergo epigenetic silencing during the early stages of lung carcinogenesis are those encoding retinoic acid receptor-β (RARβ) and Fhit protein (FHIT). RARβ expression is regulated by miRNA-34a and miRNA-141, and FHIT expression by miRNA-143 and miRNA-217. The aim of the study was to assess how selected miRNAs regulate the expression of their targeted genes in bronchoalveolar lavage fluid (BALf), obtained from patients with SCC of the lung. It also examines the relationship between the genetic findings and the clinical and pathomorphological features of the tumor. A total of 50 BALf samples were taken: 25 from patients with SCC and 25 from healthy donors. The expression (RQ) of the selected genes was analyzed by qPCR, as well as the miRNA level, with a particular emphasis on the relationship between the expression of the genes themselves and their corresponding miRNAs; in addition, the expression of the genes and miRNAs were compared with the pathomorphological features of the tumor and the clinical features of patients. Analysis of the RQ values showed downregulation of RARß, FHIT and miRNA-34a and increased expression of miRNA-141, miRNA-143 and miRNA-217 in all BALf samples (P > 0.05). No correlation was found between the expression of the selected genes and corresponding miRNAs, history of smoking, cancer stage, age and sex of the patients. The presence of the selected genes and miRNAs in BALf material does not seem to have diagnostic potential in patients with SCC; however, the results should be verified on a larger group of patients.
         datePublished:2019-09-09T00:00:00Z
         dateModified:2019-09-09T00:00:00Z
         pageStart:6593
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      headline:Expression of selected miRNA, RARβ and FHIT genes in BALf of squamous cell lung cancer (squamous-cell carcinoma, SCC) patients: a pilot study
      description:Two suppressor genes which often undergo epigenetic silencing during the early stages of lung carcinogenesis are those encoding retinoic acid receptor-β (RARβ) and Fhit protein (FHIT). RARβ expression is regulated by miRNA-34a and miRNA-141, and FHIT expression by miRNA-143 and miRNA-217. The aim of the study was to assess how selected miRNAs regulate the expression of their targeted genes in bronchoalveolar lavage fluid (BALf), obtained from patients with SCC of the lung. It also examines the relationship between the genetic findings and the clinical and pathomorphological features of the tumor. A total of 50 BALf samples were taken: 25 from patients with SCC and 25 from healthy donors. The expression (RQ) of the selected genes was analyzed by qPCR, as well as the miRNA level, with a particular emphasis on the relationship between the expression of the genes themselves and their corresponding miRNAs; in addition, the expression of the genes and miRNAs were compared with the pathomorphological features of the tumor and the clinical features of patients. Analysis of the RQ values showed downregulation of RARß, FHIT and miRNA-34a and increased expression of miRNA-141, miRNA-143 and miRNA-217 in all BALf samples (P > 0.05). No correlation was found between the expression of the selected genes and corresponding miRNAs, history of smoking, cancer stage, age and sex of the patients. The presence of the selected genes and miRNAs in BALf material does not seem to have diagnostic potential in patients with SCC; however, the results should be verified on a larger group of patients.
      datePublished:2019-09-09T00:00:00Z
      dateModified:2019-09-09T00:00:00Z
      pageStart:6593
      pageEnd:6597
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      sameAs:https://doi.org/10.1007/s11033-019-05057-2
      keywords:
         miRNA
         FHIT
         RARbeta
         Lung cancer
         Squamous cell lung cancer
         Animal Biochemistry
         Animal Anatomy / Morphology / Histology
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      name:Adam Antczak
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            name:Medical University of Lodz
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               type:PostalAddress
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      name:Daria Domańska-Senderowska
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            name:Medical University of Lodz
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      name:Department of General and Oncological Pulmonology, Medical University of Lodz, Lodz, Poland
      name:Department of Molecular Bases of Medicine, Medical University of Lodz, Lodz, Poland
      name:Department of Molecular Bases of Medicine, Medical University of Lodz, Lodz, Poland

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