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Title:
Ebselen, a promising antioxidant drug: mechanisms of action and targets of biological pathways | Molecular Biology Reports
Description:
Ebselen, an organoselenium compound, mimics glutathione peroxidase activity. It is a multifunctional compound, which catalyzes several essential reactions for the protection of cellular components from oxidative and free radical damage. Based on a number of in vitro and in vivo studies, various mechanisms are proposed to understand the biomedical actions of ebselen in health and diseases. It modulates metallo-proteins, enzymatic cofactors, gene expression, epigenetics, antioxidant defenses and immune systems. Owing to these properties, ebselen is currently under clinical trials for the prevention and treatment of various disorders such as cardiovascular diseases, arthritis, stroke, atherosclerosis, and cancer. A few ebselen-based pharmaceutical agents are under extensive investigation. As ebselen has been shown to have significant cellular toxicity, appropriate studies are needed to redesign the ebselen-based therapy for clinical trials. This review summarizes current understanding of the biochemical and molecular properties, and pharmacological applications of ebselen and future directions in this area of research.
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Keywords {🔍}

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Topics {✒️}

c-jun n-terminal kinase jun-n-terminal kinase hexokinase-selected small-molecule library tumor necrosis factor ask1-p38 mapk-p53 mec1/rad53 kinase cascade cytokine-activated vascular endothelium nf-kappab signaling pathway randomised open-label trial adriamycin-induced mouse cardiac inducing nrf-2-dependent transcription /gpx1-double knockout mouse initiator caspase-activating complex single-strand breaks caused hyperglycemia-mediated endothelial dysfunction fluconazole-resistant candida albicans mitochondrial anti-oxidant defence seleno-organic compound ebselen small-molecule screening identifies month download article/chapter nitrogen mustard-induced apoptosis hydrogen peroxide-induced cytotoxicity ebselen-based pharmaceutical agents zinc-finger transcription factors anti-inflammatory drug ebselen anti-oxidant ebselen antagonizes inhibits nitric oxide double-blind clinical trial multi-target-directed ligands sephadex-induced lung inflammation anti-inflammatory agent ebselen cardiac antioxidant defense—ebselen chronically iron-overloaded mice dmt1-mediated iron uptake preserves beta-cell mass stress protein expression ischemia-reperfusion injury apoptotic cell death radiation-induced apoptosis central nervous system inhibits melanin biosynthesis structure-activity relationship fas-mediated formation programmed neuronal death seleno-organic compounds apoptogenic factor cytochrome protein kinase cytoskeletal proteins induced seleno-organic antioxidant privacy choices/manage cookies

Questions {❓}

Afanas’ev I (2011) ROS and RNS signaling in heart disorders: could antioxidant treatment be successful?
Belmaker RH, Bersudsky Y, Agam G, Levine J, Kofman O (1996) How does lithium work on manic depression?
Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C?

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